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Salsa Della Ananta Putri
Universitas Aisyah Pringsewu
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Analisis Bahan Kimia Obat Pada Jamu Asam Urat Yang Beredar Di Kota Metro Dengan Metode U-Hplc Salsa Della Ananta Putri; Vicko Suswidiantoro; Iga Mayola Pisacha; Mida Pratiwi
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.3375

Abstract

Penggunaan Bahan Kimia Obat (BKO) menimbulkan keresahan di masyarakat terutama karena beberapa jamu tradisional Obat tradisional termasuk jamu yang tidak boleh mengandung Bahan Kimia Obat atau senyawa yang sengaja ditambahkan dalam sediaan obat konvensional untuk meningkatkan khasiat sediaan obat tradisional. Penelitian ini dilakukan untuk menganalisis adanya kandungan natrium diklofenak pada jamu asam urat yang beredar di Kota Metro. Analisis dilakukan dengan pengujian kualitatif menggunakan pereaksi warna KMnO4 dan AgNO3, uji kuantitatif menggunakan U-HPLC terhadap lima sampel jamu yang diperoleh. Hasil penelitian secara kualitatif menunjukkan bahwa kelima sampel dengan kode A,B,C,D,E positif mengandung natrium diklofenak. Dan kadar natrium diklofenak yang diperoleh pada pengujian dengan U-HPLC didapatkan pada sampel B yaitu 0,198mg/L dan sampel D yaitu 0,2201mg/L. Dengan demikian, dapat disimpulkan bahwa sebagian jamu asam urat yang beredar di Kota Metro masih terindikasi mengandung Bahan Kimia Obat, sehingga perlu dilakukan pengawasan lebih lanjut mengenai keamanan produk jamu yang beredar. Kata kunci: Asam Urat, Bahan Kimia Obat, Jamu, U-HPLC ABSTRACT Traditional medicines, including herbal medicines, must not contain chemical drugs or compounds intentionally added to conventional medicinal preparations to increase the efficacy of traditional medicinal preparations. This study was conducted to analyze the presence of sodium diclofenac content in gout herbal medicines circulating in Metro City. The analysis was carried out by qualitative testing using KMnO4 and AgNO3 color reagent, quantitatively using U-HPLC on five herbal medicine samples obtained. The results of the qualitative study showed that the five samples with codes A, B, C, D, E were positive for containing sodium diclofenac. And the levels of sodium diclofenac obtained in the U-HPLC test were found in sample B, namely 0.198 mg/L and sample D, namely 0.2201 mg/L. Thus, it can be concluded that some gout herbal medicines circulating in Metro City are still indicated to contain chemical drugs, so further monitoring is needed regarding the safety of herbal products in circulation. Keywords: Gout, Herbal Medicine, Pharmaceutical Chemical Substances, U-HPLC
Uji Aktivitas Antibakteri Kombinasi Ekstrak Etanolik Bawang Putih (Allium sativum L.) Dan Daun Alpukat (Persea Americana Mill.) Terhadap Pertumbuhan Bakteri Escherichia coli Vicko Suswidiantoro; Mida Pratiwi; Riza Dwiningrum; Haikal Nur Islam; Eka Selviyana; Annisa Zahra; M.Syarif Alhauri; Anggun Fitria; Salsa della ananta putri
Journal of Innovative and Creativity Vol. 5 No. 3 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i3.3603

Abstract

Garlic (Allium sativum L.) and Avocado Leaves (Persea Americana M.) are plants that have antibacterial activity due to the presence of secondary metabolite compounds. The aim of this study is to determine the antibacterial activity of the combination extract of Garlic and Avocado Leaves against Escherichia coli bacteria and to identify the groups of active compounds contained in the extracts of Garlic and Avocado Leaves. Antibacterial activity testing was carried out using the disk diffusion method. Garlic and Avocado Leaves were extracted using 96% ethanol solvent through the maceration method. The formula for the combination extract of Garlic and Avocado Leaves was in the concentrations of 25%:75%, 50%:50%, and 75%:25%. Identification of secondary metabolite compounds was conducted using reagents. The results showed that the extract of Garlic at a concentration of 50%:50% has the activity to inhibit Escherichia coli bacteria with the largest inhibition zone diameter of 18.91 mm, categorized as strong. Identification of secondary metabolite compounds with garlic extract and avocado leaves tested positive for alkaloids, flavonoids, saponins, and tannins. The conclusion of this study is that the best combination of extracts is found in garlic extract and avocado leaves, with an inhibition zone diameter of 18.91 mm, which falls into the strong category. Both garlic extract and avocado leaves have a significant influence on the inhibition zone diameter produced by the combined extract.
Co-Authors Anggun Fitria Annisa Zahra Eka Selviyana Haikal Nur Islam iga mayola pisacha M.Syarif Alhauri Mida Pratiwi Riza Dwiningrum Suswidiantoro, Vicko