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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Acta Chimica Asiana Abdimas Pedagogi: Jurnal Ilmiah Pengabdian kepada Masyarakat
Muhammad Farid
Universitas Ahmad Dahlan
Chemistry Medicine & Pharmacology

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Molecular docking study of catharanthus roseus compounds as potential ABL1 inhibitors for leukemia treatment Muhammad Farid; Shalahuddin Al Madury; Ahmad Suriyadi Muslim; Zakiyyah Qurrotul ‘Aini
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.235

Abstract

Leukemia is one type of cancer with a high mortality rate, caused by the proliferation of abnormal white blood cells that disrupt hematopoiesis function. Conventional therapies, such as chemotherapy and targeted therapy, often face challenges in the form of side effects and drug resistance. This study aims to evaluate the potential of Catharanthus roseus as a leukemia therapeutic agent through in silico. The docking process uses autodock, and ADMET prediction uses SwissADME and PKCMS. The study used the ABL1 protein (PDB ID: 4TWP) as a target with active compounds of Catharanthus roseus. The validation process of the docking method showed an RMSD value of 0.705 Å, indicating that the method used was valid. The results of the docking simulation showed that vindoline had the best affinity after native ligands with a binding energy of -8.64 kcal/mol, followed by catharanthine -6.16 kcal/mol and tryptophan -3.87 kcal/mol. ADMET prediction analysis showed that vindoline and catharanthine had promising pharmacokinetic and toxicity profiles, such as good blood-brain barrier (BBB) permeability and did not inhibit the CYP3A4 enzyme. These results indicate that vindoline and catharanthine are potential alternative leukemia treatments with high efficacy and low risk of side effects. This study provides a basis for further exploration of Catharanthus roseus in the development of effective and safe leukemia therapies.
Network Pharmacology Analysis of Black Turmeric (Curcuma caesia Roxb.) for Diabetic Nephropathy: Exploring Potential Therapeutic Targets Zakiyyah Qurrotul 'Aini; Muhammad Farid; Tri Wijayanti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.11617

Abstract

Diabetes mellitus is a non-communicable disease with a high prevalence that has the potential to cause chronic complications, such as diabetic nephropathy (ND). Diabetic nephropathy is characterized by microalbuminuria, decreased glomerular filtration rate, and the risk of end-stage renal failure. Conventional treatment with oral hypoglycemic drugs often causes side effects such as hyperkalemia and impaired heart function. This indicates the need for alternative therapies with high effectiveness, low toxicity, and affordable costs. This study explores the potential of black turmeric as a therapeutic agent for diabetic nephropathy through an in-silico approach. The active compounds of black turmeric were analyzed for their pharmacokinetics using SwissADME based on Lipinski's rules. The target proteins of the compounds were obtained through SwissTargetPrediction and compared with ND-encoding proteins from GeneCards using Venny 2.1. Specific proteins were analyzed for protein-protein interactions through STRING and visualized with pharmacological networks using Cytoscape. In-depth analysis was carried out to identify biological pathways through KEGG and molecular activity using WebGestalt. The results showed that black turmeric has 123 specific target proteins for ND, with EGFR and STAT3 as core proteins that play a role in regulating apoptosis, inflammation, and insulin sensitivity. Curcumin showed significant activity on the AGE-RAGE and FoxO pathways, which are relevant for the treatment of ND. This study provides initial insight into the potential of black turmeric as an alternative therapy for diabetic nephropathy
Peningkatan Pemahaman Anatomi Manusia pada Siswa Kelas VI SDN Tamanan melalui Media 3D dan Alat Peraga Dewi Yuniasih; Ario Tejosukmono; Rr. Wiwara Awisarita; Muhammad Farid; Azhar Alfarisy Frinces; Raihanah Arifah Ariyanti; Muhmmad Faiz Arryawan; Mohammad Tri Yogatianotak; Keysha Malika Aqila; Insani Wuri Susanti
Abdimas Pedagogi: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 2 (2026)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um050v9i22026p71-74

Abstract

Pembelajaran anatomi manusia di tingkat sekolah dasar seringkali mengalami kendala karena keterbatasan media yang digunakan. Kegiatan pengabdian mas,yarakat ini bertujuan untuk meningkatkan pemahaman siswa kelas 6 SDN Tamanan terhadap sistem rangka, otot, dan persarafan dengan memanfaatkan media 3D dan alat peraga anatomi. Kegiatan dilaksanakan pada tanggal 20 Agustus 2025 pukul 09.00–11.30 WIB oleh tim dosen dan mahasiswa Fakultas Kedokteran Universitas Ahmad Dahlan. Metode yang digunakan meliputi pretest dan posttest secara tanya jawab, serta demonstrasi menggunakan stand anatomi rangka, peraga otot ekstremitas, tulang, dan otak. Hasil kegiatan menunjukkan peningkatan pemahaman siswa yang cukup signifikan, terlihat dari partisipasi aktif dan kemampuan menjawab pertanyaan setelah intervensi. Kesimpulannya, penggunaan media anatomi 3D terbukti efektif untuk meningkatkan pemahaman konsep anatomi dasar di sekolah dasar.
Co-Authors Ahmad Suriyadi Muslim Ario Tejosukmono Azhar Alfarisy Frinces Dewi Yuniasih Insani Wuri Susanti Keysha Malika Aqila Mohammad Tri Yogatianotak Muhmmad Faiz Arryawan Raihanah Arifah Ariyanti Rr. Wiwara Awisarita Shalahuddin Al Madury Tri Wijayanti Zakiyyah Qurrotul 'Aini Zakiyyah Qurrotul ‘Aini