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All Journal Jurnal Ners Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia
Muhamad Hilmi Sutisna
Universitas Bakti Tunas Husada
Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Engineering Health Professions Medicine & Pharmacology Nursing

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Studi In Silico Penghambatan COVID-19 melalui Papain-Like Protease dan NSP10: Pendekatan AutodockTools dan Simulasi Dinamika Molekuler Saeful Amin; Muhammad Riffa Firdaus; Fawwaz Daniswara; Giri Guntara; Muhamad Hilmi Sutisna; Rangga Nugraha
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.44264

Abstract

COVID-19 merupakan tantangan global yang membutuhkan pengembangan terapi efektif. Studi ini mengeksplorasi potensi senyawa antivirus sebagai inhibitor terhadap enzim Papain-Like Protease (PLpro) dan Non-Structural Protein 10 (NSP10) SARS-CoV-2 melalui pendekatan in silico. Menggunakan perangkat lunak AutodockTools untuk molecular docking dan Discovery Studio Visualizer untuk visualisasi, penelitian ini mengevaluasi binding affinity dan stabilitas interaksi ligan-reseptor melalui simulasi dinamika molekuler. penelitian ini bertujuan untuk mengeksplorasi potensi senyawa antivirus sebagai penghambat COVID-19 melalui studi in silico yang mengombinasikan metode docking molekuler dengan simulasi dinamika molekuler untuk mengamati stabilitas interaksi pada level atomik. Metode penelitian ini menggunakan studi literatur dengan pendekatan in silico untuk mengeksplorasi penghambatan COVID-19 melalui Papain-Like Protease (PLpro) dan NSP10. Desain penelitian bersifat deskriptif, di mana kami mengumpulkan dan menganalisis data dari berbagai sumber yang relevan mengenai interaksi antara senyawa potensi dan target protein virus. Hasil menunjukkan bahwa umifenovir memiliki binding affinity terendah, menandakan potensi kuat sebagai inhibitor COVID-19. Stabilitas interaksi senyawa dengan residu asam amino kunci pada PLpro dan NSP10 mendukung prediksi aktivitas antivirus yang tinggi. Penelitian ini mengonfirmasi bahwa studi in silico dapat menjadi langkah awal yang penting untuk mengidentifikasi kandidat obat potensial dalam melawan COVID-19.
Optimalisasi Literasi Obat melalui Program Pojok Informasi Obat pada Kader di Desa Sinagar Widiya Zulvania; Lilis Tuslinah Sadikin; Depi Yulyanti; Neng Padia Amelia; Muhamad Hilmi Sutisna; Anjar Juliyana; Salsabila Cahyadiana Agustin; Eka Saraswati
Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia Vol. 5 No. 3 (2026): September : Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia
Publisher : Fakultas Teknik Universitas Maritim AMNI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58192/karunia.v5i3.5411

Abstract

Low medication literacy remains one of the factors contributing to irrational drug use in the community. This condition highlights the importance of improving community knowledge, particularly among women cadres who play a role in disseminating health information within their surroundings. This activity aimed to improve women cadres’ knowledge regarding drug classification, traditional medicines, and the DAGUSIBU principles (Get, Use, Store, and Dispose of medicines properly) through the Drug Information Corner Program. The activity was conducted with 26 women cadres in Sinagar Village using an educational method involving presentations and leaflets, complemented by discussions and question-and-answer sessions to enhance participants’ understanding. Knowledge was evaluated through pre-tests and post-tests, and the data were analyzed using the Wilcoxon Signed-Rank Test. The results showed that the mean knowledge score increased from 81.15 in the pre-test to 98.08 in the post-test, representing an increase of 20.86%. The Wilcoxon test results indicated a significant difference between the pre-test and post-test scores (p < 0.001). The Drug Information Corner Program was proven to improve women cadres’ knowledge regarding drug classification, traditional medicines, and the DAGUSIBU principles, thereby potentially supporting the improvement of medication literacy in the community.
Co-Authors Anjar Juliyana Depi Yulyanti Eka Saraswati Fawwaz Daniswara Giri Guntara Lilis Tuslinah Sadikin Muhammad Riffa Firdaus Neng Padia Amelia Rangga Nugraha Saeful Amin Salsabila Cahyadiana Agustin Widiya Zulvania