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All Journal Indonesian Health Issue Journal of Innovative and Creativity
Ihsan Hakim Haviana
Universitas Muhammadiyah Bandung
Dentistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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The Role of Goblet Cells and Cilia in Respiratory Tract Mucosal Protection: A Literature Study Ihsan Hakim Haviana
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.1967

Abstract

The human respiratory system relies on a complex defense mechanism to maintain mucosal integrity against foreign particles, pathogens, and environmental pollutants. Among its key components are goblet cells, which produce mucus to trap inhaled contaminants, and cilia, which transport this mucus toward the pharynx for expulsion. This study aims to systematically review the synergistic roles of goblet cells and cilia in respiratory mucosal defense using a Systematic Literature Review (SLR) approach. Data were collected from PubMed, ScienceDirect, Google Scholar, and ResearchGate, focusing on studies published between 2010 and 2025. The findings reveal that effective mucociliary clearance depends on the balance between mucus quality and quantity and the coordinated movement of cilia. Disruptions in this system, whether due to environmental factors such as air pollution and cigarette smoke or infections like influenza and COVID-19, can impair mucus clearance, leading to increased infection risk and exacerbation of chronic respiratory diseases. Furthermore, maintaining the functionality of the mucociliary system is critical for preventing and managing respiratory disorders. Pharmacological interventions, including mucolytics, bronchodilators, and hypertonic saline, as well as the development of molecular therapies targeting mucus regulation, are promising strategies to support mucociliary function. This review emphasizes the importance of understanding goblet cell–cilia synergy in developing effective preventive and therapeutic approaches for respiratory health. Future research should focus on optimizing interventions that preserve mucociliary system function to improve patient outcomes and quality of life in respiratory care.Keywords: First keyword, second keyword, third keyword, forth keyword, fifth keyword
Integration of ISO/IEC 17025:2017 and ISO 35001:2019 into the Quality Management and Biosafety System of Clinical Microbiology Laboratories Ihsan Hakim Haviana; Dwintha Lestari; Alfi Fitriyani; Evan Haviana
Indonesian Health Issue Vol. 5 No. 2 (2026): AUGUST
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/inhis.v5i2.135

Abstract

Background: Clinical microbiology laboratories play a strategic role in healthcare systems, particularly in infectious disease diagnosis, infection control, and outbreak surveillance. However, their operations pose high biological risks, requiring management systems that ensure both test quality and biosafety. Purpose: This study aims to analyze the integration of ISO/IEC 17025:2017, which focuses on testing and calibration laboratory competence, and ISO 35001:2019, which governs biorisk management, as a model for strengthening quality and safety systems in clinical microbiology laboratories. Methods: A Systematic Literature Review (SLR) was conducted following PRISMA guidelines, covering 107 articles from Google Scholar, Scopus, PubMed, and Semantic Scholar. After screening, 17 relevant studies were thematically and bibliometrically analyzed. Results: The results revealed that integrating ISO/IEC 17025 and ISO 35001 improved test validity, increased audit efficiency by 30%, and reduced laboratory incidents by 40%. Major challenges in developing countries include limited human resources, fragmented regulations, and low levels of digitalization. Conclusion: The study concludes that integrating these standards establishes a risk-based management system that is adaptive and oriented toward continuous improvement. Cross-sectoral strategies based on the One Health Biosafety Framework are recommended to strengthen national policies and develop resilient, safe, and internationally competitive clinical laboratory systems.
Co-Authors Alfi Fitriyani Dwintha Lestari Evan Haviana