Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Research of Service Administration Health and Sains Healthys
Rabsanjani, Rabsanjani
Unknown Affiliation
Health Professions Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
The Role of Microglia and Astrocytes in the Neuroinflammation Process in Acute Ischaemic Stroke Qomala, Dianing Aluh; Jayawardhana, I Ketut Wisnuaji; Abtartu, Lalu Hizrian; Rabsanjani, Rabsanjani; Hunaifi, Ilsa
Research of Service Administration Health and Sains Healthys Vol 6, No 2 (2025): Research of Service Administration Health and Sains Healthys (Desember)
Publisher : Lembaga Penelitian dan Pendidikan (LPP) Mandala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58258/rehat.v6i2.9784

Abstract

Acute ischemic stroke triggers a complex neuroinflammatory response involving resident glial cells, particularly microglia and astrocytes. Microglia rapidly activate following ischemia and polarize into two main phenotypes: the pro-inflammatory M1 phenotype, which exacerbates neuronal damage through the release of cytokines like TNF-α, IL-1β, and reactive oxygen species (ROS), and the anti-inflammatory M2 phenotype, which promotes tissue repair via IL-10 and IL-4 secretion. Astrocytes also play a dual role: in the acute phase, they exert neuroprotective effects by regulating glutamate homeostasis, producing antioxidants (e.g., glutathione and superoxide dismutase), and supporting neurogenesis and angiogenesis; however, in the chronic phase, reactive astrocytes contribute to glial scar formation, which inhibits axonal regeneration. The dynamic interplay between microglia and astrocytes critically shapes the neuroinflammatory milieu—determining whether the response is protective or detrimental. Understanding these dual roles offers promising avenues for developing neuroprotective therapies targeting neuroinflammation after acute ischemic stroke.
Co-Authors Abtartu, Lalu Hizrian Ilsa Hunaifi, Ilsa Jayawardhana, I Ketut Wisnuaji Qomala, Dianing Aluh