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All Journal Jurnal Ilmu Kedokteran dan Kesehatan Indonesia International Journal of Health Science
Juspeni Kartika
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The Use of Vitamin D in Heart Failure Management: A Literature Review Ratu Bertha Sofiani; Novita Carolia; Wiwi Febriani; Juspeni Kartika
International Journal Of Health Science Vol. 5 No. 3 (2025): November : International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v5i3.6152

Abstract

Heart failure is a clinical syndrome characterized by structural or functional cardiac dysfunction that leads to hemodynamic disturbances and increased morbidity and mortality. Vitamin D, a prohormone with a vital role in metabolism, is known to exert cardioprotective effects through anti-inflammatory and anti-fibrotic mechanisms, modulation of calcium homeostasis, and inhibition of the renin–angiotensin–aldosterone system. Vitamin D deficiency has been shown to be highly prevalent among patients with heart failure and is correlated with poorer clinical outcomes. Numerous preclinical studies support the protective role of vitamin D against ventricular remodeling and myocardial hypertrophy; however, clinical trials in humans have yielded inconsistent and often contradictory findings regarding its effects on systolic function, surrogate parameters, and primary outcomes such as mortality and hospitalization. Consequently, vitamin D supplementation cannot yet be recommended as a standard therapy for heart failure, except in patients with confirmed deficiency. Further research with robust methodologies and stratified populations remains essential to elucidate its potential clinical benefits.
Evaluasi Pengelolaan Obat Antibiotik di Puskesmas dalam Mendukung Program Pengendalian Resistensi Antimikroba Aisyah Qinthara Nabila Putri; Rasmi Zakiah Oktarlina; Ayu Tiara Fitri; Juspeni Kartika
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 6 No. 1 (2026): Maret : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v6i1.9537

Abstract

Antimicrobial resistance (AMR) represents a serious global health threat caused by the irrational use of antibiotics. In Indonesia, this issue has become more complex due to the high rate of antibiotic purchases without prescriptions and weak distribution control. This study aims to evaluate the effectiveness of antibiotic management in community health facilities, particularly Puskesmas, and to identify factors influencing antibiotic use practices in support of the national antimicrobial resistance control program. A qualitative method with a literature study approach was used, reviewing national and international scientific sources, including WHO reports, the Indonesian Ministry of Health, and the National Action Plan for Antimicrobial Resistance Control (RAN-PRA) 2020–2024. The findings show that approximately 41% of antibiotics are still obtained without prescriptions, and 70.75% of pharmacies in Indonesia continue to sell antibiotics freely. Both public and healthcare workers’ awareness of AMR remains low, as antibiotics are often misused for viral infections. Although national policies such as RAN-PRA adopt a One Health approach, their implementation still faces challenges, including limited resources, weak monitoring, and regional disparities. Puskesmas plays a strategic role in education, supervision, and reporting on antibiotic use but requires capacity strengthening and intersectoral collaboration. This study concludes that AMR control demands synergy among government, medical professionals, academics, and the public through enhanced education, stricter antibiotic distribution control, and evidence-based policymaking. Continuous efforts are essential to preserve antibiotic effectiveness and strengthen Indonesia’s national health resilience against global antimicrobial resistance threats.
Co-Authors Aisyah Qinthara Nabila Putri Ayu Tiara Fitri Novita Carolia Rasmi Zakiah Oktarlina Ratu Bertha Sofiani Wiwi Febriani