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All Journal Nusantara Hasana Journal JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Hesti Yuningrum
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Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health

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Identifikasi Kandungan Senyawa Aktif Antibakteri Ekstrak Etanol 70% Bunga Cengkeh (Syzigium Aromaticum) Dalam Menghambat Pertumbuhan Bakteri Cutibacterium Acnes Ratu Restu Casayora; Hendra Tarigan Sibero; Hesti Yuningrum; Tri Umiana Soleha
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i2.1000

Abstract

Introduction: Acne (acne vulgaris) is caused by infection with the Cutibacterium acnes bacteria which is often treated with synthetic antibiotics, but long-term use can cause resistance. Clove flowers (Syzygium aromaticum) are known to contain active compounds such as eugenol, flavonoids, tannins and alkaloids which have the potential to act as natural antibacterials. This study aims to identify the active compound content and test the antibacterial activity of clove flower extract against C. acnes. Method: Experimental research was conducted using the post-test only control group design method. The bacterium used was Cutibacterium acnes. Clove flower powder was extracted with 70% ethanol using the maceration method, then tested for antibacterial activity using the well method. There were four concentration treatments: 25%, 50%, 75%, and 100%, alongside a positive control (clindamycin) and a negative control (aquadest). Results: Clove flower extract contains alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids. The Kruskal-Wallis statistical test results showing a significant difference (p < 0.001). Discussion: The antibacterial effectiveness of clove flowers is caused by the synergistic activity of active compounds, especially eugenol and tannin, which work by damaging cell membranes, inhibiting metabolic enzymes, and causing leakage of bacterial cell contents. Conclusion: Clove flower extract (Syzygium aromaticum) has strong antibacterial activity against Cutibacterium acnes.
PENGARUH KONSUMSI SERAT TERHADAP PROFIL LIPID DAN PENANDA INFLAMASI: TINJAUAN LITERATUR Simanjuntak, David Bryan Natanael; Dian Isti Angraini; Hesti Yuningrum; Dwita Oktaria
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1814

Abstract

Cardiometabolic diseases are a leading cause of global morbidity and mortality, with dyslipidemia and chronic low-grade inflammation playing key pathophysiological roles. Dietary factors, particularly dietary fiber intake, represent modifiable risk factors. This literature review aimed to evaluate the effects of dietary fiber consumption on lipid profiles and inflammatory markers. A systematic literature search was conducted using PubMed and Scopus with keywords related to dietary fiber, lipid profile, and inflammation. Of 157 identified articles, 8 met the inclusion criteria and were included in the analysis. The findings indicate that dietary fiber intake, especially soluble fiber, is consistently associated with reductions in total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride levels, particularly among individuals with type 2 diabetes mellitus, hyperlipidemia, and metabolic syndrome. In contrast, the effect of fiber on increasing high-density lipoprotein (HDL) cholesterol remains limited and inconsistent. Regarding inflammation, fiber consumption shows a more consistent anti-inflammatory effect on C-reactive protein (CRP), whereas its impact on proinflammatory cytokines such as interleukin-6 and tumor necrosis factor-α is variable. These differences may be influenced by fiber type, dosage, intervention duration, and participant characteristics. Overall, dietary fiber may serve as a safe and promising adjunct nutritional strategy for the prevention and management of cardiometabolic diseases.
Co-Authors Dian Isti Angraini Dwita Oktaria Hendra Tarigan Sibero Ratu Restu Casayora Simanjuntak, David Bryan Natanael Tri Umiana Soleha