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All Journal Dentino: Jurnal Kedokteran Gigi Prosiding Seminar Nasional COSMIC Kedokteran
Rahma, Aline Febridha
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Dentistry Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Physics Public Health

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ROKOK ELEKTRIK SEBAGAI FAKTOR RISIKO PERIODONTITIS: KAJIAN LITERATUR BERDASARKAN BUKTI KLINIS DAN BIOLOGIS Rahma, Aline Febridha; Parmasari, Wahyuni Dyah; Sutandio, Yunitati; Sanjaya, Ayling
Prosiding Seminar Nasional COSMIC Kedokteran Vol 4 (2026): Edisi 2026
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat Universitas Wijaya Kusuma Surabaya

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Abstract

Latar Belakang: Penggunaan rokok elektrik (e-cigarette) semakin meningkat di kalangan remaja dan dewasa muda. Meskipun sering dianggap lebih aman dibanding rokok konvensional, e-cigarette tetap mengandung zat yang berpotensi merusak jaringan mulut, terutama jaringan periodontal. Tujuan: Kajian ini bertujuan untuk menelaah secara sistematis dampak penggunaan e-cigarette terhadap kesehatan periodontal. Metode: Penelusuran dilakukan terhadap artikel ilmiah yang terbit dalam lima tahun terakhir (2020–2025) melalui basis data Google Scholar, ScienceDirect, dan PLOS Global Public Health. Sebanyak 15 artikel yang memenuhi kriteria inklusi dianalisis, terdiri dari studi observasional, tinjauan sistematis, dan meta-analisis. Hasil: Penggunaan e-cigarette dikaitkan dengan peningkatan kedalaman poket periodontal (PPD), kehilangan perlekatan klinis (CAL), resorpsi tulang marginal (MBL), serta kadar sitokin proinflamasi IL-1B yang lebih tinggi dibandingkan non-smoker. Dampaknya lebih ringan dibanding rokok konvensional, namun tetap memicu inflamasi, perubahan mikrobioma oral, dan gangguan penyembuhan jaringan. Respons terapi peri-implantitis juga lebih buruk pada pengguna e-cigarette. Kesimpulan: Berdasarkan telaah terhadap lima belas publikasi ilmiah yang dikaji, dapat disimpulkan bahwa penggunaan rokok elektrik (e-cigarette) memiliki dampak yang nyata terhadap kesehatan periodontal. Meskipun beberapa studi menunjukkan bahwa efeknya tidak seberat rokok konvensional, e-cigarette tetap berkontribusi terhadap perubahan klinis dan biologis yang relevan. Kandungan kimia dalam cairan e-cigarette juga berpotensi memicu stres oksidatif dan gangguan komposisi saliva. Oleh karena itu, penting bagi tenaga kesehatan gigi untuk mempertimbangkan riwayat penggunaan e-cigarette dalam proses anamnesis dan perencanaan terapi, serta memberikan edukasi yang tepat kepada pasien. Penelitian longitudinal dengan kontrol yang ketat masih diperlukan untuk memahami dampak jangka panjangnya terhadap kesehatan mulut secara menyeluruh.
ELEVATED INTERLEUKIN-6 AND COTININE LEVELS FOLLOWING ELECTRONIC CIGARETTE EXPOSURE: STUDY IN VIVO Rahma, Aline Febridha; Parmasari, Wahyuni Dyah; Margaretha Sutandio, Yunitati Maria; Sanjaya, Ayling
Dentino: Jurnal Kedokteran Gigi Vol 11, No 1 (2026)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v11i1.26096

Abstract

Background: Periodontitis is a chronic inflammatory disease affecting the supporting tissues of the teeth. Animal models are commonly used to study its pathogenesis and the effects of various exposures. E-cigarette vapor contains nicotine and other harmful substances that may induce inflammation. Cotinine and interleukin-6 (IL-6) serve as biomarkers of nicotine exposure and inflammatory response. Purpose: This study aimed to evaluate cotinine and IL-6 levels in Wistar rats exposed to e-cigarette vapor and to assess the relationship between nicotine exposure and systemic inflammation in periodontitis. Methods: Twelve Wistar rats were divided into treatment and control groups. The treatment group was exposed to e-cigarette vapor for 35 days (30 puffs/day), while the control group received no exposure. Cotinine and IL-6 levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). Independent t-tests and Pearson correlation analyses were performed. Results : The treatment group exposed to e-cigarette vapor showed higher IL-6 and cotinine levels compared to the control group. The mean for IL-6 was 27,5 pg/mL (treatment group) and 13,8 pg/mL (control group), while for cotinine it was 227,6 ng/mL (treatment group) and 175,4 ng/mL (control group). A positive correlation was observed (r = 0.515; p = 0.086), although this did not reach statistical significance. Conclusion: E-cigarette vapor exposure increased cotinine and IL-6 levels in Wistar rats, indicating enhanced systemic inflammation. However, these findings should be interpreted with caution due to the small sample size and animal model. Further studies involving larger samples and human subjects are needed to confirm these results and determine their clinical relevance.Keywords: Cotinine, Electronic_Cigarette, Interleukin-6, Periodontitis
Co-Authors Ayling Sanjaya Margaretha Sutandio, Yunitati Maria Sutandio, Yunitati Wahyuni Dyah Parmasari, Wahyuni Dyah