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Fawwaz Daniswara
Universitas Bakti Tunas Husada
Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing

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Studi In Silico Penghambatan COVID-19 melalui Papain-Like Protease dan NSP10: Pendekatan AutodockTools dan Simulasi Dinamika Molekuler Saeful Amin; Muhammad Riffa Firdaus; Fawwaz Daniswara; Giri Guntara; Muhamad Hilmi Sutisna; Rangga Nugraha
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.44264

Abstract

COVID-19 merupakan tantangan global yang membutuhkan pengembangan terapi efektif. Studi ini mengeksplorasi potensi senyawa antivirus sebagai inhibitor terhadap enzim Papain-Like Protease (PLpro) dan Non-Structural Protein 10 (NSP10) SARS-CoV-2 melalui pendekatan in silico. Menggunakan perangkat lunak AutodockTools untuk molecular docking dan Discovery Studio Visualizer untuk visualisasi, penelitian ini mengevaluasi binding affinity dan stabilitas interaksi ligan-reseptor melalui simulasi dinamika molekuler. penelitian ini bertujuan untuk mengeksplorasi potensi senyawa antivirus sebagai penghambat COVID-19 melalui studi in silico yang mengombinasikan metode docking molekuler dengan simulasi dinamika molekuler untuk mengamati stabilitas interaksi pada level atomik. Metode penelitian ini menggunakan studi literatur dengan pendekatan in silico untuk mengeksplorasi penghambatan COVID-19 melalui Papain-Like Protease (PLpro) dan NSP10. Desain penelitian bersifat deskriptif, di mana kami mengumpulkan dan menganalisis data dari berbagai sumber yang relevan mengenai interaksi antara senyawa potensi dan target protein virus. Hasil menunjukkan bahwa umifenovir memiliki binding affinity terendah, menandakan potensi kuat sebagai inhibitor COVID-19. Stabilitas interaksi senyawa dengan residu asam amino kunci pada PLpro dan NSP10 mendukung prediksi aktivitas antivirus yang tinggi. Penelitian ini mengonfirmasi bahwa studi in silico dapat menjadi langkah awal yang penting untuk mengidentifikasi kandidat obat potensial dalam melawan COVID-19.
Implementasi Program Ceria Bermental Sehat untuk Meningkatkan Pemahaman Kesehatan Mental pada Siswa SDN 1 Tawangbanteng Fawwaz Daniswara; Rafly Fadillah Darusman; Ranti Nurhalifah
Jurnal Insan Pengabdian Indonesia Vol. 4 No. 3 (2026): September : Jurnal Insan Pengabdian Indonesia
Publisher : PT. ALHAFI BERKAH INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62007/jouipi.v4i3.1004

Abstract

Mental health constitutes a crucial component of children’s emotional, social, and learning development throughout the school-age period. The Ceria Bermental Sehat (CERIA) program was implemented as an effort to provide mental health education through an interactive and participatory approach for elementary school students. This activity aimed to improve students’ understanding of emotion recognition, emotion management, positive social relationships, and willingness to seek help when facing problems. The activity was conducted on August 6, 2026, at SDN 1 Tawangbanteng and involved 67 sixth-grade students. The activity consisted of a pre-test, three educational sessions entitled “Aku Mengenali Perasaanku,” “Aku Bisa Mengelola Emosiku,” and “Aku Tidak Sendirian,” interactive activities, ice breaking, mentoring in seven groups, and a post-test. Data were analyzed descriptively and using the Wilcoxon Signed-Rank Test because the difference scores between the pre-test and post-test were not normally distributed. The findings indicated a rise in the average score, from 83.73 in the pre-test to 92.84 in the post-test, representing an average improvement of 9.10 points. A total of 43 students (64.18%) experienced increased scores, 24 students (35.82%) showed no change, and no students experienced a decrease. The Wilcoxon analysis revealed a statistically meaningful difference in scores between the pre-test and post-test measurements (Z = −5.948; p < 0.001). The CERIA program was associated with improved students’ understanding of mental health following the educational activity.
Co-Authors Giri Guntara Muhamad Hilmi Sutisna Muhammad Riffa Firdaus Rafly Fadillah Darusman Rangga Nugraha Ranti Nurhalifah Saeful Amin