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Novriani , Erida
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Uji Aktivitas Ekstrak Etanol Daun Bandotan (Ageratum conyzoides L) Terhadap Penyembuhan Luka Bakar Pada Tikus (Rattus norvegicus) Dengan Diabetes Melitus Afika, Nur; Yunus , Muhammad; Novriani , Erida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.935

Abstract

Burn wounds in patients with diabetes mellitus experience impaired healing due to chronic hyperglycemia. This study aims to identify phytochemical compounds, analyze the characteristics of crude drugs, and test the activity of ethanol extracts of bandotan leaves (Ageratum conyzoides L.) on burn wound healing in rats (Rattus norvegicus) with diabetes mellitus, including histological evaluation of wound tissue. Screening results showed that the extract contains active compounds such as alkaloids, flavonoids, tannins, saponins, quinones, and steroids. Herbal material characterization met standards for moisture and ash content but did not meet standards for water-soluble and ethanol-soluble extract content. The extract gel formulation was tested at three concentrations (5%, 10%, 15%). Efficacy tests showed that the 15% gel accelerated wound healing by 100% by day 15, with histological findings indicating increased numbers of fibroblasts, collagen fibers, and capillary blood vessels. This study concludes that ethanol extract of bandotan leaves has potential as an effective wound healing agent, particularly in diabetic conditions.
Pengaruh konseling obat terhadap pengetahuan dan tingkat kepatuhan pasien hipertensi Tahun 2023 Nainggolan , Intan; Nurasni, Nurasni; Simanjuntak, Nerly Juli Pranita; Novriani , Erida; Piska , Finna; Meutia , Rena; Neswita, Elfia
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.507

Abstract

Hypertension is when blood pressure exceeds normal limits, and it is generally a lifelong condition that requires maintaining stable blood pressure. Every year, the relationship between hypertension and death from heart and blood vessel disease stabilizes. Every year, the link between hypertension and death from heart and blood vessel disease is proven. This research took place from July to September 2023 at H. Adam Malik Hospital, Medan, with 53 patients who met the inclusion criteria. The study aims to assess the level of adherence of hypertensive patients to the use of their medication using the Morisky Medication Adherence Scale questionnaire and to see whether counseling can increase the level of patient compliance. The results of the analysis show that providing counseling has a significant impact on increasing compliance in hypertensive patients at H.Adam Malik General Hospital, Medan, as demonstrated by the Wilcoxon test with p-value < 0.05.
Uji Efektivitas Ekstrak Daun Kelor (Moringa oleifera) dalam Menurunkan Kadar Asam Urat pada Mencit (Mus Musculus) Yang Diinduksi Hati Ayam Sidauruk , Resti Novita; Novriani , Erida; Lubis , Razoki
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1328

Abstract

Background: Hyperuricemia is a metabolic disorder with an increasing prevalence and a risk of developing into gout if not properly treated. The use of allopurinol as a conventional therapy is effective in lowering uric acid levels; however, it may cause side effects, thus safer natural-based therapeutic alternatives are needed. Moringa leaves (Moringa oleifera) are known to contain bioactive compounds with potential antihyperuricemic activity. Objective: This study aimed to evaluate the effectiveness of Moringa leaf extract in reducing uric acid levels in mice (Mus Musculus) with hyperuricemia induced by chicken liver. Methods: This laboratory experimental study with a controlled group design used 30 mice divided into six groups (n = 5): normal control, negative control (5% Na-CMC), positive control (allopurinol 10 mg/kgBW), and three treatment groups receiving Moringa leaf extract at doses of 70, 140, and 280 mg/kgBW. Hyperuricemia was induced using chicken liver. Uric acid levels were measured daily for 7 days using a Multicheck Nesco® device. Data were analyzed using One-Way ANOVA followed by the Tukey Post Hoc test with a significance level of p < 0.05. Results: Chicken liver induction successfully increased uric acid levels in mice in all treatment groups (baseline levels of 3.26–3.42 mg/dL increased to 8.20–8.30 mg/dL). Moringa leaf extract showed a gradual and dose-dependent reduction in uric acid levels. The dose of 280 mg/kgBW provided the most optimal reduction effect (from 8.22 mg/dL to 3.44 mg/dL on day 7; p < 0.05), approaching the effectiveness of the positive control allopurinol (from 8.30 mg/dL to 3.52 mg/dL). Phytochemical screening confirmed the presence of active compounds such as flavonoids, alkaloids, saponins, phenols, and triterpenoids which play a role in inhibiting the xanthine oxidase enzyme. Conclusion: Moringa leaf extract effectively reduces uric acid levels in mice induced with hyperuricemia, with the dose of 280 mg/kgBW being the most optimal. Moringa leaf extract has potential to be developed as a natural-based antihyperuricemic therapeutic alternative.
Co-Authors Afika, Nur Finna Piska Lubis , Razoki Meutia , Rena Muhammad Yunus Nainggolan , Intan Neswita, Elfia nurasni, nurasni Sidauruk , Resti Novita Simanjuntak, Nerly Juli Pranita