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Divya Juyal, Divya
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Medicine & Pharmacology

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Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS Kumar, Amrendra; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol 2 No 4 (2014)
Publisher : Creative Pharma Assent

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Abstract

The extended release spheroids was Formulated using Ethyl Cellulose, Povidone and Triacetin as a Coating material and evaluated the effect of change in weight build up on drug release profile. Optimization of extended release coating by 19% build up of EC/PVP-K30 of formulation (F4), in which the formulation is formulated by Reservoir system and the drug release depends on coating thickness of EC/PVP-K30. As concentration of coating weight buildup increases. which increases the thickness of coating on the reservoir system hence release retarded and transformed into an extended release system. 
Design and in vitro evaluation of mouth dissolving tablets olanzapine Sharma, Vivek Kumar; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol 3 No 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

The purpose of this research was to design and evaluate the olanzapine fast dissolving tablets.  The variable formulation of Olanzapine having challenging methodology. Olanzapine practically insoluble in water so used different polymers and superdisintigrant to make formulation. Direct compression are most desired method for preparation of mouth dissolving tablets. The tablets were evaluated for disintegration and dissolution properties of the formulation. In formulation of mouth dissolving tablet evaluate the precompression parameter and post compression parameter and after evaluation found satisfactory
Naringin a potent antioxidant used as bioavailibility enhancer for terbinafine hydrochloride Singh, Akanksha; Juyal, Divya; Singh, Vikram; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol 2 No 3 (2014)
Publisher : Creative Pharma Assent

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Abstract

The poor bioavailability of drugs has been identified as the single most important challenge in oral drug delivery. Prominent among the factors responsible for this are the oxidative metabolic activity of the intestinal and hepatic cytochrome P450 enzyme family. Naringin and naringenin which are the major phytochemical component of grapefruit juice, a well-known cytochrome P450 3A4 inhibitor and flavone glycoside, is antioxidant in nature and occurs naturally in the pericarp of citrus fruit, and particularly of grapefruit (Citrus paradisii) where it is the predominant flavonoid found and is responsible for the bitter taste associated with the fruit. CYP3A4 which is a class of CYP – 450 (microsomal enzyme) is responsible for the oxidative metabolic reaction of various substrates which decreases the bioavailability of drug. 
A review on solid dispersion: a modern formulation approach in drug delivery system Gupta, Dheeraj Kumar; Negi, Ritu; Kala, Shivani; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol 2 No 4 (2014)
Publisher : Creative Pharma Assent

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Abstract

Drugs those are given as solid dosage form and having low solubility often have a lack of flexibility in drug formulation and administration. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Solid dispersion technologies are promising techniques for improving the water solubility, and hence dissolution and bioavailability of hydrophobic drugs. It is done for Biopharmaceutical Classification System (BCS) II Class drugs. Solid dispersion is the dispersion of one or more active ingredients in hydrophilic inert carrier matrix at molecular level. Solid dispersions of poorly water-soluble drugs with water-soluble carriers have been reduced the incidence of these problems and enhanced dissolution. The focus of this review article is on advantages, disadvantages and the method of preparation, and characterization of the solid dispersion. This review also discusses the recent advances in the field of solid dispersion technology.
Solubility enhancement of biperidine hcl by complexation with hydroxypropyl β-cyclodextrin Dubey, Amit; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol 3 No 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Oral route is the simplest and easiest way of drug administration, because of the greater stability, lesser bulk, and cheap cost of production, accurate dosage and easy process, solid oral dosage forms have several advantages over other dosage forms. All the poor water soluble drugs after oral administrations are not well absorbed and thus leads to decrease in inherent efficiency of drugs. Therefore, for oral drug delivery system the improvement of drug solubility thereby its oral bio-availability is the most important aspect of drug development process. Biperiden HCl is a potent drug (Maximum daily dose is 16mg/day), having extensive first pass metabolism resulting in poor Bioavailability. The pharmacokinetic profile of this drug showed 33±5 % Bioavailability and 18-24 hours elimination half-life (t1/2). In the present study attempt has been made to prepare and characterize inclusion complex of Biperiden HCl with Hydroxypropyl β-Cyclodextrin. The inclusion complexes prepared by different methods i.e. Physical mixture, Kneading and Solvent evaporation methods. The prepared complexes were characterized using FT-IR. The inclusion complex prepared by Kneading method exhibited greatest enhancing in solubility and faster dissolution (93.98% drug release in 60 min) of Biperiden HCl.
Development and characterization of surface solid dispersion of curcumin for solubility enhancement Singh, Mahendra Vikram; Juyal, Divya; Singh, Vikram; Rawat, Geeta; Tiwari, Akhilesh
Journal of Applied Pharmaceutical Research Vol 2 No 4 (2014)
Publisher : Creative Pharma Assent

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Abstract

Surface solid dispersion (SSD) of curcumin was developed and characterized with purview to overcome solubility hurdle in its pharmacokinetic and pharmacodynamic performance. SSDs were prepared by co-evaporation method using polyplasdone XL, croscarmelose sodium, and silicone dioxide and polyethlene glycol 6000 as carrier. The optimized SSD (F9) was characterized using FE-SEM and XRD as an analytical tool. The formulation of modified Curcumin shows better drug release profile as compared to the natural Curcumin. Formulation F9 released more than 90% of the loaded Curcumin within 30 minutes where marketed formulations shows 90% drug only after 60 minutes.  
Naringin a potent antioxidant used as bioavailibility enhancer for terbinafine hydrochloride Singh, Akanksha; Juyal, Divya; Singh, Vikram; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol. 2 No. 3 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (750.5 KB)

Abstract

The poor bioavailability of drugs has been identified as the single most important challenge in oral drug delivery. Prominent among the factors responsible for this are the oxidative metabolic activity of the intestinal and hepatic cytochrome P450 enzyme family. Naringin and naringenin which are the major phytochemical component of grapefruit juice, a well-known cytochrome P450 3A4 inhibitor and flavone glycoside, is antioxidant in nature and occurs naturally in the pericarp of citrus fruit, and particularly of grapefruit (Citrus paradisii) where it is the predominant flavonoid found and is responsible for the bitter taste associated with the fruit. CYP3A4 which is a class of CYP – 450 (microsomal enzyme) is responsible for the oxidative metabolic reaction of various substrates which decreases the bioavailability of drug.
Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS Kumar, Amrendra; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol. 2 No. 4 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (183.496 KB)

Abstract

The extended release spheroids was Formulated using Ethyl Cellulose, Povidone and Triacetin as a Coating material and evaluated the effect of change in weight build up on drug release profile. Optimization of extended release coating by 19% build up of EC/PVP-K30 of formulation (F4), in which the formulation is formulated by Reservoir system and the drug release depends on coating thickness of EC/PVP-K30. As concentration of coating weight buildup increases. which increases the thickness of coating on the reservoir system hence release retarded and transformed into an extended release system.
Development and characterization of surface solid dispersion of curcumin for solubility enhancement Singh, Mahendra Vikram; Juyal, Divya; Singh, Vikram; Rawat, Geeta; Tiwari, Akhilesh
Journal of Applied Pharmaceutical Research Vol. 2 No. 4 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.571 KB)

Abstract

Surface solid dispersion (SSD) of curcumin was developed and characterized with purview to overcome solubility hurdle in its pharmacokinetic and pharmacodynamic performance. SSDs were prepared by co-evaporation method using polyplasdone XL, croscarmelose sodium, and silicone dioxide and polyethlene glycol 6000 as carrier. The optimized SSD (F9) was characterized using FE-SEM and XRD as an analytical tool. The formulation of modified Curcumin shows better drug release profile as compared to the natural Curcumin. Formulation F9 released more than 90% of the loaded Curcumin within 30 minutes where marketed formulations shows 90% drug only after 60 minutes.
A review on solid dispersion: a modern formulation approach in drug delivery system Gupta, Dheeraj Kumar; Negi, Ritu; Kala, Shivani; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol. 2 No. 4 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (422.131 KB)

Abstract

Drugs those are given as solid dosage form and having low solubility often have a lack of flexibility in drug formulation and administration. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Solid dispersion technologies are promising techniques for improving the water solubility, and hence dissolution and bioavailability of hydrophobic drugs. It is done for Biopharmaceutical Classification System (BCS) II Class drugs. Solid dispersion is the dispersion of one or more active ingredients in hydrophilic inert carrier matrix at molecular level. Solid dispersions of poorly water-soluble drugs with water-soluble carriers have been reduced the incidence of these problems and enhanced dissolution. The focus of this review article is on advantages, disadvantages and the method of preparation, and characterization of the solid dispersion. This review also discusses the recent advances in the field of solid dispersion technology.
Co-Authors Akanksha Singh, Akanksha Akhilesh Tiwari, Akhilesh Amit Dubey, Amit Amrendra Kumar, Amrendra Dheeraj Kumar Gupta, Dheeraj Kumar Geeta Rawat, Geeta Mahendra Vikram Singh, Mahendra Vikram Rawat, Geet Ritu Negi, Ritu Shivani Kala, Shivani Vikram Singh, Vikram Vivek Kumar Sharma, Vivek Kumar