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All Journal Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Essentia: Journal of Medical Practice and Research
Rian Hendriyana Dwi Imanta
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Integrasi Presisi Profil Molekuler Radiologis dan Klinis dalam Diagnosis dan Penatalaksanaan Congenital Megacalyces Rian Hendriyana Dwi Imanta; Fairuz Rafi Fadlurrahman; Maya Ganda Ratna; Giska Tri Putri
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8158

Abstract

Congenital Megacalyces is a rare anomaly of the renal pelvis-calyceal system characterized by non-obstructive calyx dilatation due to renal medulla hypoplasia. This condition is often misinterpreted as hydronephrosis, leading to unnecessary surgical interventions. Advances in genomic technology and precision imaging have opened up opportunities to understand the molecular basis and anatomical structure of this anomaly more deeply. A literature review was conducted through PubMed, ScienceDirect, and Google Scholar, covering publications that discuss the relationship between genomics, imaging, and clinical management of congenital kidney abnormalities. The integration of Next Generation Sequencing (NGS), 3D MRI reconstruction imaging, and AI-based radiomics analysis has proven to enhance diagnostic accuracy, differentiate between obstructive and non-obstructive abnormalities, and assist in determining appropriate conservative therapies. Case studies demonstrate the association between SETBP1 mutations and the development of bilateral megacalyces, as well as the effectiveness of long-term monitoring based on multimodal data. The integration of genetic, imaging, and clinical data is a strategic step toward precision medicine in the management of Congenital Megacalyces. This approach improves diagnostic accuracy, reduces unnecessary invasive interventions, and supports individualized therapy based on genetic and anatomical risk factors.
Strategi Agromedicine untuk Pencegahan Fibrosis Paru pada Petani: Tinjauan Sistematis Modifikasi Alat Penyimpanan Gabah, Ventilasi Gudang, dan Efektivitas APD Respirator Rian Hendriyana Dwi Imanta; Indri Windarti; Laisa Azka; Andreas Infianto
Journal of Medical Practice and Research Vol 1 No 2 (2025): December: Essentia: Journal of Medical Practice and Research
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/pse66b22

Abstract

Pulmonary fibrosis is a progressive respiratory disease associated with chronic inhalation of respirable dust and bioaerosols, posing a substantial occupational health risk for agricultural workers. Farmers involved in grain storage and handling are frequently exposed to organic dust, fungal spores, and endotoxins that can induce persistent alveolar inflammation and irreversible fibrotic changes. This systematic review examines agromedicine-based prevention strategies focusing on grain storage modification, warehouse ventilation, and the effectiveness of respiratory protective equipment. Evidence indicates that improved storage design and controlled ventilation systems significantly reduce airborne particulate concentrations, thereby lowering cumulative inhalation exposure. Respiratory protective devices, particularly high-efficiency respirators, provide additional individual-level protection, although their real-world effectiveness is strongly influenced by user compliance, proper fitting, and training. The findings highlight that reliance on personal protective equipment alone is insufficient to prevent long-term pulmonary damage. An integrated prevention framework combining engineering controls, environmental management, and occupational health education is essential to reduce the burden of pulmonary fibrosis among farmers and promote sustainable agricultural health practices.    
Co-Authors Andreas Infianto Fairuz Rafi Fadlurrahman Giska Tri Putri Indri Windarti Laisa Azka Maya Ganda Ratna