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Ayling Sanjaya
Bagian Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
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ADDISONS DISEASE Sanjaya, Ayling
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 1, No 1 (2012): Edisi Juli 2012
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Penyakit Addison (Addisons disease) adalah kelainan yang disebabkan oleh ketidakmampuan korteks adrenalis memproduksi hormon kortisol dan aldosteron. Keadaan tersebut dapat disebabkan oleh insufisiensi adrenal primer seperti autoimun, infeksi dan tumor adrenal atau insufisiensi adrenal sekunder karena tumor atau infeksi, kurangnya aliran darah ke kelenjar hipofisis, radiasi kelenjar hipofisis, atau pengangkatan bagian hipotalamus atau kelenjar hipofisis. Penyakit Addison ini sangat jarang terutama pada anak-anak. Penyakit Addison dapat terjadi baik pada pria maupun wanita di semua usia. Frekuensi penyakit Addison pada populasi manusia diperkirakan 1 dari 100.000. Diagnosis penyakit Addison dapat dibuat melalui gambaran klinis dan pemeriksaan laboratorium. Pemeriksaan radiologis seperti CT Scan dan MRI dapat membantu menganalisa kelenjar adrenal dan kelenjar hipofise sehingga dapat diketahui penyebab insufisiensi kortisol yang terjadi pada penderita. Terapi penyakit Addison yaitu penggantian atau subtitusi hormon kortisol memperbaiki defisiensi glukokortikoid dan terapi standar pada keadaan krisis Addison. Diagnosis dini dan terapi yang tepat diperlukan untuk memberikan prognosis yang baik bagi pasien Addisons disease.
PROFILE OF TETANUS IN CHILDREN AT PROF.KANDOU HOSPITAL 2002-2008 Sanjaya, Ayling; Rampengan, Novie Homenta; Rampengan, Tommy Homenta
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 1 (2013): Edisi Mei 2013
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Backgrounds. Tetanus or lockjaw is an acute disease dwelling central nervous system caused by tetanoplasmin toxin produced by Clostridium tetani. Muscle spasm without consciousness disorder is distinguishing symptoms of tetanus. Tetanus in children remains as a health problem in developing countries including Indonesia.Objectives.  To study the profile of tetanus in children.Methods. Retrospective review of children diagnosed as tetanus at Prof. Dr. R.D.Kandou Hospital from 2002 to 2008. The datas were analyzed descriptively.Results.  There were 17 children with tetanus with age range 1-8 years, 12 males and 5 females. Seven of them had no tetanus immunization dan the rest of children with immunization never got booster immunization . Twelve children had otitis media and 5 children had untreated wound on their lower extremities as focus of infections. Period of getting wounded until symptoms appeared is approximately 3 days to 1 month.Common symptoms are trismus, convulsion, fever, opistotonus in all children. Complications such as bronchopneumonia occurred in 5 children, 4 children with severe tetanus and complications died in 19 hours to 18 days of treatment and the rest of 8 children had no complications.Conclusions.  Tetanus in children remains as health problem. Promoting prevention awareness in community and health providers is very important to decrease tetanus mortality and morbidity in children.
microRNA as Potential Biomarker for Pediatric Tuberculosis? Ayling Sanjaya1, Dwi Yuni Nur Hidayati2, Susanthy Djajalaksana3, HMS Chandra Kusuma4
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3507

Abstract

The diagnosis of pediatric TB is based on history taking, clinical symptoms, physical examination and support. In recent years the role of microRNA (miRNA or miR) has become a concern for researchers as biomarkers of diagnosis and therapy in TB in adults and children. MicroRNA is a ribonucleic acid that does not encode proteins with 18-25 nucleotide transcripts that interact with gene targets and regulate mRNA expression. miRNA works with other regulatory elements such as transcription factors to control mRNA translation. More than 100 different miRNAs are expressed by immune system cells; they have the potential to broadly influence the molecular pathways that control the development and function of innate and adaptive immune response regulation. During TB infection, the innate immune response provides an initial defense mechanism against infection. It is well known that macrophages are the main stem cells for mycobacteria, survival in macrophages is determined by host-pathogen interactions. Several studies have shown that miRNA can be used as a biomarker and TB therapy agent because it is stable in plasma and other body fluids, difficult to degrade and excreted in the form of exosomes or micro vesicles. Other studies say miRNA is stable despite repeated exposure to heat, cold, acids, bases, and other extreme conditions. microRNA levels are reported to be increased in individuals with TB.
Determinant Factors on Active and Latent Tuberculosis among Children in Surabaya Ayling Sanjaya1, Dwi Yuni Nur Hidayati2, Susanthy Djajalaksana3, HMS Chandra Kusuma4
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3509

Abstract

Background: Pediatric tuberculosis (TB) is a major health problem in the world and Indonesia. The difficulty of diagnosis is a major factor in eradicating TB in children. Active and latent tuberculosis in children often shows no symptoms so it is difficult to diagnose and affect the treatment. Several determinant factors need to be assessed with the hope of optimal handling of TB in children. Objective: To analyze the determinant factors on active and latent tuberculosis among children in Surabaya. Methods: A case control study was done with 25 cases with TB divided into active TB, Latent TB. Pulmonary tuberculosis was diagnosed using the Indonesian Pediatric Tuberculosis Scoring System. Determinant factors for tuberculosis development were history of contact with a TB patient, age, BCG immunization, knowledge, socioeconomic status and overcrowding living condition. Analysis was done using Fisher’s Exact and Mann-Whitney test. Findings: The characteristics of the study subjects consisting of 16 active TB children and 9 latent TB children. In the group of active TB children the largest population is girls (11 children), whereas in the latent TB group are boys (8 children). There was a significant difference between groups of active TB children and latent TB children (p = 0.000 <0.05). The other factors are showing nothing different in the both of group TB. Conclusion: The most significant determinant factor in active TB and latent TB in children is the appearance infiltrate of chest X-ray where active TB shows filtration and normal appearance in latent TB.
Toxoplasma gondii immunoglobulin G in paired infant-and-mother sera Ayling Sanjaya; Nurhayati Masloman; Rocky Wilar; Josef Tuda
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.829 KB) | DOI: 10.14238/pi49.2.2009.65-8

Abstract

Background  Toxoplasmosis  is  a worldwide zoonotic diseasecaused  by  Toxoplasma  gondii.  Congenital toxoplasmosis (CT)is  the  result  of  vertical transmission  during  pregnancy  thatmay cause pathologic effects  on  the newborn such  as  classicaltriad  of  congenital toxoplasmosis.  Newborn  humans  are  notimmunologically  competent  and the infant must be protected  by passive lgG antibodies  that  are selectively transported across the placenta during development.  We  studied the transfer  of  passive lgG from the  mother  to developing infant using blood specimen taken from the infant within one  month  of  birth.Objective  To  determine the seropositivity  of  lgG to  T.  gondii  in paired sera  of  infants and mothers.Methods  A cross sectional study was carried  out  on  50 pairedsera  of  infants  of  less  than  one  month  of  age and their mothers. The  study was carried  out  between November 2007 and January 2008  at  Prof.  R.  D.  Kandou Hospital in Manado.  T.  gondii  lgG was detected using the Latex Agglutination method.  The  seropositivity ofT.  gondii  lgG was analyzed descriptively.Results  A total  of  28 mothers from 50 infant-mother pairs wereseropositive for  T.  gondii  IgG.  Of  the 28 seropositive mothers, 22  of their paired infants were seropositive.  The  remaining six seropositive mothers  had  infants  that  were  not  seropositive for T.  gondii.Conclusions  The  identification  of  seropositive lgG for  T.  gondii in infants less  than  one  months  age indicates  that  the lgGs in infants are mostly derived from their mothers.  CT  must be considered  and  further  examinations  are needed.
Identification of Microrna in Pediatric Latent Tuberculosis: A Preliminary Study in Indonesia Ayling Sanjaya
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Pediatric tuberculosis (TB) is a major health problem in the world and Indonesia. Latent tuberculosis infection (LTBI) in children can be developed in to active state. It is difficult to prevent LTBI due to the lack of specific and diagnostic biomarkers. Research of microRNA (miRNA) conducted to identify profile of miRNA expression among pediatric LTBI specifically in Indonesia. This suggests that miRNA can be one of the tools to diagnose LTBI in children that needs to be developed. Aims: To identify specific miRNA expression in Indonesian pediatric latent tuberculosis infection. Methods: This research was an observational analytic study using a cross-sectional study design. The study used whole blood of healthy control children who had never received BCG immunization and children diagnosed LTBI. Profiling and identified miRNA expression with microarray analysis. Results: Four LTBI and two healthy control children were included in this study. Extraction of RNA with whole blood were done and profiled with gene chip microarray. Fold change >2 or
PROFILE OF TETANUS IN CHILDREN AT PROF.KANDOU HOSPITAL 2002-2008 Ayling Sanjaya; Novie Homenta Rampengan; Tommy Homenta Rampengan
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 1 (2013): Edisi Mei 2013
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v2i1.43

Abstract

Backgrounds. Tetanus or lockjaw is an acute disease dwelling central nervous system caused by tetanoplasmin toxin produced by Clostridium tetani. Muscle spasm without consciousness disorder is distinguishing symptoms of tetanus. Tetanus in children remains as a health problem in developing countries including Indonesia.Objectives.  To study the profile of tetanus in children.Methods. Retrospective review of children diagnosed as tetanus at Prof. Dr. R.D.Kandou Hospital from 2002 to 2008. The datas were analyzed descriptively.Results.  There were 17 children with tetanus with age range 1-8 years, 12 males and 5 females. Seven of them had no tetanus immunization dan the rest of children with immunization never got booster immunization . Twelve children had otitis media and 5 children had untreated wound on their lower extremities as focus of infections. Period of getting wounded until symptoms appeared is approximately 3 days to 1 month.Common symptoms are trismus, convulsion, fever, opistotonus in all children. Complications such as bronchopneumonia occurred in 5 children, 4 children with severe tetanus and complications died in 19 hours to 18 days of treatment and the rest of 8 children had no complications.Conclusions.  Tetanus in children remains as health problem. Promoting prevention awareness in community and health providers is very important to decrease tetanus mortality and morbidity in children.
ADDISON'S DISEASE Ayling Sanjaya
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 1, No 1 (2012): Edisi Juli 2012
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.294 KB) | DOI: 10.30742/jikw.v1i1.51

Abstract

Penyakit Addison (Addison's disease) adalah kelainan yang disebabkan oleh ketidakmampuan korteks adrenalis memproduksi hormon kortisol dan aldosteron. Keadaan tersebut dapat disebabkan oleh insufisiensi adrenal primer seperti autoimun, infeksi dan tumor adrenal atau insufisiensi adrenal sekunder karena tumor atau infeksi, kurangnya aliran darah ke kelenjar hipofisis, radiasi kelenjar hipofisis, atau pengangkatan bagian hipotalamus atau kelenjar hipofisis. Penyakit Addison ini sangat jarang terutama pada anak-anak. Penyakit Addison dapat terjadi baik pada pria maupun wanita di semua usia. Frekuensi penyakit Addison pada populasi manusia diperkirakan 1 dari 100.000. Diagnosis penyakit Addison dapat dibuat melalui gambaran klinis dan pemeriksaan laboratorium. Pemeriksaan radiologis seperti CT Scan dan MRI dapat membantu menganalisa kelenjar adrenal dan kelenjar hipofise sehingga dapat diketahui penyebab insufisiensi kortisol yang terjadi pada penderita. Terapi penyakit Addison yaitu penggantian atau subtitusi hormon kortisol memperbaiki defisiensi glukokortikoid dan terapi standar pada keadaan krisis Addison. Diagnosis dini dan terapi yang tepat diperlukan untuk memberikan prognosis yang baik bagi pasien Addison's disease.
Anti-Proliferative Compound Candidate of White Turmeric (Curcuma zedoaria) Putu Oky Ari Tania; Candra Rini Hasanah Putri; Ayling Sanjaya; Titiek Sunaryati; Deddy Hartanto; Erlix R Purnama; Meivy Isnoviana
Biota Vol 9 No 2 (2023): Jurnal Biota 2023
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/Biota.v9i2.13746

Abstract

Malignant disease or cancer progression burden the community after decades. This tumor formation or tumorigenesis involves cell proliferation. Protein Kinases (MAPK9s) is key proteins of regulating the growth and viability of cells physiologically and pathologically. Rhizomes of Curcuma zedoaria or zedoary or white turmeric is used as a health supplement. The aim of this study was to obtained candidate proteins for anti-proliferative using the docking method between the protein MAPK9 and the active compound obtained from the crude extract of white turmeric i.e. demethoxycurcumin, curcumenol and germacrone. The result s hows that complex MAPK-demethoxycurcumin have the lowest binding affinity -8.4 Kkal/mol, while MAPK-curcumenol was -8 Kkal/mol, and MAPK-Germacrone was -6.2 Kkal/mol, it determined the potential activity cell proliferation.
PENCEGAHAN DAN PENANGANAN BALITA STUNTING MELALUI PEMAHAMAN SERTA IMPLEMENTASI BUKU KESEHATAN IBU DAN ANAK (KIA) OLEH IBU BALITA DAN KADER DI DESA BANARAN, KABUPATEN NGANJUK, JAWA TIMUR Irwanto Irwanto; Risky Vitria Prasetyo; Hanna Dyahferi Anomsari; Ayling Sanjaya; Egi Azhar Rafsanjani; Firyal Nadiah Rahmah
Jurnal Abdi Insani Vol 10 No 4 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i4.1157

Abstract

Stunting is still a problem around the world, particularly Indonesia where the prevalence of stunting in 2020 was 26.92%. The short-term impact of stunting included an increased risk of morbidity and mortality due to infectious diseases, while, long-term impacts of stunting can cause obesity, impaired cognitive function, and work productivity. One of the efforts to prevent stunting is the use of the Maternal and Child Health (MCH) Handbook by pregnant women and children aged under 5 years which has not been implemented properly. This community service activity aims to provide training in filling out the MCH handbook and educate the public on the importance of monitoring stunting in babies and children. Methods for implementing this activity include lecture in presentation form, discussion, and training approaches. A pre-test and post-test were carried out before and after this activity. A total of 80 participants took part in this activity, including the Head of Kertosono District, the Head of Banaran Village, the Head of the Kertosono Community Health Center and his staff, health cadres, and mothers who have stunted children, consisting of 37 Banaran's health cadres and mothers with stunted toddlers (72% of total stunted children in Banaran). It was found that there was an increase in participants' ability to fill out the MCH Handbook; before the activity, the mean pre-test score was 77.03 ± 16.64 and the post-test score was 88.65 ± 12.508. Training in understanding how to fill out the MCH Handbook to prevent stunting is very effective.
Co-Authors Anna Lewi Santoso Anna Lewi Santoso Candra Rini Hasanah Putri Candra Rini Hasanah Putri Deddy Hartanto Egi Azhar Rafsanjani Erlix R Purnama Firyal Nadiah Rahmah Hamdan, Maulana Muhammad Hisyam Hanna Dyahferi Anomsari Haryson Tondy Winoto Ibrahim Njoto, Ibrahim Indria Dewi, Putu Agung Narendra Ira Idawati Irwanto Irwanto JAMES HADIPUTRA SUNARPO Jemima Lewi Santoso Josef Tuda Made Ayu Prasasti Dwitama Putri Meivy Isnoviana Nathania Lisna Ardelia Novie Homenta Rampengan Novie Homenta Rampengan, Novie Homenta Nur Khamidah Nurhayati Masloman Prameswari, Yaasmiin Zivana Regita Prasetyo, Mohammad Yudhi Putu Oky Ari Tania Risky Vitria Prasetyo Rocky Wilar Suryawati, Siany Titiek Sunaryati Titiek Sunaryati Tommy Homenta Rampengan Tommy Homenta Rampengan, Tommy Homenta Wahyuni Dyah Parmasari, Wahyuni Dyah