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All Journal Jurnal Kesehatan Amanah Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Rena Meutia
Universitas Prima Indonesia
Health Professions Nursing Public Health

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Efektivitas Ekstrak Etanol Biji Alpukat (Persea americana Mill.) dalam Penurunan Hiperurisemia pada Mencit (Mus musculus L.) Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.764

Abstract

Hyperuricemia is a degenerative condition due to increased blood uric acid levels from purine metabolism, often occurring in the elderly. Avocado seeds (Persea americana Mill.) contain flavonoids with antioxidant and anti-inflammatory properties that can inhibit xanthine oxidation. This study evaluated the effectiveness of its extract in reducing uric acid levels in potassium bromate-induced male mice. Mice were divided into six groups: negative control (Na CMC 0.5%), positive control (allopurinol 10 mg/kg BW), three treatment groups (avocado seed extract 120, 150, and 180 mg/kg BW), and normal group. Uric acid levels were measured for seven days using one-way ANOVA test and BNT test LSD method. The results showed that doses of 120-180 mg/kg BW effectively reduced uric acid levels, with the optimal dose of 150 mg/kg BW reducing hyperuricemia by 37.3% (p = 0.118).
Potensi Aktivitas Antibakteri Antara Ekstrak dan Fraksi Kulit Jeruk Terhadap Ulkus Diabetes Farren Farren; Rena Meutia; Astriani Natalia Br Ginting; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.765

Abstract

Diabetic ulcers, a chronic complication of diabetes mellitus, result from long-term uncontrolled blood sugar levels and are characterised by infection-prone foot wounds. Staphylococcus aureus is often found as the bacteria that cause infection in these wounds. Antibiotic resistance has become a serious challenge in medicine, so alternatives such as orange peel (Citrus sinensis (L.) Osbeck) were investigated for their metabolite content with antibacterial potential. This study was designed experimentally with a Posttest Only Control Group Design approach. Orange peels were processed through sorting, drying, extraction using 96% ethanol, and fractionation with ethyl acetate. Antibacterial activity test was conducted by disc method against Staphylococcus aureus, using ethanol extract and ethyl acetate fraction. DMSO and mupirocin were used as negative and positive controls, with concentrations of 25%, 50%, and 75%. The results showed that the ethanol extract had antibacterial activity, with a concentration of 75% producing the largest inhibition zone (13.56 mm), including the medium category. However, the ethyl acetate fraction did not show antibacterial activity at all concentrations, presumably due to the low levels of extractable semipolar metabolites. Environmental factors such as UV light, humidity, and high temperature during drying are also thought to affect metabolite levels. It was concluded that ethanol extract of orange peel was more effective than ethyl acetate fraction in inhibiting the growth of Staphylococcus aureus.
Aktivitas Nano Spray Gel Ekstrak Kulit Nanas (Ananas comosus L.) terhadap Pertumbuhan Bakteri Staphylococcus epidermidis pada Ulkus Diabetes Melitus Secara In Vitro Jesiska Muaratan; Astriani Natalia Br Ginting; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.659

Abstract

Diabetic ulcers are complications of diabetes mellitus often associated with bacterial infections like Staphylococcus epidermidis. Pineapple peel is rich in secondary metabolites including flavonoids with potential antibacterial effects. This study aimed to assesss the antibacterial activity of nano spray gel made with pineapple peel extract against Staphylococcus epidermidis through in vitro testing. This research employed a laboratory experimental design using nano spray gel formulations at varying concentrations of 25%, 50%, and 75% of pineapple peel extract. Flavonoids, alkaloids, tannins, and saponins are confirmed by phytochemical analysis. Only the formulation with 75% demonstrated antibacterial activity effect, with an average inhibition zone of 8.61 mm (medium category). 25% and 50% formulations show no inhibition. Pure extract showed a 15.42 mm zone (strong), while the positive control (clindamycin) produced 29.69 mm (very strong) inhibition zone. PSA results indicated particle size averaged 1480 nm, exceeding the nanoemulsion standard (<500 nm). Nano spray gel with 75% pineapple peel extract demonstrated antibacterial activity against S. epidermidis, although the particle size did not meet nanoemulsion criteria.
Co-Authors Astriani Natalia Astriani Natalia Br Ginting Asyrun Alkhairi Lubis Farren Farren Jesiska Muaratan Nerly Juli Pranita Simanjuntak Sylvia Winata