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All Journal Sasambo Journal of Pharmacy Jurnal Kesehatan Farmasi Sinteza
Azima Azima
Universitas Sulawesi Barat
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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A REVIEW ARTIKEL: POTENSI AKTIVITAS ANTIBAKTERI TANAMAN RUMPUT KNOP (Hyptis capitata Jacq) Rosnidar Sumardi; Neng Mira Atjo; Wisdayanti Wisdayanti; Anisa Dwirizky Abdullah; Auliah Rahmi Latif; Widya Luthfiyah; Ekasari Kartika Putri Wibowo; Azima Azima; Putri Ramdaniah; Nadya Pratiwi
Jurnal Kesehatan Farmasi Vol 8 No 1 (2026): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v8i1.3751

Abstract

ABSTRAK Latar Belakang: Antibiotik merupakan obat untuk mengobati infeksi yang disebabkan oleh bakteri. Pemberian antibiotik pada penderita penyakit infeksi bertujuan untuk menghambat pertumbuhan maupun membunuh bakteri penyebab penyakit, akan tetapi jika penggunaan antibiotik tidak tepat akan mengakibatkan resistensi antibiotik. Dalam upaya untuk menemukan alternatif pengobatan antibakteri yang efektif, penelitian terhadap senyawa alami dari tumbuhan telah mendapatkan perhatian yang semakin besar. Ekstrak tanaman yang kaya akan berbagai senyawa bioaktif, memiliki potensi sebagai agen antibakteri yang dapat digunakan dalam pengobatan infeksi bakteri. Tujuan: Studi ini bertujuan untuk memberikan informasi mengenai potensi antibakteri dari tanaman Rumput Knop (Hyptis capitata Jacq.). Metode: Tinjauan artikel ini dilakukan melalui studi Pustaka dari 6 artikel penelitian dengan rentang tahun publikasi 2012-2025. Hasil: Ekstrak daun, akar, dan bunga Rumput Knop (Hyptis capitata Jacq.) menunjukkan aktivtas penghambatan yang kuat terhadap bakteri Methicillin-Resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Eschericia coli, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, Propionibacterium acnes, Streptococcus sobrinus, dan Bacillus cereus. Kesimpulan: Tanaman Rumput Knop (Hyptis capitata Jacq.) memiliki potensi sebagai antibakteri.
Formulasi Dan Uji Aktivitas Antioksidan Sediaan Gel Peeling Scrub Ekstrak Etanol Daun Teh Hijau (Camellia Sinensis) Asal Malino Dengan Metode DPPH Azima Azima; Arham Febrianto; Nielma Auliah; Sri Wahyuningsih
Sasambo Journal of Pharmacy Vol. 7 No. 1 (2026): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v7i1.609

Abstract

Abstract: Free radicals originating from both internal and external factors can cause skin damage such as premature aging and inflammation. Antioxidants are compounds that can neutralize free radicals, and one natural source is green tea leaves (Camellia sinensis), which are rich in flavonoids and polyphenols. This study aimed to formulate a peeling gel scrub from ethanol extract of green tea leaves from Malino and evaluate its antioxidant activity using the DPPH method. Extraction was carried out by maceration using 96% ethanol, and the gel was formulated in three extract concentrations (1%, 3%, and 5%). Physical evaluations included organoleptic, homogeneity, pH, viscosity, spreadability, adhesion, irritation, and stability tests (cycling test). Antioxidant activity was assessed using UV-Vis spectrophotometry and expressed as ICâ‚…â‚€ values. The results showed that all formulas were physically and chemically stable and exhibited very strong antioxidant activity, with the lowest ICâ‚…â‚€ value observed in the 5% formula at 22.13 ppm. Therefore, the green tea extract peeling gel scrub has potential as a natural-based topical cosmetic product effective as an antioxidant. Keywords: Green tea, peeling gel scrub, antioxidant, DPPH, ICâ‚…â‚€
Perbandingan Metode Ekstraksi terhadap Kadar Flavonoid dan Aktivitas Antioksidan Ekstrak Etanol Daun Pulai (Alstonia scholaris) dengan Metode 2,2-difenil-1-pikrilhidrazil (DPPH) Sri Wahyuningsih; Nur Indah Sari; Hilmiati Wahid; Azima Azima
Sinteza Vol. 6 No. 1 (2026): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i1.31992

Abstract

Pulai leaves (Alstonia scholaris) are known to contain various secondary metabolites such as flavonoids, so the choice of extraction method is a factor that affects the quality and quantity of bioactive compounds produced. This study aims to compare the total flavonoid content and antioxidant activity of ethanol extracts of pulai leaves obtained through two different extraction methods, namely maceration and reflux. This study is a laboratory experimental study using 96% ethanol solvent in both extraction methods. The flavonoid content was determined quantitatively using UV-Vis spectrophotometry with quercetin as the standard. The antioxidant activity test was performed using the 2,2-diphenyl-1-picrylhydrazil (DPPH) method based on the IC50 value. The results showed that the extract obtained using the reflux method had a higher flavonoid content of 17.11±0.03 mgQE/g and an IC50 value of 7.84±0.02 ppm, while the maceration method produced a flavonoid content of 8.42±0.02 mgQE/g and an IC50 value of 12.53±0.17 ppm. As a positive control, vitamin C had an IC50 value of 5.26±0.08 ppm. Based on these results, the extraction of pulai leaves (Alstonia scholaris) using the reflux method proved to be more effective in extracting flavonoid compounds and had higher antioxidant activity compared to the maceration method.
Co-Authors Anisa Dwirizky Abdullah Arham Febrianto Auliah Rahmi Latif Ekasari Kartika Putri Wibowo Hilmiati Wahid Nadya Pratiwi Neng Mira Atjo Nielma Auliah Nur Indah Sari Putri Ramdaniah Rosnidar Sumardi Sri Wahyuningsih Sri Wahyuningsih Widya Luthfiyah Wisdayanti Wisdayanti