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All Journal Journal of Pharmaceutical and Sciences. Bioeksperimen
Agustien , Anthoni
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Potensi Antimikroba Ekstrak Infus Daun Pedada (Sonneratia caseolaris L) Mandeh, Sumatera Barat Jannah, Mifthahul; Nurlaili , Nurlaili; Harsachatri , Deasy Ovi; Novia, Novia; Larasati , Julia Veronika; Arfan , Alya Rahmaditya; Pangestika , Yuliandini; Habibi , Alif Rahman; Agustien , Anthoni
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1385

Abstract

The increasing emergence of antibiotic-resistant bacteria poses a serious global health threat, highlighting the need for alternative antimicrobial sources derived from natural products. Pedada mangrove (Sonneratia caseolaris L.), widely distributed in the coastal area of Mandeh, West Sumatra, has been traditionally used as a medicinal plant. This study aimed to evaluate the antimicrobial potential of leaf infusion extracts of Sonneratia caseolaris and to determine the effect of heating time variation on antimicrobial activity. Leaf infusion extracts were prepared using boiling water with heating durations of 10, 15, and 30 minutes. Antimicrobial activity was assessed against Escherichia coli, Staphylococcus aureus, and Candida albicans using the disc diffusion method. The results showed that all infusion extracts exhibited antimicrobial activity with varying inhibition levels. The optimal heating time was 10 minutes, resulting in inhibition zone diameters of 10.5 mm against E. coli, 10 mm against S. aureus, and 10 mm against C. albicans. These findings indicate that Sonneratia caseolaris leaf infusion extract has potential as a natural antimicrobial agent, with shorter heating time being more effective in preserving antimicrobial activity.
Antagonistic activity of phyllosphere fungi isolated from medicinal plants against Colletotrichum sp. causing anthracnose in chilli (Capsicum annuum L.) Puspita, Ayumi Rizci; Alamsjah, Feskaharny; Mildawati, Mildawati; Agustien , Anthoni
Bioeksperimen: Jurnal Penelitian Biologi March 2026
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v12i1.16072

Abstract

Anthracnose disease caused by the fungus Colletotrichum sp. is one of the main problems in chili cultivation (Capsicum annuum L.) and can cause significant yield losses. The intensive use of chemical pesticides in controlling this disease has a negative impact on the environment and health. This study aimed to evaluate the antagonistic potential of phyllosphere fungi isolated from five medicinal plants, namely Phaleria macrocarpa, Curcuma domestica, Kleinhovia hospita, Hibiscus rosa-sinensis, and Morus macroura, against the pathogen Colletotrichum sp. Isolation was performed from leaf surfaces, and a total of 7 phyllosphere fungal isolates were tested using a double culture method with three replicates. The results showed that all isolates were able to inhibit the growth of Colletotrichum sp. through mechanisms of competition for space and nutrients as well as antibiosis, with inhibition levels ranging from high to very high. Among the tested isolates, Trichoderma sp. exhibited the highest inhibitory activity with an inhibition percentage of 92.78%, categorized as very high. Macroscopic and microscopic characterization supported the identification of several isolates belonging to the genera Trichoderma. This study concluded that phyllosphere ungi from medicinal plants have the potential as environmentally friendly biological control agents in combating anthracnose disease in chili plants.
Co-Authors Arfan , Alya Rahmaditya Feskaharny Alamsjah Habibi , Alif Rahman Harsachatri , Deasy Ovi Larasati , Julia Veronika Mifthahul Jannah Mildawati Mildawati Novia Novia Nurlaili , Nurlaili Pangestika , Yuliandini Puspita, Ayumi Rizci