Kangaroo Mother Care (KMC) is a skin-to-skin care method that can improve physiological stability and support successful breastfeeding in newborns. KMC may also improve clinical outcomes among preterm and low birth weight (LBW) infants. However, findings regarding the effectiveness of KMC remain inconsistent. This study aimed to evaluate the effect of KMC on breastfeeding rate and hospital stay among preterm and LBW infants. This study employed a systematic review and meta-analysis design following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Literature searches were conducted through PubMed and SpringerLink using keywords related to KMC, breastfeeding, and hospital stay. Studies were selected based on predetermined inclusion and exclusion criteria through title, abstract, and full-text screening. Extracted data included study characteristics, sample size, intervention, and study outcomes. Data were analyzed using Comprehensive Meta-Analysis (CMA) version 3.0. The effect size was expressed as the Standardized Mean Difference (SMD) with a 95% confidence interval (CI). The meta-analysis showed that KMC significantly increased breastfeeding rate compared with conventional care, with an SMD of 0.81 (95% CI: 0.55–1.07; p < 0.001). KMC also significantly reduced hospital stay, with an SMD of −0.54 (95% CI: −0.61 to −0.47; p < 0.001).