Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Biology, Medicine, & Natural Product Chemistry IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)
Rezky Anggraeni
Universitas Trisakti
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Effect of Nano Chitosan Xylotrupes Gideon on Fibroblast Proliferation and Collagen Deposition in the Oral Mucosa of Rattus norvegicus Komariah Komariah; Muhammad Orliando Roeslan; Rezky Anggraeni; Didi Nugroho Santosa; Aubrey Kanya Rennata
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.23-30

Abstract

Lacerations of the oral mucosa are a common clinical problem and require an efficient healing process. The wound healing process involves the haemostasis, inflammation, proliferation, and maturation phases. During the proliferation phase, fibroblasts play an important role in migration and proliferation to produce collagen, which connects the wound's edges and provides strength and stability to the scar tissue that forms. Chitosan from the horned beetle (Xylotruphes gideon) contains active compounds that are thought to accelerate the healing process by increasing the activity of inflammatory cells and fibroblast proliferation. Physical modification into nanoparticles facilitates penetration into the mucosal layer, thereby accelerating collagen production and re-epithelialization. This study aimed to determine the effect of X. gideon nanokitosan administration on increasing fibroblast proliferation and collagen formation in vivo. The study was divided into five groups: positive control, negative control, and nano chitosan treatment at 3000, 1500, and 750µg/mL. All groups of experimental animals were previously given an injury to the right cheek mucosa with a No. 12 scalpel blade, and nano chitosan was administered topically. The increase in fibroblasts and collagen deposits was determined by HE and Masson's Trichrome staining on days 3, 7, and 14, which were observed microscopically and using ImageJ. The results showed a significant increase in fibroblasts on day 3 and collagen fibre deposition on day 14 in all treatment groups. The group with 750 ppm nano chitosan showed the best results in accelerating wound healing regarding fibroblast proliferation and collagen deposition. Conclusion: Nano chitosan X. gideon at a concentration of 750 ppm effectively accelerates wound healing in the cheek mucosa of mice by increasing fibroblast proliferation and collagen deposition.
Antibacterial Activity of Nanocomposite Chitosan-Silver Nanoparticle with Cymbopogon citratus Extract as a Bioreductor Against Staphylococcus aureus Rezky Anggraeni; Ananda Shelly Melyda; Alfred Pakpahan; Dewi Ranggaini; Johni Halim; Komariah Komariah
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 2 (2025): June 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v10.i2.112

Abstract

Nanocomposites are materials formed by combining two components, one or both of which are on the nanometer scale. The nanocomposite in this study is a combination of chitosan and silver nanoparticles produced through the synthesis of silver nitrate using Cymbopogon citratus extract. Silver nanoparticles have antibacterial abilities that can be utilized to overcome various diseases. However, their antibacterial properties may be reduced due to the tendency of silver nanoparticles to agglomerate. This can be overcome by the addition of chitosan as a stabilizing agent to prevent agglomeration and maintain the antibacterial effectiveness of silver nanoparticles. This study aims to evaluate the antibacterial activity of a nanocomposite formed by combining chitosan and silver nanoparticles synthesized using Cymbopogon citratus extract against Staphylococcus aureus through the diffusion method. The samples used included nanocomposites at concentrations of 6.25 mg/mL, 12.5 mg/mL, 15 mg/mL, 25 mg/mL, and 50 mg/mL, amoxicillin as a positive control, Acetic acid, and distilled water as negative controls. The results of antibacterial activity testing showed that all nanocomposite test concentrations had the ability to inhibit the growth of Staphylococcus aureus as evidenced by the formation of an inhibition zone around the disc paper. However, the highest antibacterial activity shown by the nanocomposites was still lower compared to the antibacterial activity of amoxicillin Keywords: Antibacterial activity, Chitosan, Cymbopogon citratus, Silver nanoparticles, Staphylococcus aureus
Co-Authors Alfred Pakpahan Ananda Shelly Melyda Aubrey Kanya Rennata Dewi Ranggaini Didi Nugroho Santosa Johni Halim Komariah Komariah Muhammad Orliando Roeslan