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Sylvia Winata
Universitas Prima Indonesia
Nursing Public Health

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Efektivitas Ekstrak Etanol Biji Alpukat (Persea americana Mill.) dalam Penurunan Hiperurisemia pada Mencit (Mus musculus L.) Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.764

Abstract

Hyperuricemia is a degenerative condition due to increased blood uric acid levels from purine metabolism, often occurring in the elderly. Avocado seeds (Persea americana Mill.) contain flavonoids with antioxidant and anti-inflammatory properties that can inhibit xanthine oxidation. This study evaluated the effectiveness of its extract in reducing uric acid levels in potassium bromate-induced male mice. Mice were divided into six groups: negative control (Na CMC 0.5%), positive control (allopurinol 10 mg/kg BW), three treatment groups (avocado seed extract 120, 150, and 180 mg/kg BW), and normal group. Uric acid levels were measured for seven days using one-way ANOVA test and BNT test LSD method. The results showed that doses of 120-180 mg/kg BW effectively reduced uric acid levels, with the optimal dose of 150 mg/kg BW reducing hyperuricemia by 37.3% (p = 0.118).
Co-Authors Astriani Natalia Asyrun Alkhairi Lubis Rena Meutia