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Nanda Aprilia
Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Hang Tuah, Indonesia

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Formulasi Nanoemulgel Minyak Cendana-Aloe Vera Berbasis Gelling Agent Derivat Selulosa: Studi Karakteristik Dan Stabilitas Dita Nurlita Rakhma; Nanda Aprilia; Yuyun Nailufa; Yuli Ainun Najih
Jurnal Pharmacopoeia Vol 5 No 1 (2026): Maret 2026
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v5i1.1286

Abstract

Minyak cendana memiliki potensi antiinflamasi untuk penanganan sunburn; namun, sifatnya yang mudah menguap dan kelarutan air yang rendah membatasi efektivitas topikalnya. Aloe vera secara luas telah diketahui memiliki efektivitas sebagai pelembab dan antiinflamasi. Kombinasi kedua bahan tersebut dalam formulasi topikal berbasis nanoemulgel memiliki potensi besar untuk dikembangkan. Sistem nanoemulgel dapat meningkatkan stabilitas dan penghantaran zat aktif ke kulit, sementara jenis gelling agent berperan penting dalam menentukan karakteristik fisik dan stabilitas sediaan. Penelitian ini bertujuan untuk mengevaluasi pengaruh jenis gelling agent terhadap karakteristik fisik dan stabilitas nanoemulgel minyak cendana. Tiga formula nanoemulgel diformulasikan menggunakan gelling agent derivate selulosa yang berbeda (MC, HPMC, dan HEC). Evaluasi fisik meliputi pengamatan organoleptis, pH, viskositas, daya sebar, daya lekat, ukuran partikel, indeks polidispersitas (PDI), serta uji stabilitas sentrifugasi. Data dianalisis menggunakan uji one-way ANOVA (p<0,05). Seluruh formula menunjukkan nilai pH yang sesuai dan droplet berukuran nano (30–50 nm) dengan PDI <0,35 yang menandakan distribusi homogen. Perbedaan signifikan ditemukan pada viskositas dan ukuran partikel (p<0.05). Formula berbasis HEC menunjukkan viskositas tertinggi dan ukuran partikel terkecil. Peningkatan viskositas berkaitan dengan penurunan mobilitas droplet serta peningkatan stabilitas fisik. Daya sebar berbanding terbalik dengan viskositas, sedangkan daya lekat tidak menunjukkan perbedaan signifikan antar formula. Seluruh formula tetap stabil secara fisik tanpa pemisahan fase setelah uji sentrifugasi. Jenis gelling agent berpengaruh signifikan terhadap karakteristik fisik nanoemulgel, dan formula berbasis HEC menunjukkan performa paling optimal dalam aspek karakteristik dan stabilitas fisik.
Formulasi Nanoemulgel Minyak Cendana-Aloe Vera Berbasis Gelling Agent Derivat Selulosa: Studi Karakteristik Dan Stabilitas Dita Nurlita Rakhma; Nanda Aprilia; Yuyun Nailufa; Yuli Ainun Najih
Jurnal Pharmacopoeia Vol 5 No 1 (2026): Maret 2026
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v5i1.1286

Abstract

Sandalwood oil possesses anti-inflammatory potential for sunburn management; however, its volatility and low water solubility limit topical effectiveness. Aloe vera is widely known for its effectiveness as a skin moisturizer and anti-inflammatory. The combination of sandalwood oil and aloe vera in a nanoemulgel-based topical formulation has great potential for development. Nanoemulgel systems may enhance stability and skin delivery, while the type of gelling agent critically influences physical characteristics and stability. This study aimed to evaluate the effect of different gelling agents on the physical characteristics and stability of sandalwood oil-aloe vera nanoemulgel. Methods: Three nanoemulgel formulations were prepared using different cellulose derivative gelling agents (MC, HPMC, and HEC). Physical evaluations included organoleptic assessment, pH, viscosity, spreadability, adhesiveness, particle size, polydispersity index (PDI), and centrifugation stability testing. Data were analyzed using one-way ANOVA (p<0.05). All formulations showed acceptable pH and homogeneous nano-sized droplets (30–50 nm) with PDI <0.35. Significant differences were observed in viscosity and particle size (p<0.05). The HEC-based formulation exhibited the highest viscosity and the smallest particle size. Increased viscosity was associated with reduced droplet mobility and improved physical stability. Spreadability showed an inverse relationship with viscosity, while adhesiveness was not significantly different among formulations. All formulations remained physically stable without phase separation after centrifugation. The type of gelling agent significantly affected the physical characteristics of nanoemulgel, and the HEC-based formulation demonstrated the most optimal performance in characteristics and physical stability.