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All Journal Jurnal Ners Jurnal Sains dan Teknologi Jurnal Kesehatan Amanah Journal of Pharmaceutical and Sciences. Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Asyrun Alkhairi Lubis
Universitas Prima Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Uji Efek Nefroprotektif Ekstrak Etanol Daun Sirih Hijau (Piper betle L.) pada Tikus Jantan yang Diinduksi Gentamisin. Tuti Putri Waruwu; Asyrun Alkhairi Lubis; Muhammad Yunus
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.47642

Abstract

Upaya nefroprotektif bertujuan untuk menjaga kesehatan ginjal dari risiko kerusakan.Tujuan dari studi ini adalah agar memahami pengaruh efek protektif terhadap ginjal serta menentukan dosis dalam jumlah yang tepat dari ekstrak etanol daun sirih hijau yang berfungsi sebagai agen pelindung ginjal.Studi melibatkan 25 ekor tikus jantan yang terbagi kedalam lima kelompok perlakuan berbeda,dimana kelompok kontrol normal tidak diberi perlakuan,Kelompok kontrol negatif yang diinduksi dengan gentamisin,serta kelompok uji yang menerima perlakuan ekstrak etanol daun sirih hijau dengan dosis brturut turut dari 100 mg/KgBB,150 mg/KgBB dan 200 mg/KgBB.Ekstrak diberikan melalui oral sekali sehari masa 8 hari,kemudian setiap hewan uji diberikan injeksi intraperitoneal gentamisin dengan dosis 80 mg/KgBB sejam setelah pemberian ekstrak,kecuali pada kelompok normal. Hasil pemeriksaan kreatinin hari 1 dan 9 mengindikasikan bahwa ekstrak etanol daun sirih hijau berpotensi sebagai agen nefroprotektif
Formulasi dan Evaluasi Sediaan Roll on Aromaterapi Minyak Atsiri Buah Andaliman (Zanthoxylum Acanthopodium Dc.) Novelia Zwi Dwinayanti Silaban; Roy Indrianto Bangar; Asyrun Alkhairi Lubis
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7535

Abstract

Andaliman (Zanthoxylum acanthopodium DC.) is an endemic spice from North Sumatra with significant therapeutic potential derived from its essential oils. Terpenoid compounds such as geranyl acetate, limonene, and citronellol in andaliman are recognized for their efficacy in aromatherapy to alleviate nausea and vomiting. This study aims to construct an aromatherapy roll-on formulation using andaliman fruit essential oil and to evaluate its physical characteristics and safety profile. The research employed a laboratory experimental method, utilizing the Stahl steam distillation technique for essential oil isolation. The preparations were formulated into three concentration variations: F0 (0%), F1 (5%), and F2 (10%). Evaluation parameters included organoleptic properties, homogeneity, viscosity, pH value, dermal irritation tests, and hedonic (preference) tests. The results demonstrated that all formulas maintained excellent physical stability and homogeneity. The pH values ranged from 5.52 to 6.06, which is considered safe as it aligns with the physiological pH of human skin (4.5–6.5). Irritation tests confirmed that the formulations did not trigger adverse skin reactions in respondents. According to the hedonic test, panelists showed high preference for aroma, texture, and comfort, although the scent longevity requires further optimization due to the volatile nature of the essential oil. Overall, the andaliman essential oil aromatherapy roll-on meets the physical quality and safety standards for topical preparations.
Pengujian Efek Proteksi Jus Tomat (Solanum Lycopersicum (L.)) Terhadap Fungsi Ginjal Tikus Yang Diinduksi Parasetamol Angelia Vega; Asyrun Alkhairi Lubis; Muhammad Yunus
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.763

Abstract

Excessive doses of paracetamol can cause nephrotoxicity due to accumulation of NAPQI and oxidative stress, which damages the proximal tubules of the kidney. Tomato (Solanum tomato L.) which is rich in lycopene has the potential to prevent this damage through its antioxidant activity. This experimental study used a posttest-only control group design with 25 white rats (Rattus norvegicus) divided into 5 groups: positive control, negative control, and three treatment groups. The mice were induced with toxic doses of paracetamol, while the treatment group was given tomato juice. Evaluation is carried out through measurement of plasma creatinine and renal histopathological analysis. The results showed that toxic doses of paracetamol (250 mg/kgBW) increased creatinine levels and relative kidney weight, which indicated acute kidney damage. Giving high doses of tomato juice (800 mg/kgBW) was most effective in reducing creatinine levels and protecting kidney tissue compared to lower doses. Administration of paracetamol 250 mg/kgBW caused kidney damage which was characterized by an increase in creatinine and relative kidney weight. Tomato juice at a dose of 800 mg/kgBW provided the best protective effect by reducing creatinine levels close to the positive control. These results demonstrate the potential of tomato juice as a protective agent against paracetamol-induced kidney damage.
Efektivitas Ekstrak Etanol Biji Alpukat (Persea americana Mill.) dalam Penurunan Hiperurisemia pada Mencit (Mus musculus L.) Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.764

Abstract

Hyperuricemia is a degenerative condition due to increased blood uric acid levels from purine metabolism, often occurring in the elderly. Avocado seeds (Persea americana Mill.) contain flavonoids with antioxidant and anti-inflammatory properties that can inhibit xanthine oxidation. This study evaluated the effectiveness of its extract in reducing uric acid levels in potassium bromate-induced male mice. Mice were divided into six groups: negative control (Na CMC 0.5%), positive control (allopurinol 10 mg/kg BW), three treatment groups (avocado seed extract 120, 150, and 180 mg/kg BW), and normal group. Uric acid levels were measured for seven days using one-way ANOVA test and BNT test LSD method. The results showed that doses of 120-180 mg/kg BW effectively reduced uric acid levels, with the optimal dose of 150 mg/kg BW reducing hyperuricemia by 37.3% (p = 0.118).
Potensi Aktivitas Antibakteri Antara Ekstrak dan Fraksi Kulit Jeruk Terhadap Ulkus Diabetes Farren Farren; Rena Meutia; Astriani Natalia Br Ginting; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.765

Abstract

Diabetic ulcers, a chronic complication of diabetes mellitus, result from long-term uncontrolled blood sugar levels and are characterised by infection-prone foot wounds. Staphylococcus aureus is often found as the bacteria that cause infection in these wounds. Antibiotic resistance has become a serious challenge in medicine, so alternatives such as orange peel (Citrus sinensis (L.) Osbeck) were investigated for their metabolite content with antibacterial potential. This study was designed experimentally with a Posttest Only Control Group Design approach. Orange peels were processed through sorting, drying, extraction using 96% ethanol, and fractionation with ethyl acetate. Antibacterial activity test was conducted by disc method against Staphylococcus aureus, using ethanol extract and ethyl acetate fraction. DMSO and mupirocin were used as negative and positive controls, with concentrations of 25%, 50%, and 75%. The results showed that the ethanol extract had antibacterial activity, with a concentration of 75% producing the largest inhibition zone (13.56 mm), including the medium category. However, the ethyl acetate fraction did not show antibacterial activity at all concentrations, presumably due to the low levels of extractable semipolar metabolites. Environmental factors such as UV light, humidity, and high temperature during drying are also thought to affect metabolite levels. It was concluded that ethanol extract of orange peel was more effective than ethyl acetate fraction in inhibiting the growth of Staphylococcus aureus.
Efek Gel Ekstrak Daun Sirsak (Annona Muricata L.) sebagai Agen Antiulkus pada Tikus Diabetes Induksi Aloksan : Studi Histologi Magdalena Tiara V Manihuruk; Muhammad Yunus; Asyrun Alkhairi Lubis
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 3 (2026): Juni 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i3.8119

Abstract

Diabetes Melitus is a chronic hyperglikemia codition that can impair wound healing due to distrupted tissue regeneration and alterrations in skin histological structure. Burn wounds under diabetic conditions tend to experience delayed healing as a result of decreased fibroblast activity, suboptimal collagen formation, and impaired angiogenesis. Soursoup leaves (Annona muricata l.) are known to contain bioactive compounds that may support the wound healing process. This study aimed to evaluate the effectiviness of soursoup leaf extract gel on burn wound healing in alloxan-induced diabetic rats through histological into six groups, consisting of a normal control, negative control, positive control ( Bioplacenton ), and treatment groups receiving soursoup leaf extract gel at concentration of 5%,10% and 15%. The observed parameters included the percentage of wound healing and histological festures of skin tissue, namely fibroblast count, collagen density and capillary formation. The result showed that administration of soursoup leaf increased number of fibroblast, improved collagen formation and enchanced skin tissue regeneration. Soursoup leaf extract gel has the potency accelerate burn wound heaing in alloxan-induced diabetic rats through improvement of skin tissue histological structure.
Formulasi dan Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Daun Sirsak (Annona Muricata L.) terhadap Bakteri Pseudomonas Aeruginosa Cristin Natali Rouli; Muhammad Yunus; Asyrun Alkhairi Lubis
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2090

Abstract

Soursop leaves (Annona muricata L.) are known to contain secondary metabolites such as alkaloids, flavonoids, tannins, saponins, and polyphenols, which have antibacterial potential. This study aimed to formulate soursop leaf extract into a gel dosage form and to evaluate its antibacterial activity against Pseudomonas aeruginosa. This research was conducted as an experimental laboratory study. Soursop leaf extract was obtained using the maceration method with 96% ethanol as the solvent and then formulated into gel preparations with extract concentrations of 5%, 10%, and 15%. Physical evaluation of the gel preparations included organoleptic test, homogeneity, pH, spreadability, and viscosity. Antibacterial activity was evaluated using the well diffusion method on Nutrient Agar medium. The results showed that all gel formulations met the physical requirements for topical preparations. The antibacterial activity test demonstrated that the soursop leaf extract gel inhibited the growth of Pseudomonas aeruginosa, with the 15% concentration producing the largest inhibition zone of 10 mm compared to other concentrations. In conclusion, soursop leaf extract gel has potential to be developed as a topical antibacterial agent against Pseudomonas aeruginosa.
Uji Efektivitas Nefroprotektif Ekstrak Buah Kersen (Muntingia calabura L.) Terhadap Histopatologi Dan Penanda Inflamasi Pada Tikus Putih Yang Diinduksi Gentamicin Superman Jaya Hulu; Asyrun Alkhairi Lubis; Hariyadi Dharmawan Syahputra
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1397

Abstract

Background: Kidney disease remains a major global health problem, one of which is associated with the use of nephrotoxic drugs such as gentamicin. Gentamicin induces renal damage through oxidative stress and inflammatory mechanisms. Muntingia calabura L. fruit contains bioactive compounds, including flavonoids and phenolic substances, which are believed to have nephroprotective properties. Objective: This study aimed to evaluate the nephroprotective effectiveness of Muntingia calabura fruit extract on renal histopathological changes and inflammatory markers in gentamicin-induced rats. Methods: This experimental laboratory study employed a post-test only control group design. A total of 25 male white rats were divided into five groups: negative control (0.5% CMC-Na), positive control (gentamicin 80 mg/kg BW), and three treatment groups receiving gentamicin 80 mg/kg BW combined with graded doses of Muntingia calabura fruit extract (50, 100, and 200 mg/kg BW) orally for 7 days. Renal histopathology was examined using hematoxylin-eosin (HE) staining, while serum interleukin-6 (IL-6) levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: Administration of Muntingia calabura fruit extract significantly reduced IL-6 levels and improved renal histopathological features compared to the positive control group (p < 0.05). The nephroprotective effect increased in a dose-dependent manner, with the highest dose (200 mg/kg BW) showing renal conditions closest to normal. Conclusion: Muntingia calabura fruit extract has potential as a natural nephroprotective agent against gentamicin-induced nephrotoxicity through inhibition of inflammatory response as indicated by decreased IL-6 levels.
Uji Efektivitas Nefroprotektif Ekstrak Buah Kersen (Muntingia calabura L) Terhadap Kadar Kreatinin Pada Tikus Putih Yang Diinduksi Gentamicin Femy Cecilia Marbun; Asyrun Alkhairi Lubis; Edy Fachrial
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1422

Abstract

Introduction: Gentamicin, an aminoglycoside antibiotic, is widely used for severe Gram-negative bacterial infections but poses a significant risk of nephrotoxicity, characterized by elevated serum creatinine levels. Muntingia calabura L. (cherry fruit) contains bioactive compounds with potential nephroprotective properties. Objective: This study aimed to evaluate the nephroprotective effect of cherry fruit extract on serum creatinine levels in gentamicin-induced white rats. Methods: An experimental post-test only control group design was employed using 25 male Wistar rats divided into five groups: normal control (K1), gentamicin control (K2), and treatment groups receiving gentamicin plus cherry fruit extract at doses of 100 (K3), 200 (K4), and 400 (K5) mg/kgBW. Gentamicin (100 mg/kgBW/day) was administered intraperitoneally for 7 days, while the extract was given orally for the same period. Serum creatinine levels were measured using the Jaffe method and analyzed using One-way ANOVA. Results: Serum creatinine levels in the gentamicin control group were 0.64 ± 0.09 mg/dL, while treatment groups K3, K4, and K5 showed levels of 0.62 ± 0.09, 0.61 ± 0.06, and 0.59 ± 0.10 mg/dL, respectively. Statistical analysis revealed no significant differences among groups (p > 0.05). A dose-dependent decreasing trend was observed, with the 400 mg/kgBW dose showing the lowest creatinine level, approaching the normal control value (0.55 ± 0.05 mg/dL). Conclusion: Cherry fruit extract demonstrated a tendency toward nephroprotective effects, indicated by dose-dependent reduction in serum creatinine levels; however, the effect was not statistically significant. Further research incorporating additional parameters, including BUN, renal histopathology, and oxidative stress biomarkers, is necessary to confirm its nephroprotective potential.
Co-Authors Angelia Vega Astriani Natalia Cristin Natali Rouli Edy Fachrial Farren Farren Femy Cecilia Marbun Ginting, Astriani Natalia Br Hariyadi Dharmawan Syahputra Magdalena Tiara V Manihuruk Muhammad Yunus Novelia Zwi Dwinayanti Silaban Rena Meutia Roy Indrianto Bangar S Superman Jaya Hulu Sylvia Winata Tuti Putri Waruwu