This study aims to identify these factors in the context of health science education, particularly in the applied health sciences and maternal and child health. The study adopts a quantitative approach using a cross-sectional design. The study population includes postpartum mothers at Harapan Mulia Hospital in Bekasi (83 post-cesarean section mothers), Pondokgede District General Hospital (35 post-cesarean section mothers), and TPMB Lia Kamalia (35 normal postpartum mothers). Research instruments included structured questionnaires, observations of breastfeeding techniques, and interviews. Bivariate analysis was performed using the Chi-Square test, with a significance level of p <0.05. The results revealed that most mothers had good knowledge (62.9%), good nutrition (62.7%), were not at risk (73.3%), had a complete ANC history (66.7%), received good family support (60%), had good healthcare support (69.8%), adopted a healthy lifestyle (77.4%), practiced Early Breastfeeding Initiation (94.3%), and used correct breastfeeding techniques (85.7%). All these factors were significantly associated with breastfeeding success (p value < 0.05). Multivariate analysis using multiple logistic regression indicated that the dominant factors contributing to breastfeeding success were good breastfeeding technique (OR = 20.1; p = 0.004), Early Breastfeeding Initiation (EBI) (OR = 9.56; p = 0.045), and healthcare support (OR = 8.15; p = 0.001). This study underscores the need for comprehensive education and promotion of exclusive breastfeeding, emphasizing its significance in health science education. A holistic approach, including family-based interventions and strengthening maternal health literacy in the context of applied health sciences, is essential for enhancing breastfeeding success, particularly for mothers post-cesarean section. This research contributes to the improvement of maternal and child health services and the advancement of health science education in the context of midwifery services