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All Journal Majalah Obat Tradisional JPSCR : Journal of Pharmaceutical Science and Clinical Research
Safitri, Listiyana Ika
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Environmental Science Health Professions Medicine & Pharmacology Public Health

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Hepatoprotective Effects of Milkfish (Chanos chanos) Oil and Silymarin Against Isoniazid–Rifampicin-Induced Liver Injury in Rats Sasongko, Heru; Hovhanness, Mikael; Sawitri, Arinda Handiyah; Maharani, Aulia Hanundita; Hedianti, Delia Putri; Hutasoit, Josua Arianto; Asyraq, Lathyfa; Safitri, Listiyana Ika; Zai, Lois Elda; Sutarno, Sutarno
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.101531

Abstract

The objectives of the present research were to assess the hepatoprotective activities of milkfish oil (MFO) and silymarin (SL) against rifampicin (RFP) and isoniazid (INH) induced hepatotoxicity. Rats were divided into seven groups: normal control, negative control (INH+RFP), silymarin alone (50 mg/kg BW/day), low-dose MFO (MFO-L), high-dose MFO (MFO-H), low-dose combination (SL+MFO-L), and high-dose combination (SL+MFO-H). Rats receiving RFP and INH showed raised liver enzymes and typical signs of hepatotoxicity. Analyzed parameters comprised proinflammatory mediators (tumor necrosis factor-alpha and interleukin-6), antioxidant markers (catalase, glutathione, malondialdehyde, and superoxide dismutase), cytochrome P450, total protein, aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin and bilirubin. Treatment with a combination of MFO plus SL remarkably decreased hepatic enzyme activities, oxidative stress and inflammation, and suggested a prevention effect against the drug-induce liver injury.
Caesalpinia sappan Reduce Fever with An Anti-inflammatory and Antioxidant Mechanism: A Review Sasongko, Heru; Hedianti, Delia Putri; Safitri, Listiyana Ika
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.79562

Abstract

Caesalpinia sappan L (Sappan wood) is an herbal plant that has long been trusted by the public as an herbal medicine for tuberculosis, diarrhea, dysentery, skin infections, anemia, and other diseases by utilizing the decoction of C.sappan. Sappan wood is an herbal plant widely used as a raw material for traditional medicinal products. Sappan wood has been reported to have substantial pharmacological effects in analgesic, antioxidant, antibacterial, anti-inflammatory, and anti-viral. Fever is a clinical manifestation of certain conditions or diseases characterized by increased body temperature above the normal range (36.5–37.5 °C). Many studies declare that antioxidant and anti-inflammatory activity in C.sappan reduces oxidative stress and pro-inflammatory cytokines. This literature review shows that the antioxidant and anti-inflammatory properties of C.sappan are linked to fever as a sign of illness. Literature review using the last ten years' Scopus, ScienceDirect, and Pubmed databases. There are as many as 20 journals regarding sappan wood's antioxidant and anti-inflammatory effects. Sappan wood has been shown to have an antioxidant effect by lowering reactive oxygen species levels via SOD, GPx, or CAT markers. It inhibits inflammation cytokines such as IL-1, IL-6, TNF-?, and INF produced during fever. Sappan wood also has an anti-inflammatory effect by inhibiting PGE2 production when someone has a fever. The findings of our review state that C.sappan can be used to treat fever for both of these reasons. The use of C.sappan as a component in producing traditional health beverages has potential.
Co-Authors Asyraq, Lathyfa Hedianti, Delia Putri Heru Sasongko Hovhanness, Mikael Hutasoit, Josua Arianto Maharani, Aulia Hanundita Sawitri, Arinda Handiyah Sutarno Sutarno Zai, Lois Elda