Perubahan Patologi Seluler Kelenjar Adrenal Tikus Hipertensi dengan Terapi Sel Punca Mesenkimal Sumsum Tulang (CELLULER STUDY OF ADRENAL GLAND IN HYPERTENSIVE RATS WITH IMPACT OF BONE MARROW MESENCHYMAL STEM CELLS THERAPY)

Yanse Yanne Rumlaklak (Sekolah Pascasarjana, Institus Pertanian Bogor Babakan, Dramaga, Bogor, Jawa Barat. Indonesia 16680)
Erni Sulistiawati (Pusat Studi Satwa Primata, Lembaga Penelitian dan Pengabdian Kepada Masyarakat IPB.)
Dondin Sajuthi (Departemen Klinik, Reproduksi dan Patologi, Fakultas Kedokteran Hewan, IPB)
Sus Derthi Widhyari (Departemen Klinik, Reproduksi dan Patologi, Fakultas Kedokteran Hewan, IPB)
Setyo Widi Nugroho (Departemen Bedah Saraf, Fakultas Kedokteran, Universitas Indonesia)

Jurnal Veteriner
Vol 19 No 2 (2018)

The purpose of this study was to investigate changes in cellular pathology of adrenal gland as impact of bone marrow mesenchymal stem cells (BMMSC) therapy in hypertensive rats. The research used ten male wistar rats with age ± 10-12 weeks with body weight ± 200-250 grams which is devided into two different groups ie BMMSc(-) hyprtention and BMMSc(+) hypertension. Rats are conditioned with hypertention using Hasbinoto et al method. Right nephrectomy and left carotid communic artery ligation are performed on all rats. Rats are injected with deoxycorticosterone acetate (DOCA), then 0.12 % of âaminopropionitrile fumarate (BAPN) is added into drinking water. 1% NaCl solution was administered as drinking water during the study. Rats were evaluated for particular indicator ie blood pressure then were euthanized for adrenal organs collections. The data that obtained then analysed using qualitative descriptive. The result of the study indicate hypertention therapy using BMMSC can repair cell damaged of the adrenal gland such as hyperplasia, nodules, cysts and cytoplasm vacuolization.