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All Journal ALKIMIA : Jurnal Ilmu Kimia dan Terapan Journal of Medical Laboratory in Infectious and Degenerative Diseases Pharmacon: Jurnal Farmasi Indonesia
Mohammad Rofik Usman
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Determination of Nitrite Levels in Boiled White and Purple Cabbage Based on Boiling Time Variations Eka Fitri Yanti; Nur Nadia Faridha; Bannan Muthi'tul Af'idah; Istiqomah; Mohammad Rofik Usman
ALKIMIA Vol 10 No 1 (2026): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/57vkzs84

Abstract

Cabbage is a type of vegetable that contains various vitamins such as vitamins A, C, and K. One of the chemical components found in cabbage is nitrite (NO₂). Nitrite is a nutrient formed naturally with concentrations depending on species variation, season, light, and fertilizer use. This study aims to determine the nitrite levels in boiled purple and white cabbage with varying boiling times using the UV-Vis spectrophotometric method. Additionally, this research evaluates whether the nitrite content in the boiled cabbage remains within the Acceptable Daily Intake (ADI). The extraction was carried out using distilled water with boiling time variations of 0, 5, 10, 15, and 20 minutes. Nitrite levels were determined using the UV-Vis spectrophotometric method. The nitrite content found in white cabbage for boiling durations of 0, 5, 10, 15, and 20 minutes were 1.672 ppm, 0.986 ppm, 1.037 ppm, 0.951 ppm, and 0.999 ppm, respectively. For purple cabbage, the levels were 1.627 ppm, <0.5 ppm, 0.624 ppm, 0.775 ppm, and <0.5 ppm, respectively. The nitrite contents in both white and purple cabbage were found to be safe according to the ADI value of 4.2 mg/kg for a person weighing 60 kg.
In-Silico Study Of Bioactive Compounds In Bawang Dayak (Eleutherine palmifolia (L) Merr.) Bulbs On The Main Protease Receptor Of COVID-19 (6LU7) As A Candidate For SARS-CoV-2 Antivirus Drug Ulfa Dwi Septiana; Septyaningtyas Eka Wulandari; Nabila Kamalia; Tiara Anjelina Hezni; Mohammad Rofik Usman; Lindawati Setyaningrum
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.40

Abstract

: The COVID-19 viral disease is a new name given by the World Health Organization (WHO) to patients with the novel COVID-19 virus infection which was first reported from the city of Wuhan, China at the end of 2019. The COVID-19 pandemic is still a major problem in the world health. One antiviral regimen that is widely used to treat moderate to severe Covid- 19 patients is favipiravir. Many studies discuss alternative antiviral therapy for COVID-19 patients from active compounds contained in plants. One of the medicinal plants that has an antiviral effect on CoV-2 is Dayak onion (Eleutherine Palmifolia (L.) Merr). Consuming herbal plants can increase the body's immunity as the main key in preventing the Sars-Cov-2 virus. Purpose: This research aims to determine the effect of anchoring the active compound of Dayak onion bulbs on the growth of the corona virus on the main protease receptor for Covid 19 (6LU7). Methods: This type of research uses a molecular docking research method which consists of docking validation stages, a docking process and continues with docking visualization using Discovery Studio Visualizer and PyRx combined with Autodocktool Results: The results of the molecular docking simulation show that the Lysine sulfate compound has the lowest binding affinity value compared to Favipiravir, namely -4.75 kcal/mol with a Ki value of 96.41 μM and has the same interaction as the positive control ligand on the hydrophobic bond of MET A:165
The Effect of Banana Pell (Musa paradisiaca L) Ethanol Extract on The Blood Glucose Level of Diabetic Mice with Alloxan Induction Nur Jazilah; Fifteen Aprila Fajrin; Sholihatil Hidayati; Mohammad Rofik Usman
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.6555

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion, insufficient insulin hormones, or the inability to use insulin effectively. One of the traditional medicine use with DM is to control their blood glucose levels using herbal plants, namely the banana peel plant (Musa paradisiaca L.) which is rich in flavonoids, alkaloids, and tannins. This study aims to determine the effect of ethanol extract banana peel EEBP on glucose levels in mice with alloxan induction. The design of this study was a laboratory experiment, using male white mice (Mus musculus L) Balb/c strain, which were induced with alloxan at a dose of 200 mg/kg.bw. The mice were divided into six groups, namely normal, negative (CMC Na 0.5%), positive (glibenclamide 5 mg/kg.bw), and three groups of EEBP at a dose of 100 mg/kg.bw, 200 mg/kg.bw, and 400 mg/kg.bw. Blood glucose levels were evaluated on day 3 after induction, as well as day 7 and 14 after treatment. Blood glucose level data were analyzed using one-way ANOVA, followed by LSD post hoc test with 95% confidence level. The 400 mg/kg.bw dose of banana peel ethanol extract showed the highest percentage reduction in blood glucose levels, namely 65.83% ± 0.800, compared to other doses. Based on LSD statistical test, doses of 200 mg/kg.bw and 400 mg/kg.bw of EEBP showed no significant difference compared to the positive control (p>0.05). The optimal dose for reducing blood glucose levels in DM mice induced by alloxan is the treatment of EEBP in doses of 200 mg/kg.bw and 400 mg/kg.bw
Co-Authors Bannan Muthi'tul Af'idah Eka Fitri Yanti Fifteen Aprila Fajrin Istiqomah Hariyanto Lindawati Setyaningrum Nabila Kamalia Nur Jazilah Nur Nadia Faridha Septyaningtyas Eka Wulandari Sholihatil Hidayati Tiara Anjelina Hezni Ulfa Dwi Septiana