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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Rina Masadah
Hasanuddin University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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The Differences in Conjunctival Impression Cytology Profile, Interleukin-6 Levels in Tears, and Stages of Dry Eye Between Anophthalmic Socket and Contralateral Healthy Eye) Nur Aulia; Suliati Paduppai; Halimah Pagarra; Junaedi Sirajuddin; Rina Masadah; Rusdina Bte Ladju
Jurnal Penelitian Pendidikan IPA Vol 12 No 3 (2026): In Progress
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i3.14652

Abstract

Dry eye is one of the symptoms that can be suffered by anophthalmic socket eye, which is related to changes in the conjunctival epithelium and inflammatory processes in the anophthalmic socket eye. This study aims to determine differences in the degree of conjunctival impression cytology, tear pro-inflammatory cytokine interleukin-6 (IL-6), and degree of a dry eye between the anophthalmic socket eye and the contralateral healthy eye. This research is a cross-sectional study. Seventeen patients with anophthalmic socket eyes underwent conjunctival impression cytology examination, assessed tear levels of the pro-inflammatory cytokine IL-6, Schirmer test examination, and filled in the Dry Eye Questioner-5 (DEQ-5). The examination was performed simultaneously on the anophthalmic socket eye and the contralateral healthy eye. This study showed a significant difference in conjunctival impression cytokine (p= 0.004) and a significant difference in tear pro-inflammatory cytokine IL-6 levels (p= 0.014). There was no significant difference (p=0.319) in the results of the Schirmer 1 test, but there was a significant difference in the Schirmer 2 test (p=0.0047). There is a significant difference in the value of the DEQ-5 questionnaire (p = 0.003). There were significant differences in conjunctival impression cytology, tear pro-inflammatory cytokine IL-6, and degree of the dry eye between the anophthalmic socket eye and the contralateral healthy eye. Therefore, it is necessary to administer artificial tear drops to each patient with anophthalmic socket as a preventive measure for dry eye in the anophthalmic socket.
Transcranial Magnetic Stimulation Can Improve Cognitive Function and Brain-Derived Neurotrophic Peptide Levels in Post-Ischemic Stroke Patients Ulima Rahma Asri; Jumraini Tammasse; Andi Kurnia Bintang; Rina Masadah; Muhammad Akbar; David Gunawan Umbas
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.41

Abstract

ABSTRACT Background: Stroke can cause a significant burden of morbidity, including complications of impaired cognitive function. The problem being investigated is hypothesized to be related to brain-derived neurotrophic factor (BDNF), which can be increased by repetitive transcranial magnetic stimulation (rTMS). Purpose(s): To evaluate the effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on serum BDNF levels and cognitive function in ischemic stroke patients. Methods: A pre-test post-test control group, experimental study design, was applied to research conducted at Dr Wahidin Sudirohusodo Makassar and network hospitals in June 2023 until the sample size was met. All ischemic stroke patients who experienced impaired memory function were divided into control (medicamentous, n=10) and treatment (medicamentous + rTMS, n=11). Both at baseline and 14 days following therapy, their BDNF levels and MoCA-INA scores were assessed. ELISA examination is used to measure BDNF levels. The dependent T-test was used to analyze changes in MoCA-INA and BDNF scores in each group. Results: In the treatment group, the median MoCA INA score (26.00 (18.00-28.00) vs. 16.00 (13.00-21.00; p=0.001)) and BDNF levels (1.66 (0.78-3.59) vs. 1.55 (0.01-2.76); p=0.002) increased in two weeks. In contrast, the MoCA-INA score and BDNF levels in the control group did not show a statistically significant difference over a two-week period. MoCA-INA scores and BDNF levels in the treatment group showed a significant and favorable correlation, but not in the control group. Conclusion: rTMS can improve patients' cognitive function after ischemic stroke by improving BDNF levels. Keywords: Brain-derived neurotrophic factor, cognitive function, ischaemic stroke, repetitive transcranial magnetic stimulation
Co-Authors Andi Kurnia Bintang David Gunawan Umbas Halimah Pagarra Jumraini Tammasse Junaedi Sirajuddin Muhammad Akbar Nur Aulia Rusdina Bte Ladju Suliati Paduppai Ulima Rahma Asri