Indonesian Journal of Pharmaceutical and Clinical Research
Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research

Teratogenic Effects of Arabica Coffee (Coffea arabica L) on Rats During the Organogenesis Period

Reza Destri Anggi (Unknown)
Yuandani (Unknown)
Dalimunthe, Aminah (Unknown)

Article Info

Publish Date
14 Jan 2021

Abstract

The purpose of the research was to evaluate the teratogenic effect caused by theprovision of Arabica coffee solution with variations of 0.36 ml, 0.72 ml and 1.08 ml withpositive control of caffeine at a dose of 300 mg / kg bw to rats during organogenesis. Themeasurement parameters in this study are the appearance of reproduction, externalmalformations and scalal malformations. The results in this study found that theadministration of Arabica coffee solution with a volume of 1.08 ml and caffeine 300 mg /kg bb caused an abnormality in the reproductive appearance of weight loss and body length,whereas for extrenal malformation and scalal malforation no abnormalities were found ineach administration of the solution Arabica coffee and caffeine.  

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Journal Info
Indonesian Journal of Pharmaceutical and Clinical Research
Website

Abbrev

idjpcr

Publisher

Universitas Sumatera Utara

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) is a-peer-reviewed publication of original research works. The mission of the journal is to offer a medium to exchange ideas and information about the advancement of knowledge and research in disciplines of pharmaceutical ...