Wien Wiratmoko
Universitas Malahayati

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Survival Life Penderita Kanker Payudara Berdasarkan Stadium Di Rumah Sakit Umum Daerah Dr. H. Abdul Moeloek Provinsi Yuniastini Yuniastini; Esteria Marhayuni; Wien Wiratmoko; Enzen Arif Februase
MAHESA : Malahayati Health Student Journal Vol 2, No 2 (2022): Volume 2 Nomor 2 (2022)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (238.829 KB) | DOI: 10.33024/mahesa.v2i2.4557

Abstract

ABSTRACT In the United States, 40,920 women died in 2018 from breast cancer. In Indonesia In 2010 more than 80% were found to be at an advanced stage. At the Regional General Hospital Dr. H. Abdul Moeloek, Lampung Province, as one of the types A class referral hospitals in 2018, there were 204 breast cancer sufferers. This study aims to analyze the life of breast cancer sufferers in 2015-2020 based on the stage at the Regional General Hospital Dr. H. Abdul Moeloek, Lampung Province. Population and research sample of breast cancer patients diagnosed and recorded in the medical records of the Regional General Hospital Dr. H. Abdul Moeloek, Lampung Province who met the inclusion and exclusion criteria and selected by purposive sampling a number of 48 events, with an analytic observational design and the type of survival analysis. Most of the sufferers who suffered at the Regional General Hospital Dr. H. Abdul Moeloek, Lampung Province have a stage 1 of 20%, followed by patients with stage 2 by 20% and patients with stage 3 by 30%, and patients with stage 4 by 30%. In breast cancer patients who have stage 4, no one survived until year 5. In the second year, 100% died (survived only until year 2). The results of survival studies in patients with stage 4 breast cancer survived only until the second year. (fifth years survival 0%). Therefore, providing education about breast self-examination in order to prevent the potential for cancer and provide support to sufferers and their families so that they can continue to undergo routine treatment. Keywords: Breast cancer, Stage, Fifth years survival life. ABSTRAK Amerika Serikat mencatat ada 40.920 wanita meninggal pada 2018 akibat kanker payudara. Di Indonesia Tahun 2010 lebih dari 80% ditemukan berada pada stadium lanjut. Di Rumah Sakit Umum Daerah Dr. H. Abdul Moeloek Provinsi Lampung, sebagai salah satu rumah sakit rujukan berkelas tipe A pada tahun 2018 didapat 204 penderita kanker payudara. Penelitian ini bertujuan untuk menganalisis survival life penderita kanker payudara tahun 2015-2020 berdasarkan Stadium di Rumah Sakit Umum Daerah Dr. H. Abdul Moeloek Provinsi Lampung. Populasi dan sampel penelitian merupakan penderita kanker payudara yang terdiagnosa dan terdaftar pada rekam medik Rumah Sakit Umum Daerah Dr. H. Abdul Moeloek Provinsi Lampung yang memenuhi kriteria inklusi dan eksklusi serta dipilih secara purposive sampling sejumlah 48 penderita kejadian, dengan desain observasional analitik serta jenis analisis survival. Sebagian besar penderita yang ditangani di Rumah Sakit Umum Daerah Dr. H. Abdul Moeloek Provinsi Lampung memiliki stadium 1 sebesar 20%, diikuti pada penderita dengan stadium 2 sebesar 20% dan penderita dengan stadium 3 sebesar 30%, serta penderita dengan stadium 4 sebesar 30%. Pada penderita kanker payudara yang memiliki stadium 4, tidak ada yang bertahan hidup sampai tahun ke 5. Pada tahun kedua 100% meninggal (bertahan hidup hanya sampai tahun ke 2). Hasil penelitian ketahanan hidup pada penderita kanker payudara stadium 4 bertahan hidup hanya sampai tahun kedua. (survival life tahun kelima 0%). Oleh karena itu, pemberian edukasi mengenai pemerikasaan payudara sendiri (sadari) agar dapat tercegahnya potensi kanker dan memberikan dukungan terhadap penderita serta keluarganya sehingga dapat terus menjalani pengobatan rutin. Kata kunci: Kanker payudara, Stadium, Ketahanan hidup 5 tahun (survival life).
Association of parity and age at menarche with molecular subtypes of invasive breast cancer Resti Arania; Amirah Zhafira Rizqiyanda; Zaleha Ulfa; Wien Wiratmoko
THE JOURNAL OF Mother and Child Health  Concerns Vol. 5 No. 4 (2026): July Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Persatuan Perawat Nasional Indonesia (PPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/mchc.v5i4.3675

Abstract

Background: Breast cancer is the most frequently diagnosed malignancy among women worldwide and remains a major public health concern. Reproductive factors, including parity and age at menarche, influence cumulative lifetime estrogen exposure and may contribute to the biological characteristics of breast cancer. However, evidence regarding their association with molecular subtypes of invasive breast cancer remains limited, particularly in Indonesia. Purpose: To determine the association between parity and age at menarche with the molecular subtypes of invasive breast cancer among patients treated. Methods: This analytic observational study employed a cross-sectional design using secondary data from medical records of 125 patients diagnosed with invasive breast cancer in 2025. Participants were selected using random sampling based on predefined inclusion and exclusion criteria. The independent variables were parity and age at menarche, while the dependent variable was the molecular subtype of invasive breast cancer determined by immunohistochemistry. Univariate analysis was used to describe participant characteristics, and bivariate analysis was performed using the Chi-square test. The strength of the associations was measured using Odds Ratios (ORs) with 95% confidence intervals (CIs). Statistical significance was established at p<0.05. Results: Most participants had a normal-to-late age at menarche (60.0%) and were multiparous or grand multiparous (52.0%). Luminal B was the predominant molecular subtype (32.0%), followed by Luminal A (27.2%), HER2 (22.4%), and Triple-Negative (18.4%). A significant association was observed between parity and molecular subtype (p=0.003; OR=0.282; 95% CI=0.119–0.672). Age at menarche was also significantly associated with molecular subtype (p=0.002; OR=0.229; 95% CI=0.087–0.606). Women with early menarche and nulliparity or primiparity were more likely to present with non-Luminal A molecular subtypes. Conclusion: Parity and age at menarche were significantly associated with the molecular subtypes of invasive breast cancer. Early menarche and low parity were more frequently associated with aggressive non-Luminal A molecular subtypes, highlighting the importance of reproductive history in breast cancer risk assessment and individualized management.