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Formulasi Dan Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Etanol Daun Kerai Payung (Fillicium Decifiens) Terhadap Bakteri Propionibacterium acne dan Staphylococcus epidermis Gadis Minanda Fauziah Purba; Idaman Lase; Reh Malem br Karo; Razoki Lubis; Finna Piska
PRIMER (Prima Medical Journal) Vol. 8 No. 1 (2023): Edisi April
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/pmj.v8i1.3786

Sunshade (Fillicium decipiens) is a member of the Sapindaceae family, including some active antibacterial substances. To determine the antibacterial activity of Fillicium decipiens leaf ethanol extract gel against Propionibacterium acne and Staphylococcus epidermis bacteria, this study produced Fillicium decipiens leaf ethanol extract gel preparations using various extract concentrations and other formulations. Fillicium decipiens leaf extraction method by maceration using 96% ethanol. Prepare Fillicium decipiens leaf ethanol extract gel formulation using carbopol 940 base using various concentrations of Fillicium decipiens leaf ethanol extract, each 5%, 10%, and 15%. Gel preparations were tested for the physical properties of the gel, including an organoleptic test, pH test, homogeneity test, and spreadability test. As a result of organoleptic tests, the ethanol extract gel preparation of Fillicium decipiens leaves in each formula, namely F0 (clear color, extract aroma, semi-solid), F1 (greenish-brown color, extract aroma, semi-solid), F2 (greenish-brown color, extract aroma, semi-solid), F3 (greenish brown in color, parasol extract, relatively viscous), for the homogeneity test of the gel preparation formula, it was obtained entirely homogeneous. The formulation that produced the highest inhibition against Propionibacterium acne and Staphylococcus epidermis bacteria was formulation 3 (15% concentration of Fillicium decipiens leaf extract), where the inhibition zone obtained was 17.99 mm for Propionibacterium acne and 17.45 mm for Staphylococcus epidermis.

Inhibisi Enzim α-Glukosidase oleh Bacillus Megaterium ITU 9 Isolat Sumber Air Panas Sumatera Utara Piska, Finna; Ginting, Chrismis Novalinda; Harmileni, Harmileni; Fachrial, Edy
Jurnal Pharmascience Vol 11, No 1 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i1.17045

Diabetes adalah penyakit multifaktor yang insidensinya meningkat dengan pesat di negara berkembang. Diabetes mellitus (DM) tipe 2 adalah jenis diabetes yang paling umum ditemui, dimana penyakit ini erat kaitannya dengan kemajuan industri dan teknologi sehingga mempengaruhi gaya hidup seseorang. Penanggulangan penyakit ini dapat dilakukan dengan menghambat aktivitas α-glukosidase. Beberapa mikroorganisme terutama dari sumber air panas dapat dimanfaatkan sebagai penghasil senyawa inhibitor α-glukosidase. Pada penelitian sebelumnya isolat Bacillus megaterium ITU 9 merupakan isolat yang diisolasi dari sumber air panas. Pada penelitian ini diuji kemampuan isolat Bacillus megaterium ITU 9 sebagai penghasil inhibitor α-glukosidase dengan metode sumur. Daya persen inhibisi supernatan B. megaterium ITU 9 terhadap kerja enzim α-glukosidase adalah sebesar 46,67%, sedangkan daya persen inhibisi acarbose yaitu 70%. Dalam hal ini B. megaterium ITU 9 termofilik memiliki daya inhibisi terhadap enzim α-glukosidase. Kata Kunci: Bakteri Termofilik, Inhibitor, Akarbose, Metode Sumur, Persen Inhibisi Diabetes is a multifactorial disease whose incidence is increasing rapidly in developing countries. Diabetes mellitus (DM) type 2 is the most common type of diabetes, where this disease is closely related to industrial and technological advances, thus affecting a person's lifestyle. This disease can be controlled by inhibiting α-glucosidase activity. Several microorganisms, especially from hot springs, can be used to produce α-glucosidase inhibitor compounds. In previous research, the Bacillus megaterium ITU 9 isolate was an isolate isolated from hot springs. In this study, the ability of the Bacillus megaterium ITU 9 isolate to produce α-glucosidase inhibitors was tested using the well method. The percent inhibition power of B. megaterium ITU 9 supernatant on the action of the α-glucosidase enzyme was 46.67%, while the percent inhibition power of acarbose was 70%. In this case, the thermophilic B. megaterium ITU 9 has inhibitory power against the α-glucosidase enzyme.

Uji Toksisitas Subkronik Ekstrak Etanol Biji Ketumbar (Coriandrum Sativum L.) Terhadap Fungsi Jantung Dan Paru-Paru Pada Tikus Jantan (Rattus Norvegicu.) Jennie Try Varian Laoli; Nerly Juli Pranita Simanjuntak; Finna Piska
An-Najat Vol. 2 No. 3 (2024): AGUSTUS - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i3.1530

Coriander seed plant (Coriandrum sativum.) Apiaceae family As an alternative medicine to reduce various risk factors for heart disease including LDL cholesterol levels and high blood pressure, characterization and preparation of ethanol extract of coriander seeds (EEBK) using the maceration method was the first step in this research, followed by with subchronic toxicity testing. Subchronic toxicity testing used male rats (Rattus Norvegicu.) each of which was divided into 5 groups, namely control CMC Na 0.5%, EEBK doses of 100, 200, 400 and 500 mg/kg bw. In the subchronic toxicity test, the parameters observed included toxic symptoms, changes in body weight, death, as well as microscopic and macroscopic examination of organs, including hematological examination. This observation lasted for 28 days. Subchronic test data were analyzed using the Statistical Product and Service Solution with two-way ANOVA, followed by the Tukey and Kruskal-Wallis post-hoc test. Findings from the subchronic toxicity study indicated that EEBK did not have a toxic effect, because there was no significant difference in changes relative organ weight, body weight, number of mouse deaths, toxic symptoms, organ macroscopic, and hematological values were compared with the control group (P > 0.05).

Karakteristik Fisik Sabun Organik Berbasis Minyak Jelantah dan Ekstrak Buah Pinang (Areca cathecu L) Dengan Biosurfaktan Buah Lerak (Sapindus rarak DC) Agustina, Nur Ariyani; Finna Piska
Agroprimatech Vol. 7 No. 2 (2023): Agroprimatech
Publisher : Prodi Agroteknologi Fakultas Agro Teknologi Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/agroprimatech.v7i1.4416

Used cooking oil waste is very dangerous for the environment if it is not used or processed properly. Used cooking oil can be used as a raw material for used cooking oil mixed with areca nut. Areca nut contains substances that are beneficial for skin health such as tannins, alkaloids, and flavonoids. In improving the quality of this organic soap, biosurfactants from lerak fruit can also be added as a mixture of organic soaps. This research aims to develop an organic soap based on used cooking oil and areca nut extract with lerak fruit biosurfactant to improve skin health and reduce negative environmental impacts. The research method used a 2 factorial completely randomized design with factor 1, namely areca nut extract (P) which consisted of 3 levels: 4 mL, 6 mL, and 8 mL. Factor 2 was lerak fruit extract (L) which consisted of 3 levels, namely 35%, 45%, and 55%. The research results obtained that activated charcoal and zeolite are very effective in absorbing impurities contained in used cooking oil. This can be seen from the clear golden yellow color of the used cooking oil that has been purified. In organoleptic testing, it was found to have a dark red color, a characteristic odor and a thick texture. The results showed that the addition of areca nut extract and lerak fruit extract had a very significant effect on the results of variance where P<0.05 for all test parameters. The best treatment was found in P3L3 where 8 mL of areca nut extract and 55% of lerak fruit extract resulted in a pH of 8.89, foam height of 10.4 cm, foam stability of 97%, water content of 34.97%. The results of all treatments show that they have fulfilled SNI 06-4085-1996 which can be used as organic liquid body soap. Keyword: lerak, organic soap, used cooking oil, areca nut, biosurfactant

Antioxidant test of crude extract of secondary metabolites from Fusarium sp. isolate of rizosphere of cat’s whisker Piska, Finna; Zega, Sati Angriani; Hutauruk, Rico Halim; Septia, Evianti Dwi; Meutia, Rena
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5344

Antioxidants are compounds needed in the prevention and therapy of diseases such as diabetes mellitus, cancer and premature aging. Over time, secondary metabolite compounds as antioxidants can be obtained from microbes, namely those originating from the endophyte and rhizosphere of plants. Based on previous research, secondary metabolites that act as antioxidants are flavonoids and phenolics, with phenolic compounds and flavonoids can bind free radicals through hydroxyl groups present in their aromatic rings. Microbes that live on medicinal plants will have similarities in producing secondary metabolites which can also be used as medicine. Fusarium sp. Laboratorium Basic Science UNPRI (LBSU) isolate is an isolate isolated from the rhizosphere of the cat's whisker plant (Orthosiphon stamineus). The cat's whisker plant is known to be an antioxidant. This study aims to test the antioxidant crude extract of secondary metabolites from Fusarium sp. LBSU. The method for isolating secondary metabolites is by liquid fermentation, then extracted using ethyl acetate and tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The antioxidant test results were obtained from the DPPH radical inhibition value by Ethyl acetate Extract of Fusarium sp. LBSU (EEF) is 44%, while Vitamin C is 88%. Thus, the ability to capture DPPH free radicals by EEF is 44%, weaker than Vitamin C.

Antibacterial test of secondary metabolites of Rhizosphere bacterial isolates of cat whisker against Escherichia coli and Staphylococcus aureus Septia, Evianti Dwi; Hutauruk, Rico Halim; Razoki, Razoki; Piska, Finna
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5544

The rhizosphere is the zone between the root surface and soil. Rhizosphere bacteria can produce metabolites that are antibacterial because they produce phytotherapeutic compounds that have the same properties as those produced by the plant. The purpose of this study was to isolate secondary metabolite compounds from the rhizosphere bacteria of cats’ whisker plants (Orthosiphon stamineus) as antibacterial agents against Escherichia coli and Staphylococcus aureus. This study began with the isolation of rhizosphere bacteria, purification, bacterial characterization, bacterial fermentation, and antibacterial tests. The results of the isolation of Orthosiphon stamineus rhizosphere bacteria obtained as many as six isolates, with each isolate coded as RKK-1, RKK-2, RKK-3, RKK-4, RKK-5, and RKK-6. The results showed that RKK-5 had an inhibition zone against Escherichia coli with a diameter of 8.5 mm. Based on these results, it can be concluded that RKK-5 has a moderate response to Escherichia coli.

Rasionalitas Penggunaan Obat Hiperurisemia dan Gout Artritis di Poli Penyakit dalam RSU Royal Prima Marelan Olivia Happy Novita; Razoki Lubis; Finna Piska
Vitamin : Jurnal ilmu Kesehatan Umum Vol. 3 No. 2 (2025): April : Jurnal ilmu Kesehatan Umum
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/vitamin.v3i2.1307

The use of drugs for hyperuricemia and gout arthritis is given for conditions that cause higher purine metabolism in the body. This study was conducted at RSU Royal Prima Marelan to determine the pattern of drug use for hyperuricemia and gout arthritis due to inflammation caused by uric acid deposits in the joints. Data collection in this study was carried out retrospectively by collecting medical records of patients with hyperuricemia and gout arthritis. The descriptive method used in this study was a cross-sectional plan. Qualitative descriptive analysis was applied to the data. Tables or narratives were used to present the data in this study. The results showed that 30 patients out of 50 were male and 20 were female. The results of the evaluation of the rationality of drug use for hyperuricemia and gout arthritis showed that patients who were given several versions of drugs with the xanthine oxidase inhibitor group 64% were allopurinol with patients with the most appropriate indications, the right patient, and the right dose of 96%.

Karakteristik Fisik Sabun Organik Berbasis Minyak Jelantah dan Ekstrak Buah Pinang (Areca cathecu L) Dengan Biosurfaktan Buah Lerak (Sapindus rarak DC) Agustina, Nur Ariyani; Piska, Finna
Agroprimatech Vol. 7 No. 2 (2023): Agroprimatech
Publisher : Prodi Agroteknologi Fakultas Agro Teknologi Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/agroprimatech.v7i1.4416

Used cooking oil waste is very dangerous for the environment if it is not used or processed properly. Used cooking oil can be used as a raw material for used cooking oil mixed with areca nut. Areca nut contains substances that are beneficial for skin health such as tannins, alkaloids, and flavonoids. In improving the quality of this organic soap, biosurfactants from lerak fruit can also be added as a mixture of organic soaps. This research aims to develop an organic soap based on used cooking oil and areca nut extract with lerak fruit biosurfactant to improve skin health and reduce negative environmental impacts. The research method used a 2 factorial completely randomized design with factor 1, namely areca nut extract (P) which consisted of 3 levels: 4 mL, 6 mL, and 8 mL. Factor 2 was lerak fruit extract (L) which consisted of 3 levels, namely 35%, 45%, and 55%. The research results obtained that activated charcoal and zeolite are very effective in absorbing impurities contained in used cooking oil. This can be seen from the clear golden yellow color of the used cooking oil that has been purified. In organoleptic testing, it was found to have a dark red color, a characteristic odor and a thick texture. The results showed that the addition of areca nut extract and lerak fruit extract had a very significant effect on the results of variance where P<0.05 for all test parameters. The best treatment was found in P3L3 where 8 mL of areca nut extract and 55% of lerak fruit extract resulted in a pH of 8.89, foam height of 10.4 cm, foam stability of 97%, water content of 34.97%. The results of all treatments show that they have fulfilled SNI 06-4085-1996 which can be used as organic liquid body soap. Keyword: lerak, organic soap, used cooking oil, areca nut, biosurfactant

Pengaruh konseling obat terhadap pengetahuan dan tingkat kepatuhan pasien hipertensi Tahun 2023 Nainggolan , Intan; Nurasni, Nurasni; Simanjuntak, Nerly Juli Pranita; Novriani , Erida; Piska , Finna; Meutia , Rena; Neswita, Elfia
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.507

Hypertension is when blood pressure exceeds normal limits, and it is generally a lifelong condition that requires maintaining stable blood pressure. Every year, the relationship between hypertension and death from heart and blood vessel disease stabilizes. Every year, the link between hypertension and death from heart and blood vessel disease is proven. This research took place from July to September 2023 at H. Adam Malik Hospital, Medan, with 53 patients who met the inclusion criteria. The study aims to assess the level of adherence of hypertensive patients to the use of their medication using the Morisky Medication Adherence Scale questionnaire and to see whether counseling can increase the level of patient compliance. The results of the analysis show that providing counseling has a significant impact on increasing compliance in hypertensive patients at H.Adam Malik General Hospital, Medan, as demonstrated by the Wilcoxon test with p-value < 0.05.

Antibacterial activity of dali ni horbo protein extract modified with citrus and pineapple juice Tesa, Catrin Angelica Putri; Razoki, Razoki; Piska, Finna
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.7889

Background: The global rise in antibiotic resistance highlights the urgent need to identify novel, natural antimicrobial agents. Fermented dairy products represent potential sources of bioactive peptides with inherent antibacterial properties. Dali ni horbo is a traditional fermented buffalo milk product from North Sumatra, Indonesia. This study aimed to evaluate the in vitro antimicrobial activity of a crude protein extract from dali ni horbo, modified with orange and pineapple juice, against selected pathogenic microorganisms. Methods: This experimental laboratory study employed disk diffusion and well diffusion methods on agar media to assess the extract’s activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Propionibacterium acnes, and Candida albicans. Results: The results showed no inhibition zones for any treatment against all tested microorganisms. The absence of detectable antimicrobial activity may be attributed to the low concentration or biological activity of antibacterial compounds in the crude extract, the possible degradation of bioactive peptides during extraction, and the limited diffusion capacity of high‑molecular‑weight proteins in solid agar media. Conclusion: In conclusion, under the experimental conditions and methods applied, the crude protein extract of dali ni horbo did not exhibit antimicrobial activity against the tested bacterial and fungal species. Further studies involving protein purification, bioactive peptide isolation, and alternative liquid-based susceptibility assays are recommended.

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