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All Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Alya Salsabila
Universitas Muhammadiyah Makassar
Health Professions Nursing Public Health

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Uji Aktivitas Farmakologi Ekstrak Daun Jambu Air (Syzygium Samarangense)Terhadap Mencit (Mus Musculus) Resky Aulifiyah Haswari B; Nur Sahra; Masnaeni Thamrin; Silvia Astuti; Diva Sukrianingsih; Nurul Nisai; Nur Alya Nazifa; Alya Salsabila; Andi Utari Prasetya Ningrum
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 4 No. 1 (2026): Januari : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v4i1.944

Abstract

This study aims to determine the pharmacological activity profile of water apple (Syzygium samarangense) leaf extract on male mice (Mus musculus) and to observe the effect of increasing doses on its pharmacological classification. The screening method involved observing 25 parameters, including behavioral, autonomic, and motoric responses, using three concentration levels: 1%, 2%, and 4%. The results showed that the extract exhibited diverse pharmacological effects, with the Central Nervous System (CNS) stimulation and CNS depression being the most prominent activities at a 1% concentration. Interestingly, as the concentration increased, specific effects like parasympathomimetic activity remained consistently significant across all doses (ranging from 18.29% to 21.46%). The observed parasympathomimetic effects such as increased urination and defecation suggest that the extract may promote intestinal motility and bladder contraction. Additionally, the presence of sympathomimetic and parasympatholytic activities indicates a complex interaction with the autonomic nervous system. In conclusion, Syzygium samarangense leaf extract possesses potential as a parasympathomimetic agent, which could be further investigated for treating hypertension through vasodilation or as a diuretic and digestive aid. Further specific testing is required to isolate the active compounds responsible for these effects.
Penentuan Nilai LC₅₀ Ekstrak Etanol 80% Daun Trembesi (Samanea saman (Jacq.) Merr.) Menggunakan Metode BSLT Haryanto Haryanto; Resky Aulifiyah Haswari.B; Aulya Nurul Imama R; Agung Nur Aqdi; Rahasia Rahasia; Ilmi Nurashilah; Alya Salsabila; Risya Nida Kaffyiah Sereang; Mawar Sahid
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 4 (2026): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i4.2353

Abstract

Samanea saman (Jacq.) Merr. leaves contain various secondary metabolites with potential biological activities; therefore, preliminary toxicity testing is necessary to evaluate their safety and bioactive potential. This study aimed to determine the Lethal Concentration 50 (LC₅₀) value of the 80% ethanol extract of Samanea saman leaves using probit analysis and to classify its toxicity level. An experimental study was conducted using the Brine Shrimp Lethality Test (BSLT) with Artemia salina Leach larvae as the test organism. The extract was tested at concentrations of 10, 100, 500, 1,000, and 5,000 ppm. Larval mortality was recorded after the incubation period, and the data were analyzed using probit analysis to determine the LC₅₀ value. The results showed that larval mortality increased with increasing extract concentration, reaching 18.42%, 23.33%, 45.83%, 70.83%, and 88.89%, respectively. Probit analysis revealed an LC₅₀ value of 301.72 mg/L (ppm). Based on the toxicity classification, this value falls into the moderately toxic category, indicating that the 80% ethanol extract of Samanea saman leaves exhibits toxic activity against Artemia salina larvae. These findings suggest that the extract has promising potential as a source of bioactive compounds and warrants further investigation, including the isolation and identification of active constituents, cytotoxicity evaluation, and safety assessment in more complex biological systems.
Co-Authors Agung Nur Aqdi Andi Utari Prasetya Ningrum Aulya Nurul Imama R Diva Sukrianingsih Haryanto Haryanto Ilmi Nurashilah Masnaeni Thamrin Mawar Sahid Nur Alya Nazifa Nur Sahra Nurul Nisai Rahasia Rahasia Resky Aulifiyah Haswari B Resky Aulifiyah Haswari.B Risya Nida Kaffyiah Sereang Silvia Astuti