Aksesibilitas menjadi tantangan utama dalam e-learning bagi penyandang tunanetra karena keterbatasan visual dalam memahami konten digital. Penelitian ini bertujuan mengembangkan sistem e-learning inklusif dengan fitur voice command dan text-to-speech untuk mendukung interaksi non-visual. Pengembangan sistem dilakukan menggunakan metode Agile Scrum dalam beberapa siklus sprint, yang mencakup tahapan product backlog, sprint planning, daily scrum, sprint review, dan sprint retrospective. Sistem dirancang dalam arsitektur tiga lapisan, dengan React.js pada sisi klien dan Node.js pada sisi server, serta mengintegrasikan layanan API Gemini untuk pemrosesan suara dan teks ke audio. Validasi sistem dilakukan secara internal melalui dokumentasi sprint review dan skenario pengujian teknis. Hasil dokumentasi sprint menunjukkan bahwa fitur ini berfungsi sesuai dengan skenario pengujian internal dan berpotensi meningkatkan aksesibilitas. Meskipun belum dievaluasi langsung oleh pengguna tunanetra, hasil pengembangan awal ini memberikan fondasi penting untuk pengujian lebih lanjut dan pengembangan sistem e-learning yang lebih inklusif. Absctract Accessibility is a major challenge in e-learning for visually impaired individuals due to visual limitations in understanding digital content. This study aims to develop an inclusive e-learning system with voice command and text-to-speech features to support non-visual interaction. The system was developed using the Agile Scrum method in several sprint cycles, which included the product backlog, sprint planning, daily scrum, sprint review, and sprint retrospective stages. The system is designed with a three-layer architecture, using React.js on the client side and Node.js on the server side, and integrates the Gemini API service for voice and text-to-audio processing. System validation was conducted internally through sprint review documentation and technical testing scenarios. The sprint documentation results indicate that this feature functions according to internal testing scenarios and has the potential to improve accessibility. Although it has not yet been directly evaluated by visually impaired users, these initial development results provide an important foundation for further testing and the development of a more inclusive e-learning system.