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Terapi Gabapentin pada Pasien Herpes Zoster Oftalmikus Fase Akut: Neuralgia Paska Herpetika Iffat Taqiyah; Hendra Tarigan Sibero
Medula Vol 9 No 4 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i4.240

Abstract

Herpes zoster (HZ) is one of skin disease caused by viral infection, characterized by rash and pain, developed within unilateral dermatome consequence by Varicella Zoster Virus (VZV) reactivation in infected nerve. One of complication of HZ is pain that persists after the rash dissappears called postherpetic neuralgia (PHN). Postherpetic neuralgia can be predicted by people aged more than 50 years, severe prodromal symptoms, and severe acute pain of HZ. No treatment of prevention therapy for PHN has been shown but early therapy for reducing pain is expected for better outcome. Theory of early therapy of PHN has been still questionable. A 73-years old- women presenting with multiple blisters on her right forehead and eyelid accompanied by pain since 4 days ago. Dermatological status region of orbitalis and frontalis dextra, ophtalmic division of trigeminal nerve level appears pustules with erythematous base, circumscript, multiple, regular, lenticular, confluence, zoosteriform. Diagnosis of this case is herpes zoster ophtalmicus dextra. Management of this case is Acyclovir 5x800 mg for 7 days, Gabapentin 2x300 mg for 7 days, and compress with NaCl 0,9%. Patient has better outcome and patient has PHN that persist 5 months after rash dissappears. In this case, Gabapentin therapy in the acute phase can not prevent PHN but has a good outcome for reducing pain.
Management of Sporotrikosis Hendra Tarigan Sibero
JUKE Unila Vol 4, No 07 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

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The Difference in Interleukin-12 (IL-12) on Degrees of Acne Vulgaris Severity Hendra Tarigan Sibero; Eryati Darwin; Yan Wirasati; Satya Wydya Yenny; Suharmanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15797

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Introduction: Acne vulgaris (AV) is a common disorder of pilosebaceous seen mainly in adolescents. Most cases of AV present with a pleomorphic lesion array, consisting of blackheads, papules, pustules, and nodules of varying severity. Acne is one of the three most common skin disease, especially in adolescents and young adults, with an estimated prevalence of 85% (aged 12-25 years). Acne vulgaris (AV) is still a health problem in the world and Indonesia. The causes of AV are multifactorial and can lead to various complications. Aim: This study looked for the difference in interleukin-12 (IL-12) on degrees of AV severity. Materials and Method: This study was an observational analytic study with a cross-sectional approach. The research was conducted at the Diniyah Putri Islamic Boarding School, Lampung Province, Indonesia, in August 2020. The independent variable in this study was the AV degree, while the dependent variable was the IL-8 level. The sampling method in this study was consecutive sampling, as many as 63 AV patients. The research material is serum from venous blood. Examination of interleukin-8 levels using the ELISA method. Data analysis was univariate to find the mean and standard deviation of IL-8 levels, as well as the frequency distribution to determine the degree of AV. While the bivariate analysis was to determine the difference in the mean of IL-8 levels in AV patients. Results: The mean age of the respondents was 15.49 ± 1.07 years, the mean IL-12 level was 48.22 ± 15.62 and most of the AV degrees were in a severe category as much as 61.9%. Conclusion: Statistically there is no difference in the mean IL-12 levels in moderate and severe AV patients, but IL-12 levels are higher at severe AV degrees than moderate AV degrees.
The Difference in Interleukin-8 (IL-8) on Degrees of Acne Vulgaris Severity Hendra Tarigan Sibero; Eryati Darwin; Yan Wirasati; Satya Wydya Yenny; Suharmanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15798

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Background: Acne vulgaris (AV) is a follicular disease that occurs most often and affects the area containing sebaceous gland follicles, including the face, back, and body. This is a multifactorial condition. The prevalence of acne vulgaris (AV) is still high both in the world and in Indonesia. As many as 80% of AV is found at the age of 11-30 years and almost 100% in adolescents. Various factors can trigger the onset of AV which can lead to severe complications. Aim: This study looked for the difference in interleukin-8 (IL-8) on degrees of AV severity. Materials and method: This study was an observational analytic study with a crosssectional approach. The research was conducted at the Diniyah Putri Islamic Boarding School, Lampung Province, Indonesia, in August 2020. The independent variable in this study was the AV degree, while the dependent variable was the IL-8 level. The sampling method in this study was consecutive sampling, as many as 63 AV patients. The research material is serum from venous blood. Examination of interleukin-8 levels using the ELISA method. Data analysis was univariate to find the mean and standard deviation of IL-8 levels, as well as the frequency distribution to determine the degree of AV. While the bivariate analysis was to determine the difference in the mean of IL-8 levels in AV patients. Results: The mean of IL-8 levels in AV patients was 38.53. Most of the AV patients are in a severe category. Further analysis found no difference in the mean of IL-8 levels between moderate and severe AV degrees. Conclusion: There was no difference in the mean of IL-8 levels in moderate and severe AV patients, but the IL-8 levels at severe AV degrees were higher than moderate AV degrees.
Hubungan Antara Kadar Besi Darah dan Keparahan Vitiligo di RSUP Dr. Mohammad Hoesin Palembang Hendra Tarigan Sibero
JUKE Unila Vol 3, No 02 (2013)
Publisher : Fakultas Kedokteran Universitas Lampung

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Management of Infantil Hemangioma Fifa Argentina; Hendra Tarigan Sibero
JUKE Unila Vol 4, No 07 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

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PREVENTION AND EARLY DETECTION OF CONDYLOMA ACUMINATA IN HUMAN IMMUNODEFICIENCY VIRUS/ACQUIRED IMMUNODEFICIENCY SYNDROME Dwi Indria Anggraini; Hendra Tarigan Sibero; Muhammad Yusran; Ahmad Fauzi
Jambura Journal of Health Sciences and Research Vol 3, No 2 (2021): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v3i2.9922

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Abstract Human Immunodeficiency Virus infection/Acquired Immunodeficiency Syndrome in Indonesia continues to increase. HIV is a sexually transmitted infection that is often accompanied by condyloma acuminata or genital warts. The incidence of condyloma acuminata in HIV/AIDS patients is reported to vary from 10 to 30% and is associated with low CD4+ levels or at an advanced stage of HIV/AIDS. Condyloma acuminata is caused by the Human Papilloma virus which can develop into malignancy. The purpose of this activity were to increase knowledge about the disease, risk factors, and efforts to prevent condyloma acuminata, as well as to conduct early detection of condyloma acuminate disease in HIV/AIDS patients. The service was carried out through direct education to HIV/AIDS patients who went to the VCT polyclinic at dr. H. Abdul Moeloek. Early detection was done by screening new cases of HIV/AIDS patients. This activity was held for three months and was attended by 112 participants. The results of the activity showed that education could increase the knowledge about the disease, risk factors, and efforts to prevent condyloma acuminata and found 14.3% of condyloma acuminata diseases in the screening program for early detection of disease. The continuity of education and screening program for condyloma
Vitiligo Rika Lukas; Hendra Tarigan Sibero
Jurnal Kedokteran Universitas Lampung Vol 3, No 2 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i2.2523

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Vitiligo merupakan penyakit kulit dan membran mukosa kronis akibat destruksi melanosit, dengan karakteristik makula depigmentasi, mempunyai faktor predisposisi multifaktorial dan faktor pencetus seperti trauma, terbakar matahari, stres, dan penyakit sistemik. Penyebab pasti penyakit ini belum diketahui, tetapi terdapat beberapa teori yang menjelaskan tentang hilangnya melanosit epidermal pada vitiligo. Teori patofisiologi vitiligo yang paling berperan antara lain mekanisme autoimun, sitotoksik, biokimia, oksidan-antioksidan, neural, dan virus. Manifestasi klinis berupa makula amelanotik berwarna putih susu atau seperti kapur, biasanya berbatas tegas dan tepi dapat berlekuk. Klasifikasi vitiligo antara lain segmental, akrofasial, generalisata, dan universal, atau berdasarkan pola daerah yang terkena yaitu jenis fokal, campuran, dan mukosa. Penyakit endokrinopati yang sering ditemukan pada pasien vitiligo antara lain disfungsi tiroid, penyakit hipertiroid lain (penyakit Grave) atau hipotiroid (tiroiditis Hashimoto). Pemeriksaan laboratorik yang membantu dalam membangun diagnosis vitiligo, antara lain kadar thyroid stimulating hormone, anti-nuclear antibody, dan darah lengkap. Pada pemeriksaan histologi tidak ditemukan melanosit pada lesi kulit. Pengobatan berupa tabir surya, kortikosteroid topikal, imunumodulator topikal, kalsipotriol topikal, pseudokatalase, kortikosteroid sistemik, PUVA, NBUVB, laser excimer, bioskin, laser helium neon, khellin, L-fenilalanin, antioksidan, depigmentasi, autologous thin thiersch grafting, suction blister grafts, transplantasi kultur melanosit autologous, kamuflase, TNF-α, dan imunosupresan sistemik. Kata kunci: etiologi, pengobatan, vitiligo
Prevalensi dan Gambaran Epidemiologi Akne Vulgaris di Provinsi Lampung Hendra Tarigan Sibero; Ahmad Sirajudin; Dwi Indria Anggraini
Jurnal Kedokteran Universitas Lampung Vol 3, No 2 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i2.2519

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Akne vulgaris (AV) adalah penyakit kulit kronis yang multifaktorialditandai adanya peradangan pada unit pilosebasea seperti komedo, papul, pustul, nodus dan kista dengan predileksi di wajah, leher, bahu, dada, punggung dan lengan atas. Akne vulgaris terjadi pada 85% orang dewasa muda berusia 12–25 tahun. Insidensi akne vulgaris di kawasan Asia Tenggara terdapat 40-80% kasus sedangkan menurut catatan dari dermatologi kosmetika Indonesia terus terjadi peningkatan yaitu 60% penderita akne vulgaris pada tahun 2006, 80% pada tahun 2007 dan mencapai 90% pada tahun 2009.Etiologi akne vugaris belum diketahui secara pasti, diperkirakanproduksi sebum yang meningkat, hiperkeratinisasi folikel rambut, koloni bakteri Propionibacterium acnes (P. acnes) dan inflamasi. Patogenesis akne vulgaris ini diperkirakan berhubungan dengan beberapa faktor pemicu seperti faktor makanan, kosmetik, dan stress psikologis. Gambaran klinis AV ditandai dengan lesi klinis yang beragam yang letaknya terutama berada di wajah, punggung, dada dan bahu. Lesi dapat bersifat non-inflamasi maupun inflamasi. Lesi non-inflamasi berupa komedo, baik terbuka (blackhead) atau tertutup (whitehead). Lesi inflamasi berupa papul, pustul, nodul dan kista. Data penelitian mengenai akne vulgaris ini untuk daerah Lampung masih terbatas. Oleh karena itu, artikel ini bertujuan untuk mengetahui bagaimana gambaran epidemiologi dan data prevalensi akne vulgaris di Provinsi Lampung.Kata Kunci:Akne Vulgaris, Epidemiologi, Prevalensi
Polusi Udara dan Permasalahan terhadap Kulit Marcella Dena Fernanda; Hendra Tarigan Sibero; Hanna Mutiara
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.590

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Pollution has been shown to increasingly play a role in several common ailments, and the effects on the skin are no exception. Indoor and outdoor pollutants are widely distributed in urban and rural environments. WHO defines air pollution as contamination of the outdoor (ambient) and indoor (household) environment by any chemical, physical or biological agent that alters the natural characteristics of the atmosphere. Inhaled or ingested pollutants can be distributed throughout the body through the systemic circulation, making the exposed air a target for contaminants in the superficial and deep layers of the skin. The mechanisms by which pollutants may interact with human skin may differ based on each agent and its specific characteristics. Basic and clinical studies have provided growing evidence of the interaction of pollutants with the skin. Pollutants can activate skin metabolic and inflammatory pathways and induce oxidative stress by lowering antioxidant levels in particular. The skin is also a target for another known source of oxidative stress, namely UV radiation. The interaction of pollutants with UV light or the human skin microbiota requires further clinical investigation to evaluate their specific impact on skin health. Both outdoor and indoor pollution were found to increase signs of skin aging such as facial lentigines and wrinkles. Living in a polluted environment can also reduce skin moisture, increase the rate of sebum excretion and possibly worsen symptoms of chronic inflammatory skin diseases in both children and adults. Home location, type of work and diet all lead to internal and external exposure to a variety of pollutants, with clinical consequences that can accumulate or synergize. Pollutants are only one component of exposure which means that both internal and external factors must be considered when establishing pollution protection measures, which necessitates the development of standard methods for their evaluation. This literature review provides an overview of how pollutants affect the health of the skin.