Articles
<![CDATA[ADDISONS DISEASE ]]>
<![CDATA[Sanjaya, Ayling]]>
<![CDATA[ Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 1, No 1 (2012): Edisi Juli 2012 ]]>
Publisher : <![CDATA[Universitas Wijaya Kusuma Surabaya ]]>
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<![CDATA[Penyakit Addison (Addisons disease) adalah kelainan yang disebabkan oleh ketidakmampuan korteks adrenalis memproduksi hormon kortisol dan aldosteron. Keadaan tersebut dapat disebabkan oleh insufisiensi adrenal primer seperti autoimun, infeksi dan tumor adrenal atau insufisiensi adrenal sekunder karena tumor atau infeksi, kurangnya aliran darah ke kelenjar hipofisis, radiasi kelenjar hipofisis, atau pengangkatan bagian hipotalamus atau kelenjar hipofisis. Penyakit Addison ini sangat jarang terutama pada anak-anak. Penyakit Addison dapat terjadi baik pada pria maupun wanita di semua usia. Frekuensi penyakit Addison pada populasi manusia diperkirakan 1 dari 100.000. Diagnosis penyakit Addison dapat dibuat melalui gambaran klinis dan pemeriksaan laboratorium. Pemeriksaan radiologis seperti CT Scan dan MRI dapat membantu menganalisa kelenjar adrenal dan kelenjar hipofise sehingga dapat diketahui penyebab insufisiensi kortisol yang terjadi pada penderita. Terapi penyakit Addison yaitu penggantian atau subtitusi hormon kortisol memperbaiki defisiensi glukokortikoid dan terapi standar pada keadaan krisis Addison. Diagnosis dini dan terapi yang tepat diperlukan untuk memberikan prognosis yang baik bagi pasien Addisons disease.]]>
<![CDATA[PROFILE OF TETANUS IN CHILDREN AT PROF.KANDOU HOSPITAL 2002-2008 ]]>
<![CDATA[Sanjaya, Ayling]]>;
<![CDATA[Rampengan, Novie Homenta]]>;
<![CDATA[Rampengan, Tommy Homenta]]>
<![CDATA[ Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 1 (2013): Edisi Mei 2013 ]]>
Publisher : <![CDATA[Universitas Wijaya Kusuma Surabaya ]]>
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<![CDATA[Backgrounds. Tetanus or lockjaw is an acute disease dwelling central nervous system caused by tetanoplasmin toxin produced by Clostridium tetani. Muscle spasm without consciousness disorder is distinguishing symptoms of tetanus. Tetanus in children remains as a health problem in developing countries including Indonesia.Objectives. To study the profile of tetanus in children.Methods. Retrospective review of children diagnosed as tetanus at Prof. Dr. R.D.Kandou Hospital from 2002 to 2008. The datas were analyzed descriptively.Results. There were 17 children with tetanus with age range 1-8 years, 12 males and 5 females. Seven of them had no tetanus immunization dan the rest of children with immunization never got booster immunization . Twelve children had otitis media and 5 children had untreated wound on their lower extremities as focus of infections. Period of getting wounded until symptoms appeared is approximately 3 days to 1 month.Common symptoms are trismus, convulsion, fever, opistotonus in all children. Complications such as bronchopneumonia occurred in 5 children, 4 children with severe tetanus and complications died in 19 hours to 18 days of treatment and the rest of 8 children had no complications.Conclusions. Tetanus in children remains as health problem. Promoting prevention awareness in community and health providers is very important to decrease tetanus mortality and morbidity in children. ]]>
<![CDATA[microRNA as Potential Biomarker for Pediatric Tuberculosis? ]]>
<![CDATA[Ayling Sanjaya1, Dwi Yuni Nur Hidayati2, Susanthy Djajalaksana3, HMS Chandra Kusuma4]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
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DOI: 10.37506/ijfmt.v14i2.3507
<![CDATA[The diagnosis of pediatric TB is based on history taking, clinical symptoms, physical examination and support. In recent years the role of microRNA (miRNA or miR) has become a concern for researchers as biomarkers of diagnosis and therapy in TB in adults and children. MicroRNA is a ribonucleic acid that does not encode proteins with 18-25 nucleotide transcripts that interact with gene targets and regulate mRNA expression. miRNA works with other regulatory elements such as transcription factors to control mRNA translation. More than 100 different miRNAs are expressed by immune system cells; they have the potential to broadly influence the molecular pathways that control the development and function of innate and adaptive immune response regulation. During TB infection, the innate immune response provides an initial defense mechanism against infection. It is well known that macrophages are the main stem cells for mycobacteria, survival in macrophages is determined by host-pathogen interactions. Several studies have shown that miRNA can be used as a biomarker and TB therapy agent because it is stable in plasma and other body fluids, difficult to degrade and excreted in the form of exosomes or micro vesicles. Other studies say miRNA is stable despite repeated exposure to heat, cold, acids, bases, and other extreme conditions. microRNA levels are reported to be increased in individuals with TB.]]>
<![CDATA[Determinant Factors on Active and Latent Tuberculosis among Children in Surabaya ]]>
<![CDATA[Ayling Sanjaya1, Dwi Yuni Nur Hidayati2, Susanthy Djajalaksana3, HMS Chandra Kusuma4]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
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DOI: 10.37506/ijfmt.v14i2.3509
<![CDATA[Background: Pediatric tuberculosis (TB) is a major health problem in the world and Indonesia. The difficulty of diagnosis is a major factor in eradicating TB in children. Active and latent tuberculosis in children often shows no symptoms so it is difficult to diagnose and affect the treatment. Several determinant factors need to be assessed with the hope of optimal handling of TB in children. Objective: To analyze the determinant factors on active and latent tuberculosis among children in Surabaya. Methods: A case control study was done with 25 cases with TB divided into active TB, Latent TB. Pulmonary tuberculosis was diagnosed using the Indonesian Pediatric Tuberculosis Scoring System. Determinant factors for tuberculosis development were history of contact with a TB patient, age, BCG immunization, knowledge, socioeconomic status and overcrowding living condition. Analysis was done using Fisher’s Exact and Mann-Whitney test. Findings: The characteristics of the study subjects consisting of 16 active TB children and 9 latent TB children. In the group of active TB children the largest population is girls (11 children), whereas in the latent TB group are boys (8 children). There was a significant difference between groups of active TB children and latent TB children (p = 0.000 <0.05). The other factors are showing nothing different in the both of group TB. Conclusion: The most significant determinant factor in active TB and latent TB in children is the appearance infiltrate of chest X-ray where active TB shows filtration and normal appearance in latent TB.]]>
<![CDATA[Toxoplasma gondii immunoglobulin G in paired infant-and-mother sera ]]>
<![CDATA[Ayling Sanjaya]]>;
<![CDATA[Nurhayati Masloman]]>;
<![CDATA[Rocky Wilar]]>;
<![CDATA[Josef Tuda]]>
<![CDATA[ Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009 ]]>
Publisher : <![CDATA[Indonesian Pediatric Society ]]>
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DOI: 10.14238/pi49.2.2009.65-8
<![CDATA[Background Toxoplasmosis is a worldwide zoonotic diseasecaused by Toxoplasma gondii. Congenital toxoplasmosis (CT)is the result of vertical transmission during pregnancy thatmay cause pathologic effects on the newborn such as classicaltriad of congenital toxoplasmosis. Newborn humans are notimmunologically competent and the infant must be protected by passive lgG antibodies that are selectively transported across the placenta during development. We studied the transfer of passive lgG from the mother to developing infant using blood specimen taken from the infant within one month of birth.Objective To determine the seropositivity of lgG to T. gondii in paired sera of infants and mothers.Methods A cross sectional study was carried out on 50 pairedsera of infants of less than one month of age and their mothers. The study was carried out between November 2007 and January 2008 at Prof. R. D. Kandou Hospital in Manado. T. gondii lgG was detected using the Latex Agglutination method. The seropositivity ofT. gondii lgG was analyzed descriptively.Results A total of 28 mothers from 50 infant-mother pairs wereseropositive for T. gondii IgG. Of the 28 seropositive mothers, 22 of their paired infants were seropositive. The remaining six seropositive mothers had infants that were not seropositive for T. gondii.Conclusions The identification of seropositive lgG for T. gondii in infants less than one months age indicates that the lgGs in infants are mostly derived from their mothers. CT must be considered and further examinations are needed.]]>
<![CDATA[Identification of Microrna in Pediatric Latent Tuberculosis: A Preliminary Study in Indonesia ]]>
<![CDATA[Ayling Sanjaya]]>
<![CDATA[ Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020 ]]>
Publisher : <![CDATA[Journal of Global Pharma Technology ]]>
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<![CDATA[Background: Pediatric tuberculosis (TB) is a major health problem in the world and Indonesia. Latent tuberculosis infection (LTBI) in children can be developed in to active state. It is difficult to prevent LTBI due to the lack of specific and diagnostic biomarkers. Research of microRNA (miRNA) conducted to identify profile of miRNA expression among pediatric LTBI specifically in Indonesia. This suggests that miRNA can be one of the tools to diagnose LTBI in children that needs to be developed. Aims: To identify specific miRNA expression in Indonesian pediatric latent tuberculosis infection. Methods: This research was an observational analytic study using a cross-sectional study design. The study used whole blood of healthy control children who had never received BCG immunization and children diagnosed LTBI. Profiling and identified miRNA expression with microarray analysis. Results: Four LTBI and two healthy control children were included in this study. Extraction of RNA with whole blood were done and profiled with gene chip microarray. Fold change >2 or]]>
<![CDATA[PROFILE OF TETANUS IN CHILDREN AT PROF.KANDOU HOSPITAL 2002-2008 ]]>
<![CDATA[Ayling Sanjaya]]>;
<![CDATA[Novie Homenta Rampengan]]>;
<![CDATA[Tommy Homenta Rampengan]]>
<![CDATA[ Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 1 (2013): Edisi Mei 2013 ]]>
Publisher : <![CDATA[Universitas Wijaya Kusuma Surabaya ]]>
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DOI: 10.30742/jikw.v2i1.43
<![CDATA[Backgrounds. Tetanus or lockjaw is an acute disease dwelling central nervous system caused by tetanoplasmin toxin produced by Clostridium tetani. Muscle spasm without consciousness disorder is distinguishing symptoms of tetanus. Tetanus in children remains as a health problem in developing countries including Indonesia.Objectives. To study the profile of tetanus in children.Methods. Retrospective review of children diagnosed as tetanus at Prof. Dr. R.D.Kandou Hospital from 2002 to 2008. The datas were analyzed descriptively.Results. There were 17 children with tetanus with age range 1-8 years, 12 males and 5 females. Seven of them had no tetanus immunization dan the rest of children with immunization never got booster immunization . Twelve children had otitis media and 5 children had untreated wound on their lower extremities as focus of infections. Period of getting wounded until symptoms appeared is approximately 3 days to 1 month.Common symptoms are trismus, convulsion, fever, opistotonus in all children. Complications such as bronchopneumonia occurred in 5 children, 4 children with severe tetanus and complications died in 19 hours to 18 days of treatment and the rest of 8 children had no complications.Conclusions. Tetanus in children remains as health problem. Promoting prevention awareness in community and health providers is very important to decrease tetanus mortality and morbidity in children.]]>
<![CDATA[ADDISON'S DISEASE ]]>
<![CDATA[Ayling Sanjaya]]>
<![CDATA[ Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 1, No 1 (2012): Edisi Juli 2012 ]]>
Publisher : <![CDATA[Universitas Wijaya Kusuma Surabaya ]]>
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DOI: 10.30742/jikw.v1i1.51
<![CDATA[Penyakit Addison (Addison's disease) adalah kelainan yang disebabkan oleh ketidakmampuan korteks adrenalis memproduksi hormon kortisol dan aldosteron. Keadaan tersebut dapat disebabkan oleh insufisiensi adrenal primer seperti autoimun, infeksi dan tumor adrenal atau insufisiensi adrenal sekunder karena tumor atau infeksi, kurangnya aliran darah ke kelenjar hipofisis, radiasi kelenjar hipofisis, atau pengangkatan bagian hipotalamus atau kelenjar hipofisis. Penyakit Addison ini sangat jarang terutama pada anak-anak. Penyakit Addison dapat terjadi baik pada pria maupun wanita di semua usia. Frekuensi penyakit Addison pada populasi manusia diperkirakan 1 dari 100.000. Diagnosis penyakit Addison dapat dibuat melalui gambaran klinis dan pemeriksaan laboratorium. Pemeriksaan radiologis seperti CT Scan dan MRI dapat membantu menganalisa kelenjar adrenal dan kelenjar hipofise sehingga dapat diketahui penyebab insufisiensi kortisol yang terjadi pada penderita. Terapi penyakit Addison yaitu penggantian atau subtitusi hormon kortisol memperbaiki defisiensi glukokortikoid dan terapi standar pada keadaan krisis Addison. Diagnosis dini dan terapi yang tepat diperlukan untuk memberikan prognosis yang baik bagi pasien Addison's disease.]]>
<![CDATA[Anti-Proliferative Compound Candidate of White Turmeric (Curcuma zedoaria) ]]>
<![CDATA[Putu Oky Ari Tania]]>;
<![CDATA[Candra Rini Hasanah Putri]]>;
<![CDATA[Ayling Sanjaya]]>;
<![CDATA[Titiek Sunaryati]]>;
<![CDATA[Deddy Hartanto]]>;
<![CDATA[Erlix R Purnama]]>;
<![CDATA[Meivy Isnoviana]]>
<![CDATA[ Biota Vol 9 No 2 (2023): Jurnal Biota 2023 ]]>
Publisher : <![CDATA[Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang ]]>
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DOI: 10.19109/Biota.v9i2.13746
<![CDATA[Malignant disease or cancer progression burden the community after decades. This tumor formation or tumorigenesis involves cell proliferation. Protein Kinases (MAPK9s) is key proteins of regulating the growth and viability of cells physiologically and pathologically. Rhizomes of Curcuma zedoaria or zedoary or white turmeric is used as a health supplement. The aim of this study was to obtained candidate proteins for anti-proliferative using the docking method between the protein MAPK9 and the active compound obtained from the crude extract of white turmeric i.e. demethoxycurcumin, curcumenol and germacrone. The result s hows that complex MAPK-demethoxycurcumin have the lowest binding affinity -8.4 Kkal/mol, while MAPK-curcumenol was -8 Kkal/mol, and MAPK-Germacrone was -6.2 Kkal/mol, it determined the potential activity cell proliferation.]]>
<![CDATA[Optimalisasi Kesehatan Mental dan Perilaku Remaja Menuju Generasi Unggul Melalui Penyuluhan Siswa-Siswi SMPN 8 Surabaya - Jawa Timur ]]>
<![CDATA[Ayling Sanjaya]]>;
<![CDATA[Anna Lewi Santoso]]>;
<![CDATA[Haryson Tondy Winoto]]>;
<![CDATA[James Hadiputra Sunarpo]]>;
<![CDATA[Made Ayu Prasasti Dwitama Putri]]>
<![CDATA[ Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 8 No 1 (2024): Volume 8 Nomor 1 Tahun 2024 ]]>
Publisher : <![CDATA[Universitas Nusantara PGRI Kediri ]]>
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DOI: 10.29407/ja.v8i1.21624
<![CDATA[Permasalahan mental dan perilaku pada remaja masih menjadi masalah yang serius di dunia dan di Indonesia. Gangguan mental dan perilaku pada remaja sering tidak terdeteksi dan terabaikan dalam penanganannya sehingga berisiko dalam pembentukan karakter menuju dewasa serta mempengaruhi kualitas dan masa depannya sehingga perlu penyuluhan dan sosialisasi. Tujuan Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan informasi mengenai pentingnya optimalisasi kesehatan mental dan perilaku remaja bagi masa depan menuju generasi unggul. Metode Pengabdian masyarakat dilakukan pada remaja berupa penyuluhan kepada remaja mengenai pentingnya optimalisasi kesehatan mental dan perilaku demi menjadi generasi unggul dan memiliki masa depan yang baik Pelaksanaan kegiatan ini meliputi ceramah dalam bentuk presentasi, diskusi, dan konseling. Pre-test dan post-test dilakukan sebelum dan sesudah kegiatan ini. Sebanyak 600 peserta mengikuti kegiatan ini, diantaranya, Kepala Sekolah, Guru, dan Siswa SMPN 8 Surabaya. Hasil Ditemukan sebanyak 309 (68,7%) siswa remaja merasa memiliki masalah dengan keluarga, sekolah ataupun teman. Terdapat peningkatan kemampuan peserta dalam kesadaran pentingnya optimalisasi kesehatan mental dan perilaku remaja setelah dilakukan penyuluhan di mana terjadi peningkatan peserta dengan nilai nilai baik di post-test meningkat dibandingkan pre-test. Ringkasan Penyuluhan mengenai optimalisasi kesehatan mental dan perilaku remaja menuju generasi unggul sangat efektif.]]>
