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All Journal Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Jurnal Veteriner WARTAZOA Indonesian Bulletin of Animal and Veterinary Sciences Jurnal Medik Veteriner ARSHI Veterinary Letters JURNAL KAJIAN VETERINER Jurnal Kedokteran Hewan
Sus Derthi Widhyari
Divisi Penyakit Dalam, Departemen Klinik, Reproduksi, Dan Patologi, Fakultas Kedokteran Hewan, Institut Pertanian Bogor Jl Agathis, Kampus IPB Dramaga, Bogor, Jawa Barat, Indonesia 16680
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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The Role and Deficiency of Zinc Mineral in Immune System Widhyari, Sus Derthi
Indonesian Bulletin of Animal and Veterinary Sciences Vol 22, No 3 (2012)
Publisher : Indonesian Animal Sciences Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (225.953 KB) | DOI: 10.14334/wartazoa.v22i3.848

Abstract

Zinc (Zn) is a micro mineral which is needed by every cell in the body. Adequate Zn mineral is important in maintaining optimal health. Zn functions as a cofactor of various enzymes, structural integrity of cells, DNA synthesis, hormonal storage and release,  immunotransmision  and  immune  system.  Zn  deficiency causes  decreased  appetite,  dermatitis,  growth  retardation, delayed sexual maturation, infertility and imunodeficiency. This is associated with changes in the function of immune system response, such as decreased B and T cell functions, reduced phagocytosis and decreased cytokine production. Severe Zn deficiency is characterized by severely depressed immune function and frequent infections. Zn enhances immune function for specific and non-specific immunity. The role of non-specific immune respone is through the activity of cells phagocytosis by neutrophils and monocytes, while the specific immune response can be humoral and cellular mediated by lymphocytes B and T. Supplementation of Zn can improve the activity of leukocyte cells through stimulating the production of tumor necrosis factor- alpha (TNF-α) by monocytes cells, thereby increasing the ability of phagocytosis. In addition, Zn is also able to increase the production of lymphokines that cause lymphocyte cells able to differentiate and proliferate.   Key words: Zn, deficiency, immunity, leucocyte cells
Efektifitas pemberian kombinasi mineral zinc dan herbal sebagai imunomodulator Sus Derthi Widhyari; Ietje Wientarsih; Harry Soehartono; I Putu Kompiang; Wiwin Winarsih
Jurnal Ilmu Pertanian Indonesia Vol. 14 No. 1 (2009): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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Abstract

Suplemen as imunomodulator used to increase immune response, to prevent disease. Herb and Zinc (Zn) can function as imunostimulan. The aim of this experiment was (1) to studythe effect of Zn mineral and herb combination influence the healthy condition, performance and immunity responses, 2) to have blood biochemistry and organ function in broiler who given zinc mineral and herb combination, 3) to know the effectivity of herb and Zn to be treated by Colibacillosis condition One hundred broiler were used in this research, divided by 5 groups: RO (control), R1 (RO + 2.5% garlic powder+ 1.5% turmeric powder), R2 (R0+2.5% garlic powder+ZnO 120ppm), R3 (R0+1.5% turmeric powder+ZnO 120ppm), R4 (R0+2.5% garlic powder +1,5% turmeric powder and ZnO 120ppm). The parameters in this research are the erythrocyte count, hemoglobin, and pack cell volume and total leucocyte. Blood biochemistry are investigate protein total, albumin, alanine aminotransferase (AL T), aspartat aminotransferase (AST), creatinin and ureum. The research showed that the erythrocyte count, hemoglobin, and pack cell and blood biochemistry in normal value, that explain safety for organ function and health group showing health status and performance is good, tested in ability to attack Colibasilosis. The result of research show and hematologi in normal, The age of chicken was 3 weeks, all of groups were treated by innoculum of Eschericia coli (E. col!) bacteria with 108 CFU.mr1 doses per-ons. The parameter was based on performance, health condition, and immunity responses. The activity and the capacity of phagositosis for assessments immunity respons, the result showed to decerease the performance and healthy condition at the first week infection, then converse to improve at the second week. The amount of leucocyt cell, especially heterophyl cell was increased at 1 week after infection as being indicated by the appearance of innoculum E. coli bacteria. The amount of leaucocyt cell was decreased directly after 2 weeks post infection at the group that was fed by turmeric-Zn (P1) and gave antibiotic (K+) drug. This condition showed that the body defence fastly to eliminate the infected agent which was supported by increasing phagocyitosis capacity (327±111 bacteria) and phagocyitosis activity 97%±10%, was compared with the control group (without drug) activity value 85±15% and phagocytosis capacity (176±118 bacteria). Feeding by turmeric-Zn combination showed better result which was compared to Garlic-Zn combination and the ability to increase healthy condition, performance and immunuity responses.
Profil protein total, albumin dan globulin pada ayam broiler yang diberi kungiy, bawang putih dan Zinc (Zn) Sus Derthi Widhyari; Anita Esfandiari; . Herlina
Jurnal Ilmu Pertanian Indonesia Vol. 16 No. 3 (2011): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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Abstract

The objective of this experiment was to study the effectiveness of turmeric, garlic and zinc supplementation on protein, albumin and globulin concentration of broiler. One hundred DOC were divided into five treatments, four replications, consist of five chicks in each replicate. The treatments were RO (basal diet as a control), R1 (RO + 1,5% turmeric powder +2,5 % garlic powder), R2 (RO + 2,5% garlic powder + 120 ppm zinc), R3 (RO +1,5% turmeric powder+ 120ppm zinc) and R4 (RO +1,5 turmeric powder+ 2,5% garlic powder + 120 ppm zinc). The diet contain 23,5% crude protein and 3215 kcal metabolizable energy. Blood samples were taken from axillary veins at the three and six weeks of age. The results showed that total protein and globulin concentration at 6 weeks slightly higher than 3 weeks old chicks but not significantly different (P>0.05). Albumin concentration were highest on R3 treatment. Total protein and globulin concentration washighest on the R2 treatment. In conclusion, the supplementation of garlic (2.5%) and ZnO (120 ppm) showed the best combination to improve immune response in broiler.
Diare pada sapi neonatus yang ditantang Escherichia coli K-99 Anita Esfandiari; Sus Derthi Widhyari; Ali Hujarat
Jurnal Ilmu Pertanian Indonesia Vol. 16 No. 3 (2011): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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Abstract

The objective of this experiment was to study the efficacy- of colostrum given to neonatal calves challenged by Escherichia coli (E. col!) K-99. Ten healthy calves devided into two groups i.e. colostrum group (given colostrum originated from cows vaccinated by E. coli) and non-colostrum group (given whole cow milk). Colostrum or milk were given to the calves at amounts of 10% of body weight directly after birth and Followed by the same amount every 12 h, for three days. Challenged were done orally to all newborn calves when they were 12 hours of ages, using live bacteria of E. coli K-99. Fecal samples were collected every 12 hours for one week. Results of the experiment indicated that all calves experienced diarrhea following challenge tests. However, the non colostrum group showed a frequent defecation, more liquid faeces, a longer length of diarrhea and more severe clinical signs of diarrhea. It was confirmed that E' coli found and every feacal Samples,collected. In conclusion, colostrums collected from cow vaccinated by E. coli showed protective properties against E. coli K-99 infection.
Respons Antibodi Anti ETEC K99 pada Induk Sapi Bunting Setelah Pemberian Vaksin Escherichia Coli Polivalen Anita Esfandiari; Sus Derthi Widhyari; Sri Murtini; Bayu Febram; Retno Wulansari; Leni Maylina
Jurnal Ilmu Pertanian Indonesia Vol. 19 No. 2 (2014): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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Abstract

The objective of this experiment was to detect antibody (IgG) against enterotoxigenic Escherichia coli (ETEC)K99 in the blood of cows vaccinated by Escherichia coli polyvalent vaccine. Eight dry cows were injectedsubcutaneously by polyvalent Escherichia coli twice prior to parturition. Before vaccinated, the cows were givenimmunomodulator orally for 3 days. Blood samples were drawn from coccigeal vein prior to the 1st vaccination,two week following the 1st vaccination and at 1, 2, and 4 weeks after the 2nd vaccination. Blood samples wereanalyzed for IgG and ETEC K99 using indirect Enzyme Linked Immunosorbent Assay (ELISA) assay. Results of theexperiment indicated that absorbance values of all vaccinated cows before the first vaccination until third weekfollowing the 2nd vaccination were below cut off values. The absorbance values then increased and were above cutoff values at fourth week following the 2nd vaccination. In conclusion, antibody against ETEC K99, were detected inthe blood of cows, fourth week following the 2nd vaccination.
Efek Penambahan Mineral Zn Terhadap Gambaran Hematologi pada Anak Sapi Frisian Holstein Sus Derthi Widhyari; Anita Esfandiari; Agus Wijaya; Retno Wulansari; Setyo Widodo; Leni Maylina
Jurnal Ilmu Pertanian Indonesia Vol. 19 No. 3 (2014): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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Abstract

The objective of this experiment was to determine the effects of zinc supplementation on health status in dairy calves. Nine Frisian Holstein (FH) at 6-10 months of age were used in this experiment and divided into three groups. First group (no added Zn) for control, the second group was added 60 ppm Zn, and the third group was added 120 ppm Zn. Zn was administered daily for three months. Blood samples were collected from the jugular vein and anticoagulated with EDTA. Whole blood were used for measuring erythrocytes, hemoglobin concentration, hematocrit value, total leukocyte count, and leukocyte cell types. The results showed that no difference among groups for hematological parameters and the value of hematology were in the range values references. In conclusion, 60 and 120 ppm Zn supplementation in the feed is relatively safe for health.
Tinjauan Penambahan Mineral Zn dalam Pakan Terhadap Kualitas Spermatozoa pada Sapi Frisian holstein Jantan Sus Derthi Widhyari; Anita Esfandiari; Agus Wijaya; Retno Wulansari; Setyo Widodo; Leni Maylina
Jurnal Ilmu Pertanian Indonesia Vol. 20 No. 1 (2015): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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Abstract

Bulls are expected to be able to produce a good quality and quantity of sperm. The objective of this experiment was to study the effect of Zn supplementation on the sperm quality, in Frisian holstein bulls. Ten bulls, 1618 months of age were used in this experiment. The experimental bulls were divided into two groups, i.e.,group without Zn supplementation (control) and group with 60 ppm of Zn supplementation. Zn supplementations were given everyday for a period of four months. Semen was collected by using artificial vaginaat the end of the experiment. Semen quality was evaluated macroscopically and microscopically. The variables measured were semen volume, semen pH, sperm motility, sperm concentration, sperm viability, and sperm abnormality. The results showed that Zn supplementation significantly increased sperm motility and sperm concentration (P<0.05), whereas there was no significant difference in other parameters.
Profil Kreatinin dan Nitrogen Urea Darah pada Anak Sapi Friesian Holstein yang Disuplementasi Zn Sus Derthi Widhyari; Anita Esfandiari; Aditia Dwi Cahyono
Acta VETERINARIA Indonesiana Vol. 3 No. 2 (2015): Juli 2015
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.41 KB) | DOI: 10.29244/avi.3.2.45-50

Abstract

Parameter kreatinin dan nitrogen urea darah atau blood urea nitrogen (BUN) dapat digunakan sebagai indikator untuk melihat adanya gangguan fungsi ginjal. Penelitian ini bertujuan untuk mengetahui kadar kreatinin dan BUN dalam serum anak sapi Friesian Holstein (FH) yang diberi suplementasi mineral Zn di dalam pakan. Penelitian ini menggunakan 9 ekor anak sapi FH yang sehat secara klinis dan umur berkisar antara 6-10 bulan. Hewan dibagi menjadi 3 kelompok, yaitu kelompok tanpa suplementasi Zn, kelompok yang diberi suplementasi Zn sebesar 60 ppm, dan kelompok yang diberi suplementasi Zn sebesar 120 ppm. Pengambilan sampel darah dilakukan melalui vena jugularis sebelum pemberian Zn dan setiap bulan setelah pemberian Zn selama 3 bulan. Sampel darah dalam bentuk serum dianalisis untuk kadar kreatinin dan BUN menggunakan alat spektrofotometer. Hasil pemeriksaan memperlihatkan bahwa kadar kreatinin darah berkisar antara 0,64 sampai 0,77 mg/dL, dan kadar BUN berkisar antara 8 sampai 19 mg/dL. Kadar kreatinin dan BUN darah pada anak sapi FH masih berada pada kisaran normal. Oleh karena itu suplementasi Zn 60 ppm maupun 120 ppm yang diberikan selama tiga bulan pada anak sapi FH relatif aman dan tidak menggangu fungsi ginjal.Kata kunci: mineral Zn, BUN, kreatinin, anak sapi Friesian Holstein. (Creatinin and Blood Urea Nitrogen Profiles on Friesian Holstein Calves Supplemented by Zn)Creatinine and blood urea nitrogen (BUN) can be used for indicator renal disfuction. The objective of this experiment was to study the concentration of creatinine and blood urea nitrogen in Friesian Holstein (FH) calves, received feed supplemented by Zn. Nine healthy Holstein calves, 6-10 months old were used in this experiment. The calves were devided into 3 groups, consisted of three calves, i.e. no supplementation (control), 60 ppm and 120 ppm of Zn supplementation. Blood sample were collected from jugular vein, before dan after supllementation Zn every month untill 3 months. Blood urea nitrogen and creatinine concentrations in serum were analysed using spectrophotometer. Results of the experiment had indicated that the creatinine and BUN concentration ranging between 0,64-0,77 mg/dL and 8-19 mg/dL, respectively. In conclusion, concentration of creatinine and Blood urea nitrogen were in a normal range. So the supplementation of Zn 60 and 120 ppm were given for three months in Friesian Holstein calves relatively safe for renal function.Keywords: zinc, blood urea nitrogen, creatinine, Friesian Holstein calves.
Pengamatan Profil Darah Domba Terinfestasi Larva Chrysomya Bezziana dan Diberi Terapi Krim Herbal Sus Derthi Widhyari; Aulia Andi Mustika; Ietje Wientarsih; Lina Noviyanti Sutardi; Arief Purwo Mihardi; Esti Dhamayanti
Acta VETERINARIA Indonesiana Vol. 6 No. 2 (2018): Juli 2018
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (733.616 KB) | DOI: 10.29244/avi.6.2.8-15

Abstract

Larva Chrysomya bezzianamerupakan penyebab kejadian miasispada hewan ternak, dan merupakan masalah cukup serius karena dapat merugikan secara ekonomi.Pengobatan secara kimiawi dapat beresiko terhadap residu yang ditimbulkan, oleh karena itu perlu dicari obat alternatif berupa obat herbal yang aman bagi tubuh. Penelitian ini bertujuan untuk mengetahui status kesehatan melalui pemeriksaan gambaran darah pada domba garut yang diinfestasi larva Chrysomya bezziana dan diberi terapi krim herbal sirih merah. Semua kelompok perlakuan dilakukan infestasi larva kecuali kelompok kontrol (K0). Pembuatan luka insisi dan diinfestasi 50 larva pada setiap lubang. Penelitian ini terdiri dari 5 kelompok perlakuan yaitu kelompok kontrol (K0), kelompok dengan terapi krim sirih merah 2% (P1), kelompok dengan terapi krim sirih merah 4% (P2), kelompok dengan terapi krim asuntol (KP), dankelompok tanpa terapi (KN).Pengambilan darah dilakukan pada awal pengamatan (pre terapi) dan akhir pengamatanyaitu hari ke-7 setelah terapi diberikan (post terapi). Parameter yang diamati berupa jumlah sel darah merah, kadar hemoglobin dan nilai hematokrit.Infestasi larva Chrysomya bezzianadan pemberian krim herbal sirih merah tidak berpengaruh terhadap jumlah eritrosit, nilai hematokrit, dan kadar hemoglobin.Hasil penelitian menunjukkan pemberian krim sirih merah 4% memberikan profil darah yang paling baik. Krim sirih merah memiliki kemampuan dalam penyembuhan luka
Konsentrasi IL-6 Serum terhadap Penyembuhan Luka Pasca Pemasangan Implan Paduan Logam pada Babi (Sus scrofa) Nabila Latifa Hafizsha; Gunanti Gunanti; Deni Noviana; Sus Derthi Widhyari
Acta VETERINARIA Indonesiana Vol. 9 No. 1 (2021): Maret 2021
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.9.1.21-29

Abstract

Penelitian ini bertujuan untuk mengetahui gambaran konsentrasi IL-6 serum pada fase akut dan kronis selama proses penyembuhan luka pasca pemasangan implan paduan logam pada vesika urinaria babi. Penelitian ini menggunakan 6 ekor babi jantan dan betina, usia 2-3 bulan, dengan bobot badan berkisar 25-30 kg yang dibagi ke dalam dua kelompok implan dan tiga waktu pengamatan. Implan logam yang digunakan adalah Zn-0.5Al sebagai kelompok I dan ZnMg(4x) sebagai kelompok II, sedangkan waktu pengamatan dilakukan pada hari ke-0, 14, dan 28. Pemasangan implan dilakukan pada vesika urinaria (VU) menggunakan teknik cystotomi. Pengukuran konsentrasi IL-6 serum menggunakan metode enzyme-linked immunosorbent assay (ELISA). Data dianalasis menggunakan analysis of variance (ANOVA). Hasil penelitian menunjukkan pada hari ke-0, implan Zn-0.5Al dan ZnMg(4x) berturut-turut adalah 1.38±2.40 pg/mL dan 0.10±0.17 pg/mL. Konsentrasi IL-6 hari ke-14 pada setiap implan terlihat mengalami penurunan dibandingkan pada hari ke-0, yaitu 0.74±1.29 pg/mL dan 0 pg/mL. Selanjutnya hari ke-28 konsentrasi IL-6 kembali mengalami penurunan, yaitu 0.32±0.35 pg/mL dan 0 pg/mL. Penurunan konsentrasi IL-6 dari fase akut ke fase kronis proses penyembuhan luka pada setiap kelompok implan tidak berbeda signifikan (P>0,05). Pemeriksaan serum pada babi (Sus scrofa) terhadap konsentrasi IL-6 kelompok perlakuan implan Zn-0,5Al dan ZnMg(4x) tidak menunjukkan perbedaan nyata (P>0,05) pada hari ke-0, 14, dan 28.
Co-Authors . Herlina Aditia Dwi Cahyono Agus Wijaya Agus Wijaya Ali Hujarat Anita Esfandiari April Hari Wardhana Aulia Andi Mustika Azzahrah, Putri Bayu Febram Bayu Firmala Kusuma Beata LYL Ayu Chusnul Choliq Deni Noviana Deny Setyo Wibowo Dewi, Fitriya Nur Annisa Dodi Darmakusuma Dondin Sajuthi Effendi, Siti Aisyah Rahmalia Erni Sulistiawati Esti Dhamayanti Fitri, Arni Diana Gunanti . Hammada Raudlowi I Ketut Sutama I Putu Kompiang I wayan Teguh Wibawan IETJE WIENTARSIH Intan Khoirunnisa Irda Khaeriyah Jessica Anggun Safitri Joesoef, Jayusman Arsiyanti Kartjito, Nicolas Edward Christanto Khairita, Lia Laksamana , Vincentius Bryan Leni Maylina Lia Khairita Lina Noviyanti Sutardi Muhammad Bintang Nabila Latifa Hafizsha Ningtias, Putri Indah Novitasari , Dina Nuraliyu , Roro Iyaka Putri Indah Ningtias Putri Indah Ningtias Rahmawati Januar Retno Wulansari Riana Nurul Maulani Rizal Rahadian Ramdhany Rumlaklak, Yanse Yane Selma Laily Nur Afifah Setyo Widi Nugroho Setyo Widodo Setyo Widodo Shavrillia Inovanny Angesti Soesatyoratih, Roro Solinda, Gamelita Rizkawandi sri murtini . Suryono Tika Aryanti Wiwin Winarsih Wolo, Kathirina Beathrik Riwu Yanse Yanne Rumlaklak