Journal of Applied Pharmaceutical Research
Vol. 2 No. 4 (2014)

Development and characterization of surface solid dispersion of curcumin for solubility enhancement

Singh, Mahendra Vikram (Unknown)
Juyal, Divya (Unknown)
Singh, Vikram (Unknown)
Rawat, Geeta (Unknown)
Tiwari, Akhilesh (Unknown)

Article Info

Publish Date
16 Dec 2014

Abstract

Surface solid dispersion (SSD) of curcumin was developed and characterized with purview to overcome solubility hurdle in its pharmacokinetic and pharmacodynamic performance. SSDs were prepared by co-evaporation method using polyplasdone XL, croscarmelose sodium, and silicone dioxide and polyethlene glycol 6000 as carrier. The optimized SSD (F9) was characterized using FE-SEM and XRD as an analytical tool. The formulation of modified Curcumin shows better drug release profile as compared to the natural Curcumin. Formulation F9 released more than 90% of the loaded Curcumin within 30 minutes where marketed formulations shows 90% drug only after 60 minutes.

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Journal Info
Journal of Applied Pharmaceutical Research
Website

Abbrev

joapr

Publisher

Creative Pharma Assent

Subject

Medicine & Pharmacology

Description

Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, ...