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All Journal The Indonesian Biomedical Journal
Meita Hendrianingtyas
Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Soedarto, Semarang 50275
Biochemistry, Genetics & Molecular Biology Public Health

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Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major Patients Sabar Widodo; Nyoman Suci Widyastiti; Edward Kurnia Setiawan Limijadi; Meita Hendrianingtyas; Dwi Retnoningrum; Ariosta Ariosta; Yetty Movieta Nency
The Indonesian Biomedical Journal Vol 17, No 4 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i4.3706

Abstract

BACKGROUND: Thalassemia patients with repeated transfusions (multi-transfusion) are often at risk of experiencing early osteoporosis. Several studies have demonstrated that osteoporosis in these individuals was associated with altered bone remodeling, characterized by decreased insulin-like growth factor-1 (IGF-1) and serum calcium ions, as well as increased serum β-Cross Laps (β-CTx) levels. Despite the prevalence of this condition, there is limited literature on the relationship between IGF-1 levels and calcium ions with β-CTx. Therefore, this study was conducted to examine the relationship between IGF-1 and calcium ions levels with serum β-CTx in multi-transfused β-thalassemia major patients.METHODS: A cross sectional study involved 29 thalassemia patients with multiple transfusions, aged 2-18 years, that were selected from the electronic medical records. Calcium ion levels were examined using ion selective electrode method. Subsequently, IGF-1 and serum β-CTx levels were examined by enzyme-linked immunosorbent assay (ELISA), and the data were analyzed using the Pearson correlation test.RESULTS: The results showed that the mean serum IGF-1 levels, calcium ion, and β-CTx were 20.11±20.763 ng/mL, 1.26±0.07 mmol/L, and 9330.40±1696.76 ng/mL, respectively. Statistical analysis showed a significant relationship between the levels of IGF-1 (r=-0.573; p=0.001) and calcium ion (r=-0.373; p=0.046) with serum β-CTx. A moderate negative relationship was found between IGF-1 levels and β-CTx, while calcium ion levels and β-CTx showed a weak negative relationship.CONCLUSION: A moderate negative correlation between IGF-1 and serum β-CTx, and a weak negative correlation between calcium ion and serum β-CTx suggest that IGF-1 and calcium ions may serve as potential indicators of bone turnover and osteoporosis risk in multi-transfused β-thalassemia major patients, underscoring their potential role in routine clinical evaluations.KEYWORDS: miR-200a expression, NO level, early-onset preeclampsia, late-onset preeclampsia
Bioscrew of Green Mussel (Perna viridis) Shells-derived Hydroxyapatite, Polylactic Acid and Polycaprolactone Increases Procollagen 1 Intact N-Terminal Propeptide and Alkaline Phosphatase in Rabbit Model with Bone Defect Kartika Dwi Aprisia; Eriawan Agung Nugroho; Meita Hendrianingtyas; Robin Novriansyah; Yora Nindita; Kevin Christian Tjandra; Danendra Rakha Putra Respati; Fitri Mutmainnah; Ferry Sandra
The Indonesian Biomedical Journal Vol 17, No 6 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i6.3795

Abstract

BACKGROUND: Hydroxyapatite (HA) is essential for bone regeneration and healing. Green mussel (Perna viridis) shell is a potential choice for preparing HA because they are abundant, widely available, have a smaller particle size, and have a higher HA content. Rather than using HA in powder or granule form, bioscrew has been fabricated as a composite of green mussel shell-derived HA, polylactid acid and polycaprolactone. However, its dynamic bone healing process has not been clearly disclosed, therefore Procollagen 1 Intact N-Terminal Propeptide (P1NP) and bone Alkaline Phosphatase (ALP) were investigated.METHODS: Male New Zealand white rabbits (Oryctolagus cuniculus) were used as animal model. The rabbits were anesthetized and prepared for surgery. A standardized defect was created in the metaphyseal region. For the treatment group, the defect was filled with a bioscrew implant, whereas the control group did not receive any implant. At week-2, -4 and -6 post-surgery, about 3 mL of blood was collected from rabbits' marginal ear vein to collect blood serum. The serum was used to quantify P1NP and ALP levels using Enzyme-linked Immunosorbent Assay (ELISA). Data of P1NP and ALP levels were then statistical analyzed.RESULTS: P1NP level of the treatment group was significantly (p<0.05) higher than the one of control group since the first monitor, at week-2. At the next monitor (week 4 and 6), P1NP levels of the treatment group were also significantly (p<0.05) higher than the ones of control group. In accordance with the P1NP results, the ALP level of the treatment group was significantly (p<0.05) higher than the one of control group.CONCLUSION: Since bioscrew of green mussel shell-derived HA, PCL and PLA could increase the PINP associated early matrix synthesis, and ALP associated with later-stage mineralization, it can be concluded that bioscrew of green mussel shell-derived HA, PCL and PLA can be a promising material to promote bone repair.KEYWORDS: bone, HA, green mussel, bioscrew, P1NP, ALP, PCL, PLA
Co-Authors Ariosta Ariosta Danendra Rakha Putra Respati Dwi Retnoningrum Edward Kurnia Setiawan Limijadi Eriawan Agung Nugroho Ferry Sandra Fitri Mutmainnah Kartika Dwi Aprisia Kevin Christian Tjandra Nyoman Suci Widyastiti Robin Novriansyah Sabar Widodo Yetty Movieta Nency Yora Nindita