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All Journal Journal of Pharmaceutical and Sciences. Jurnal Etnofarmasi
Dian Nur Khofifah
UNIVERSITAS PENDIDIKAN MUHAMMADIYAH SORONG
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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PENGARUH PERBEDAAN METODE EKSTRAKSI SIRIH CINA (Peperomia pellucida L.) TERHADAP KADAR TOTAL FLAVONOID DAN ALKALOID Dian Nur Khofifah; Indah Amelia
JURNAL ETNOFARMASI Vol. 3 No. 01 (2025): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v3i01.1972

Abstract

Chinese betel has benefits as a traditional medicine to treat gout, rheumatism, and arthritis. The compounds contained in Chinese betel include flavonoids, saponins, tannins, steroids, and terpenoids which have various pharmacological activities, such as anti-inflammatory, antibacterial, diuretic, antifungal, and antiviral. This study was conducted to determine the effect of different extraction methods on the compound content and to determine the effect of these different extractions on the total levels of flavonoids and alkaloids contained in the Chinese betel plant (Peperomia pellucida L.) using three extraction methods, namely maceration, soxhletation, and reflux. The highest yield was obtained with the reflux method of 20%, then with the soxhletation method (12%) and maceration (10%). Phytochemical tests showed the presence of alkaloids, flavonoids, tannins, terpenoids, and steroids in the leaf extract, while saponins were not detected. The results of the FTIR analysis showed the presence of O-H, C=C, -C-NO2, and C-O functional groups, thus supporting the results of phytochemical screening. Determination of total flavonoid levels showed that the reflux method produced the highest levels (47.5095 mg/g), while the highest alkaloid levels were obtained from the maceration method (26.9333 mg/g).
Studi In Vivo Efek Nefroprotektif Ekstrak Etanol Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) terhadap Profil Kreatinin Serum Mencit Dian Nur Khofifah; A. M. Muslihin; Lukman Hardia
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1522

Abstract

Background: Nephrotoxicity due to the use of drugs such as gentamicin can cause kidney damage characterized by increased creatinine levels. The use of medicinal plants as nephroprotective agents is a potential alternative; one such plant is yellow rope stem (Anamirta cocculus (L.) Wight & Arn.), known to contain antioxidant compounds. Objective: This study aims to assess the nephroprotective activity of yellow rope stem ethanol extract and determine the optimal dose for reducing gentamicin-induced increases in creatinine levels in mice. Method: The study was conducted experimentally with a pre-test and post-test design using the maceration method with 70% ethanol solvent. Mice were divided into six groups, namely negative control, positive control (vitamin E), healthy control, and three treatment groups with varying extract doses. Creatinine levels were measured using the Jaffe method with a UV-Vis spectrophotometer. Results: The results showed that the yellow rope stem ethanol extract at a dose of 77 mg/kgBW was able to reduce creatinine levels significantly (p<0.05), while lower doses did not show a significant difference. Conclusion: Ethanol extract of yellow rope stems has nephroprotective activity at an optimal dose of 77 mg/kgBW, thus having the potential to be developed as a herbal agent to protect kidney function.
Co-Authors A. M. Muslihin Indah Amelia Lukman Hardia