Chemical Investigation and Antimicrobial Activity of Medicinal Plant Toddalia asiatica Lam

Wilmar Maarisit (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia Tomohon, Jl. Raya Talete II Kuranga Tomohon, P.O. Box 112, Tomohon 95441, South Sulawesi, Indonesia)
Misran Lawani (Department of Agricultural Product Technology, Faculty of Agriculture, Khairun University, Jl. Raya Kampus Unkhair Gambesi Ternate, Ternate 97719, North Maluku, Indonesia)

Indonesian Journal of Chemistry
Vol 20, No 5 (2020)

Medicinal plants have become important sources of natural products, which have been used in the development of therapeutic agents. Four new coumarins (1-4) have been isolated together with five known metabolites (5-9) from the medicinal plant T. asiatica. The structures of 1-9 were assigned based on their spectroscopic data. Compounds (1-9) inhibited the growth of the Gram-negative bacteria E. coli and Gram-positive bacteria S. aureus at a concentration of 25 and 50 μg/disc. Compounds (2-4) inhibited the phytopathogenic fungus C. cucurbitarum at 50 μg/disc.