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All Journal African Journal of Clinical Medicine and Pharmacy Research
Peter Ise Uduak
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effect of Aqueous Hibiscus Sabdariffa on the Histology of the Testes of Male Albino Wistar Rats Charles Ayara; Williams Oche Ujah; Favour Joel Bafai; Victor Makanjuola; Kingsley Bassey Enang; Queen Uyo Williams; Tensaba Andes Akafa; Peter Ise Uduak; Isaac John Umaru
African Journal of Clinical Medicine and Pharmacy Research Vol 1 No 1 (2024): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v1i1.3974

Abstract

Medicinal plants contain physiological principles that over the years had been exploited in traditional medicine for the treatment of various ailments. Hibiscus Sabdariffa is not primarily a medicinal plant, but is used as alternative treatment to a wide variety of medical conditions. It is a plant of various psychoactive properties. This study investigated the histological effect of Hibiscus Sabdariffa aqueous solution on the testes of male albino rats. The research used 20 rats weighing 50-100g and were divided into Group A, Group B, Group C, Group D and Group E. Group A was the control group; unexposed to any form of Hibiscus Sabdariffa. Group B were exposed to the extract in a dosage of 0.5ml only in the morning. Group C were exposed to the extract in a dosage of 0.5ml in the morning and afternoon after (6) six hours. Group D were exposed to the extract in a dosage of 0.5ml in the morning, afternoon and by evening after six-hour intervals. Group E were exposed to the extract in an alternating administrative routine. In the end, the rats were sacrificed and the testes were removed and fixed in 10% formal saline solution. The testes were stained with hematoxylin and eosin. Results on the histology show changes to the histology of the testes of the group administered high doses. The results obtained from hormonal profiling shows a series of reduction in the levels of the evaluated hormones at the given dosage. Therefore, Hibiscus Sabdariffa can damage the histology of the testes at given dosage.
Co-Authors Charles Ayara Favour Joel Bafai Isaac John Umaru Kingsley Bassey Enang Queen Uyo Williams Tensaba Andes Akafa Victor Makanjuola Williams Oche Ujah