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All Journal Jurnal Ilmu Kedokteran dan Kesehatan JOURNAL OF Mother and Child Health Concerns
Zaleha Ulfa
Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Malahayati
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Risk factors for recurrent seizures in children with febrile seizures Novita Novita; Astri Pinilih; Zaleha Ulfa; Nina Herlina
THE JOURNAL OF Mother and Child Health  Concerns Vol. 4 No. 8 (2025): November Edition
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Persatuan Perawat Nasional Indonesia (PPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/mchc.v4i8.1806

Abstract

Background: Febrile seizure is defined as a seizure occurring in children aged 6–60 months with fever ≥38°C without intracranial infection. It is most common in children under three years, with a global prevalence of 2–5% and up to 12% in Asia. Although generally benign, recurrent febrile seizures may increase the risk of epilepsy later in life. Purpose: This study aimed to determine the risk factors associated with recurrent febrile seizures in children. Method: An analytical observational study with a cross-sectional approach was conducted using medical records of children diagnosed with febrile seizures. Bivariate analysis with chi-square test was applied to examine the association between risk factors and recurrence. Results: Children aged <2 years had a 2.5-fold higher risk of recurrence. Low birth weight (<2500 g) increased the risk by 2.5 times. A family history of febrile seizures was identified as a strong predictor of recurrence. Additionally, seizure onset with body temperature >39°C raised the risk by 4.5-fold. Conclusion: Age, low birth weight, family history, and high fever at seizure onset were significantly associated with recurrent febrile seizures. Early identification of these risk factors is essential for prevention and parental education to minimize recurrence and long-term complications.
Association of parity and age at menarche with molecular subtypes of invasive breast cancer Resti Arania; Amirah Zhafira Rizqiyanda; Zaleha Ulfa; Wien Wiratmoko
THE JOURNAL OF Mother and Child Health  Concerns Vol. 5 No. 4 (2026): July Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Persatuan Perawat Nasional Indonesia (PPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/mchc.v5i4.3675

Abstract

Background: Breast cancer is the most frequently diagnosed malignancy among women worldwide and remains a major public health concern. Reproductive factors, including parity and age at menarche, influence cumulative lifetime estrogen exposure and may contribute to the biological characteristics of breast cancer. However, evidence regarding their association with molecular subtypes of invasive breast cancer remains limited, particularly in Indonesia. Purpose: To determine the association between parity and age at menarche with the molecular subtypes of invasive breast cancer among patients treated. Methods: This analytic observational study employed a cross-sectional design using secondary data from medical records of 125 patients diagnosed with invasive breast cancer in 2025. Participants were selected using random sampling based on predefined inclusion and exclusion criteria. The independent variables were parity and age at menarche, while the dependent variable was the molecular subtype of invasive breast cancer determined by immunohistochemistry. Univariate analysis was used to describe participant characteristics, and bivariate analysis was performed using the Chi-square test. The strength of the associations was measured using Odds Ratios (ORs) with 95% confidence intervals (CIs). Statistical significance was established at p<0.05. Results: Most participants had a normal-to-late age at menarche (60.0%) and were multiparous or grand multiparous (52.0%). Luminal B was the predominant molecular subtype (32.0%), followed by Luminal A (27.2%), HER2 (22.4%), and Triple-Negative (18.4%). A significant association was observed between parity and molecular subtype (p=0.003; OR=0.282; 95% CI=0.119–0.672). Age at menarche was also significantly associated with molecular subtype (p=0.002; OR=0.229; 95% CI=0.087–0.606). Women with early menarche and nulliparity or primiparity were more likely to present with non-Luminal A molecular subtypes. Conclusion: Parity and age at menarche were significantly associated with the molecular subtypes of invasive breast cancer. Early menarche and low parity were more frequently associated with aggressive non-Luminal A molecular subtypes, highlighting the importance of reproductive history in breast cancer risk assessment and individualized management.
Analisis Hubungan Antara Kadar Thyroid Stimulating Hormone (TSH) Dan Jenis Kelamin Pada Pasien Hipertiroid Di Rumah Sakit Pertamina Bintang Amin Tahun 2025 Tria Zulfadlia; Rina Kriswiastiny; Zaleha Ulfa; Firhat Esfandiari
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 8 (2026): Volume 13 Nomor 8
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i8.25713

Abstract

Hipertiroid menjadi salah satu aspek penting dalam memahami karakteristik klinis penyakit tiroid. Hipertiroidisme adalah gangguan endokrin yang diindikasikan oleh hormon tiroid yang menyebabkan penurunan kadar TSH melalui mekanisme umpan balik negatif. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar TSH dan jenis kelamin pada pasien hipertiroid di Rumah Sakit Pertamina Bintang Amin tahun 2025. Penelitian ini merupakan penelitian analitik dengan pendekatan cross-sectional menggunakan data rekam medis. Sampel penelitian berjumlah 63 pasien. Analisis data dilakukan secara univariat menggunakan distribusi frekuensi dan persentase, sedangkan analisis bivariat menggunakan uji korelasi Spearman. Temuan studi ini mengungkapkan bahwasanya mayoritas pasien dengan kadar TSH rendah sebanyak 27 pasien (42,86%), diikuti kadar tinggi 20 pasien (31,75%) dan normal 16 pasien (25,40%). Berdasarkan jenis kelamin, mayoritas pasien adalah perempuan sebanyak 38 pasien (60,32%). Hasil analisis bivariat mengindikasikan adanya relasi yang signifikan dalam konteks statistik antara kadar TSH dan jenis kelamin (p = 0,038) dengan kekuatan hubungan yang lemah (r = 0,262). Oleh karena itu, kesimpulannya adalah mayoritas pasien hipertiroid memiliki kadar TSH rendah dan didominasi oleh perempuan. Ditemukan relasi secara signifikan antara kadar TSH dan jenis kelamin, meskipun kekuatan hubungan tergolong lemah.
The association of age, sex, residence, and parental occupation with acute lymphoblastic leukemia in children A Fatwa Alwaliu; Resti Arania; Zaleha Ulfa; Nita Sahara
THE JOURNAL OF Mother and Child Health  Concerns Vol. 5 No. 5 (2026): August 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Persatuan Perawat Nasional Indonesia (PPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/mchc.v5i5.4126

Abstract

Background: The Association of Age, Sex, Place of Residence, and Parental Occupation with Acute Lymphoblastic Leukemia in Children at Dr. H. Abdul Moeloek Regional General Hospital, Bandar Lampung. Acute lymphoblastic leukemia (ALL) represents the predominant hematologic malignancy affecting the pediatric population, with its development believed to be associated with both demographic and environmental determinants. Purpose: To examine the associations of age, sex, place of residence, and parental occupation (mother) with ALL among pediatric leukemia patients. Method: This analytical observational study used a cross-sectional design and secondary data from the medical records of 123 pediatric patients with leukemia at Dr. H. Abdul Moeloek Regional Hospital, Bandar Lampung, Indonesia, from January 2024 to December 2025. Total sampling was used. Data were analyzed using the Chi-square test or Fisher's exact test. Results: Among 123 pediatric leukemia patients, 104 (84.6%) were diagnosed with ALL. Most patients were aged 1–5 years (44.7%), male (71.5%), lived in regency areas (81.3%), and had parents working as farmers/laborers (47.2%). Sex was significantly associated with ALL (p = 0.011; OR = 3.511; 95% CI: 1.283–9.607). Parental occupation was also significantly associated with ALL (p = 0.001). Age (p = 0.059) and place of residence (p = 0.196) were not significantly associated with ALL. Conclusion: Sex and parental occupation were significantly associated with ALL among pediatric leukemia patients, whereas age and place of residence were not. Further studies should assess specific occupational and environmental exposures to clarify potential risk factors for childhood ALL.
Co-Authors A Fatwa Alwaliu Amirah Zhafira Rizqiyanda Astri Pinilih Firhat Esfandiari Nina Herlina Novita Novita Resti Arania Rina Kriswiastiny Sahara, Nita Tria Zulfadlia Wien Wiratmoko