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All Journal Jurnal Respirologi Indonesia Jurnal Pacta Sunt Servanda
Lestari, Nastiti
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Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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Effect of MgSO4 Administration on The Incidence of Acute Kidney Injury and Renal Function in Lung Cancer Patients Receiving Cisplatin Chemotherapy Lestari, Nastiti; Setiadji, Ana Rima; Suseno, Aryo
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.843

Abstract

Background: Platinum-based chemotherapy is the most common lung cancer therapy currently performed with satisfactory results, but the use of platinum-based chemotherapy, such as cisplatin, can cause cisplatin-induced nephrotoxicity (CIN). MgSO4 is a substance that has been studied and is known to have a protective effect on the kidneys. This study aims to determine the effect of MgSO4 administration on the incidence of CIN in lung cancer chemotherapy patients receiving cisplatin chemotherapy. Methods: This was a quasi-experimental study with a pre-test and post-test control group design. The study group received intravenous MgSO4 20 mEq, and the control group received standard therapy without MgSO4. The incidence of CIN was assessed based on the incidence of acute kidney injury (AKI) and renal function measured by the estimated glomerulus filtration rate (eGFR). Results: The incidence of AKI in the treatment group was 6.67%, whereas the control group had no incidence of AKI (P=0.32). Renal function (eGFR) showed no significant difference between the treatment and control groups (P=0.86), although both groups exhibited improved renal function post-chemotherapy. Conclusion: MgSO4 administration does not affect the incidence of AKI and renal function of lung cancer patients receiving cisplatin chemotherapy.
TINJAUAN YURIDIS MEKANISME RESTRUKTURISASI PEMBIAYAAN LAYANAN FINTECH PEER TO PEER LENDING BERDASARKAN POJK NO. 10/POJK.05/2022 TENTANG LAYANAN PENDANAAN BERSAMA BERBASIS TEKNOLOGI INFORMASI Lestari, Nastiti; Dantes, Komang Febrinayanti; Hadi, I Gusti Ayu Apsari
Jurnal Pacta Sunt Servanda Vol. 7 No. 1 (2026): Maret, Jurnal Pacta Sunt Servanda
Publisher : Universitas Pendidikan Ganesha

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Penelitian ini membahas mekanisme restrukturisasi pembiayaan layanan Fintech Peer to Peer (P2P) Lending berdasarkan POJK No. 10/POJK.05/2022 sebagai peraturan utama pelaksanaan layanan pendanaan berbasis teknologi informasi. Hasil penelitian menunjukkan bahwa POJK tidak memuat regulasi eksplisit mengenai restrukturisasi pembiayaan, tetapi hanya menegaskan kewajiban penyelenggara terkait transparansi, perlindungan konsumen, penagihan etis, dan penyampaian peringatan dalam kondisi wanprestasi. Tidak adanya norma khusus untuk restrukturisasi menciptakan ambiguitas dalam kewajiban para pihak, potensi ketidakseimbangan dalam posisi tawar dan peluang multi-interpretasi dalam penyelesaian pembiayaan yang bermasalah. Penerapan kebijakan restrukturisasi di lapangan masih bersifat internal dan berbeda antar platform, sehingga efektivitasnya dalam mencegah gagal bayar dan praktik penagihan yang berlebihan tidak optimal. Analisis yuridis menunjukkan bahwa POJK ini pada dasarnya konsisten dengan prinsip-prinsip hukum perjanjian dan perlindungan konsumen, namun masih ada kesenjangan teknis yang memerlukan harmonisasi dengan UU Perlindungan Konsumen, UU Perlindungan Data Pribadi, dan ketentuan umum KUHPerdata. Studi ini merekomendasikan pentingnya standar pembiayaan restrukturisasi dalam regulasi OJK, penguatan pengawasan, dan integrasi norma-norma lintas regulasi untuk meningkatkan kepastian hukum dan perlindungan bagi peminjam dalam ekosistem Fintech P2P Lending.
Co-Authors Hadi, I Gusti Ayu Apsari Komang Febrinayanti Dantes Setiadji, Ana Rima Suseno, Aryo