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All Journal Journal of Innovative and Creativity Mikroba: Jurnal Ilmu Tanaman, Sains dan Teknologi Pertanian
Tiara Nabila Putri
Universitas Adiwangsa Jambi
Agriculture, Biological Sciences & Forestry Education Languange, Linguistic, Communication & Media Mathematics Social Sciences Other

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Review: Tipe Salep, Basis Dan Metode Pembuatan Salep Elpa Giovana Zola; Milla Astari; Lilik Hevi Novisa; Tata Anggraini; Tiara Nabila Putri
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.8122

Abstract

Ointments are semisolid topical preparations designed to prolong drug contact time on the skin surface and provide protective effects against irritation, infection, and wounds. The effectiveness of an ointment is strongly influenced by the selection of an appropriate base and formulation method. This review aims to analyze various types of ointment bases, formulation techniques, and active substances used in recent studies. A total of 40 published journals were examined using keywords such as “ointment formulation,” “ointment base,” and “ointment preparation methods.” The findings show that hydrocarbon bases are the most widely used due to their stability and strong occlusive properties. Absorption bases and water-soluble bases are also commonly applied depending on the physicochemical characteristics of the active ingredient and therapeutic goals. The most frequently used preparation methods are incorporation and fusion, selected based on the heat sensitivity of the active substances. Most active ingredients reviewed were herbal extracts containing antibacterial, anti-inflammatory, antioxidant, and wound-healing properties. Overall, the compatibility between the ointment base, characteristics of the active compound, and the selected formulation method plays a crucial role in achieving stable, homogeneous, and effective preparations. This review highlights the high potential of natural-based ointments as safe and effective topical formulations. Keywords: Ointment, ointment base, ointment preparation method, ointment formulation, topical preparation, herbal extract.
Analisis Ekstrak Metanol Daun Sirsak (Annona Muricata Linn.) Terhadap Sel Kanker Prostat Tiara Nabila Putri; Ardi Mustakim
Mikroba : Jurnal Ilmu Tanaman, Sains Dan Teknologi Pertanian Vol. 2 No. 1 (2025): April : Mikroba : Jurnal Ilmu Tanaman, Sains Dan Teknologi Pertanian
Publisher : Asosiasi Riset Ilmu Tanaman Dan Hewani Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/mikroba.v2i1.255

Abstract

Soursop leaves contain active compounds annonaceous acetogenins which are known to have cytotoxic activity against cancer cells. This study aims to evaluate the effect of soursop leaf methanol extract (EMDS) on the viability and growth inhibition of PC3 prostate cancer cells. The research method used was an in vitro experiment with subjects in the form of PC3 cell lines divided into five groups, namely the cell control group, the treatment group with EMDS at concentrations of 6.25; 12.5; and 25 mg/mL, and the group given doxorubicin as a positive control. Cell viability was analyzed using the MTT assay method after incubation for 0 and 24 hours, and cell morphology was observed. Data analysis was carried out using the ANOVA test. The results showed that the EMDS group with concentrations of 6.25 and 12.5 µg/mL experienced a decrease in OD values, although statistically there was no significant difference. The concentration of 12.5 µg/mL had the highest inhibitory effect on cell viability with an OD value of 0.94. Observation of cell morphology indicates the presence of cytotoxic effects. Conclusion: methanol extract of soursop leaves has potential as an anticancer agent against PC3 prostate cancer cells, although the inhibitory effect is relatively small.
Co-Authors Ardi Mustakim Elpa Giovana Zola Lilik Hevi Novisa Milla Astari Tata Anggraini