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Lubis , Razoki
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Uji Efektivitas Ekstrak Daun Kelor (Moringa oleifera) dalam Menurunkan Kadar Asam Urat pada Mencit (Mus Musculus) Yang Diinduksi Hati Ayam Sidauruk , Resti Novita; Novriani , Erida; Lubis , Razoki
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1328

Abstract

Background: Hyperuricemia is a metabolic disorder with an increasing prevalence and a risk of developing into gout if not properly treated. The use of allopurinol as a conventional therapy is effective in lowering uric acid levels; however, it may cause side effects, thus safer natural-based therapeutic alternatives are needed. Moringa leaves (Moringa oleifera) are known to contain bioactive compounds with potential antihyperuricemic activity. Objective: This study aimed to evaluate the effectiveness of Moringa leaf extract in reducing uric acid levels in mice (Mus Musculus) with hyperuricemia induced by chicken liver. Methods: This laboratory experimental study with a controlled group design used 30 mice divided into six groups (n = 5): normal control, negative control (5% Na-CMC), positive control (allopurinol 10 mg/kgBW), and three treatment groups receiving Moringa leaf extract at doses of 70, 140, and 280 mg/kgBW. Hyperuricemia was induced using chicken liver. Uric acid levels were measured daily for 7 days using a Multicheck Nesco® device. Data were analyzed using One-Way ANOVA followed by the Tukey Post Hoc test with a significance level of p < 0.05. Results: Chicken liver induction successfully increased uric acid levels in mice in all treatment groups (baseline levels of 3.26–3.42 mg/dL increased to 8.20–8.30 mg/dL). Moringa leaf extract showed a gradual and dose-dependent reduction in uric acid levels. The dose of 280 mg/kgBW provided the most optimal reduction effect (from 8.22 mg/dL to 3.44 mg/dL on day 7; p < 0.05), approaching the effectiveness of the positive control allopurinol (from 8.30 mg/dL to 3.52 mg/dL). Phytochemical screening confirmed the presence of active compounds such as flavonoids, alkaloids, saponins, phenols, and triterpenoids which play a role in inhibiting the xanthine oxidase enzyme. Conclusion: Moringa leaf extract effectively reduces uric acid levels in mice induced with hyperuricemia, with the dose of 280 mg/kgBW being the most optimal. Moringa leaf extract has potential to be developed as a natural-based antihyperuricemic therapeutic alternative.
Isolasi Protein dan Bakteri Asam Laktat dari Pangan Tradisional Dali Ni Horbo yang Dimodifikasi sebagai Kandidat Probiotik Natasya, Balqis; Meha , Lasminar; Lubis , Asyrun; Lubis , Razoki; Piska , Finna
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1367

Abstract

Background: Dali ni horbo is a traditional North Sumatran food made from buffalo milk that has potential as a source of protein and lactic acid bacteria (LAB). Its high nutritional content and fermentation process make it a promising candidate for functional food development with probiotic properties. Objective: This study aimed to isolate and characterize proteins and LAB from dali ni horbo produced using different treatments, namely pure buffalo milk, the addition of pineapple juice, and the addition of citrus juice. Methods: Protein isolation was carried out using the ammonium sulfate precipitation method, while LAB were isolated on MRS agar supplemented with CaCO₃. Protein characterization was performed using biuret, ninhydrin, and xanthoprotein tests. LAB characterization included Gram staining, catalase test, and bile salt tolerance test. Results: The results showed that the protein isolate obtained using pineapple as a coagulant had the highest yield (2.3321 g) compared to citrus (1.8516 g). All protein isolates tested positive for biuret, ninhydrin, and xanthoprotein, indicating the presence of peptide bonds, amino acids, and aromatic groups. A total of 18 LAB isolates were obtained, all of which were Gram-positive, rod-shaped, catalase-negative, and tolerant to bile salts. Conclusion: Dali ni horbo has strong potential as a source of protein and probiotic candidates, indicating its applicability as a functional food to support health.
Co-Authors Finna Piska Lubis , Asyrun Meha , Lasminar Natasya, Balqis Novriani , Erida Sidauruk , Resti Novita