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Yuandani
Department Of Pharmacology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
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STIMULASI WIRAUSAHA PADA MURID SEKOLAH MENENGAH ATAS DI TANJUNG PURA LANGKAT SUMATERA UTARA MELALUI WORKSHOP PEMBUATAN LOSION ANTI NYAMUK BERBASIS HERBAL Yuandani1; Marianne; Popi Patilaya
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 1 (2017): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (603.86 KB) | DOI: 10.32734/abdimastalenta.v2i1.2205

Abstract

SMA N 1 Tanjung Pura dan SMA Swasta Samanhudi terletak di kecamatan Tanjung Pura, Kabupaten Langkat, Provinsi Sumatera Utara. Kecamatan Tanjung Pura di Kabupaten Langkat merupakan salah satu kecamatan dengan tingkat kesejahteraan yang belum memadai. Sebahagian besar masyarakat bekerja sebagai petani dan nelayan, dan umumnya mereka belum dapat memenuhi biaya hidup yang memadai dan gagal dalam menguasai potensi produktif yang tersedia. Salah satu cara yang dapat dilakukan adalah diversifikasi pekerjaan dengan menstimulasi jiwa wirausaha generasi muda di Tanjung Pura, antara lain dengan memberikan keterampilan khusus yang nantinya bisa dimanfaatkan oleh mereka untuk membuka usaha sendiri. Salah satu cara yang akan dilakukan adalah dengan memberikan workshop pembuatan losion anti nyamuk. Hal ini mengingat kecamatan Tanjung Pura memiliki prevalensi yang tinggi terhadap penyakit malaria dan demam berdarah dengue (DBD), sehingga sangat tepat untuk mengajarkan para siswa SMA dalam pembuatan losion anti nyamuk agar dapat turut serta menurunkan angka kejadian penyakit tersebut. Oleh sebab itu,tujuan umum program pengabdian pada masyarakat ini adalah meningkatkan minat berwirausaha pada murid sekolah menengah atas, menurunkan angka pengangguran dan angka penyebaran penyakit malaria dan DBD di Kecamatan Tanjung Pura. Target utama dari program ini adalah sekelompok masyarakat yang memiliki latar pendidikan terakhir golongan menengah atau setara yang berada di Kecamatan Tanjung Pura. Secara khusus, program ini bertujuan untuk melatih siswa-siswi setingkat SMA yang ada di SMAN 1 Tanjung Pura dan SMA Swasta Samanhudi dalam berwirausaha untuk memproduksi losion anti nyamuk yang berbahan dasar minyak sereh.
Uji Aktivitas Antikanker (Preventif dan Kuratif) Ekstrak Etanol Temu Mangga (Curcuma Mangga Val.) Pada Mencit yang Diinduksi Siklofosfamid Yuandani, Yuandani; Dalimunthe, Aminah; Anjelisa Z. Hsb, Poppy; Wira Septama, Abdi
Majalah Kesehatan Pharmamedika Vol 3, No 2 (2011): JULI - DESEMBER 2011
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v3i2.443

Abstract

Prevalensi kanker di Indonesia cukup tinggi, menurut data Riset Kesehatan Dasar (Riskesdas) tahun 2007 terdapat  4,3 per 1000 penduduk menderita kanker. Sementara itu umumnya antineoplastik yang digunakan untuk pengobatan kanker menyebabkan toksisitas karena kerjanya yang kurang selektif. Oleh karena itu diperlukan penemuan obat baru dari tanaman sebagai alternatif pengobatan yang efektif dan aman.  Penelitian ini dimaksudkan untuk membuktikan adanya aktivitas antikanker ekstrak etanol rimpang temu mangga baik sebagai agen preventif maupun kuratif. Penelitian dilakukan dengan metode eksperimental menggunakan mencit jantan sehat, dengan berat badan 20 – 30 g sebagai hewan percobaan. Ekstrak etanol rimpang temu mangga  diberikan kepada hewan uji dengan dosis 200, 400, dan 800 mg/kg BB. Pada uji antikanker sebagai agen preventif diberikan sediaan uji tersebut selama 7 hari, pada hari ke-8 diinduksi siklofosfamid secara parenteral. Tigapuluh jam kemudian hewan dibunuh dan dibedah. Darah  diambil  untuk penentuan nilai hematokrit dan sumsum tulang femur untuk pemeriksaan mikronukleusambil. Sedangkan pada uji antikanker sebagai agen kuratif hewan dinduksi siklofosfamid terlebih dahulu, 30 jam kemudian diberi sediaan uji selama 7 hari. Pada hari ke-8  hewan dibunuh dan dibedah, lalu diambil darah untuk penentuan nilai hematokrit dan sumsum tulang femur pemeriksaan mikronukleusambil. Berdasarkan hasil penelitian diketahui rimpang temu mangga menghambat pembentukan mikronukleus dan meningkatkan nilai hematokrit baik pada uji preventif maupun kuratif yang bermakna secara statistik (P0,05). Aktivitas terbaik tampak pada dosis 800 mg/kg BB dengan jumlah mikronukleus dan nilai hematokrit yang mendekati nilai pada kelompok yang diberi suspensi CMC 1%. Hasil penelitian disimpulkan bahwa ekstrak etanol rimpang temu mangga memiliki aktivitas antikanker baik sebagai agen preventif maupun kuratif.
Antifungal Activity of Patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers Carriers against Trichophyton rubrum and Pitysporum ovale Ginting, Junius Gian; Hasibuan, Poppy Anjelisa Zaitun; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 2 (2021): Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) Vol. 04, No
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i2.6295

Abstract

Abstract. Wounds that are not treated and are kept open will provide an entrance for microorganisms from outside that can cause infection. One of the medical needs whose demand continues to increase is wound dressings. Chitosan is known to have wound healing activity by stimulating the formation of new tissue, and silver nanoparticles have good antimicrobial activity. Silver nanoparticles and chitosan with cellulose nanofibers carrier are made in the form of patches with the ratio formula between cellulose nanofibers and chitosan/silver nanoparticles are 1:9, 2:8, 3:8, 4:7, 5:5, 6:4, 7:3, 8:2, 9:1, and 10:0 then tested the antifungal activity against Trichophyton rubrum and Pitysporum ovale for finding the best formula for antifungal activity. The analysis showed that the patch with a ratio of 6:4 had the best antifungal activity against Trichophyton rubrum (14.7±0.1 mm) and a 9:1 patch on the Pitysporum ovale (6.9±0.05 mm) gave a significant difference to negative control (p<0.05). It can be concluded that the Patches Silver Nanoparticle and Chitosan with Cellulose Nanofibers (SNCCN) carriers have good antifungal activity in the inhibitory category.
ANTIDIABETIC ACTIVITY FROM ETHANOL EXTRACT OF KLUWIH’S LEAF (Artocarpus camansi) Marianne Marianne; Yuandani Yuandani; Rosnani Rosnani
Jurnal Natural Volume 11, Number 2, September 2011
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.426 KB)

Abstract

Research on antidiabetic activity of ethanol leaf extracts Kluwih (Artocarpus camansi) has been carried out to determine the antidiabetic activity of ethanol extract of leaves kluwih (EELK) of mice using glucose tolerance test. The study began by dividing the mice into 6 groups. Group 1 was given 1% CMC, group 2 to group 4, given EELK 50, 100, 200, 400 mg / kg bw, respectively, and group 6  administered with glibenclamide 0.45 mg/kg bw. Thirty minutes later each group was given glucose 30 mg/kg bw. After 30 min of glucose loading, blood glucose levels of mice were measured, and measured again at minute 60, 90, 120 and 150 minutes. The results showed that the glucose tolerance test EELK a significant effect in lowering blood glucose levels compared to controls at 30 and 60 minutes after administration of glucose. At minute 90 to 150, the effect of blood glucose levels EELK restore back to normal. EELK demonstrated ability to reduce blood glucose levels, and EELK doses of 50 and 100 mg/kg bw showed antidiabetic effects better than a dose of 200 and 400 mg/kg bw. Increasing doses showed antagonistic effects: the ability to increase blood glucose levels.
Immunomodulatory Effects of Phaleria macrocarpa Leaf Extract in Normal And Cyclophosphamides Induced in Wistar Rats Febriady, Andy; Harahap, Urip; Yuandani, Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.11271

Abstract

Abstract. Cyclophosphamide is an antineoplastic drug belonging to the alkylating agents commonly used in treating cancer. However, the use of cyclophosphamide causes a decrease in the body's immune system by reducing lymphocyte proliferation. The curent study was conducted to evaluate the immunomodulatory effect of ethyl acetate extracts of the leaf of the P. macrocarpa (EEADMD) and the ethanol extracts of the leaf of the P. macrocarpa (EEDMD) in normal and cyclophosphamide induced rats. This study used rats classified into two major groups: normal rats and rats induced by cyclophosphamide which were then given P. macrocarpa leaf extract until day 14. On day 4, the test animals were infected with 1% Staphylococcus aureus suspension in. Induced with cyclophosphamide 70 mg/kg BW was carried out on the 8th and 13th days, and then the immunomodulatory activity was tested using total leukocyte analysis, leukocyte differential, and delayed type hypersensitivity response. The results showed that EEDMD 400 mg/kg BW  in normal rats and EEDMD 100 mg/kg BW in cyclophosphamide induced rats could increase total leukocytes and leukocyte differential with a significant difference to the negative group (p <0.05). The results of the delayed hypersensitivity response test of EEADMD and EEDMD at a dose of 100 mg/kg BW with cyclophosphamide induction and normal rats could give an increase in rat paw volume with a significant difference to the negative group (p <0.05). This study shows that EEADMD and EEDMD have an immunomodulatory effect on increasing total and differential leukocytes and leukocyte differential and delayed type hypersensitivity response.
Immunomodulator Activity Test of Curucuminoid Extract Derived from Turmeric Rhizome (Curcuma domestica Val.) In VCO On Rats Injected with Staphylococcus aureus Against an Increase in The Concentration of Leucocyte and Its Components. Pratiwi, Indah; Yuandani; Putra, Effendy De Lux; Satria, Denny
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.905

Abstract

One of the medicinal Zingiberaceae plants which is regularly used by the society as a traditional remedy is turmeric rhizome. The pharmacological properties of turmeric rhizome include anti-inflammatory, anti-immunodeficiency, anti-viral. Anti-bacterial, anti-fungal, anti-oxidant, anti-carcinogenic, and anti-infectious. This study aimed to identify the immunomodulator activity of curcuminoid extract of turmeric rhizome against the increase of leucocyte and its components, lymphocyte and neutrophil in white Galur Wistar rats that had been injected with Staphylococcus aureus. These test animals were given curcuminoid extract in VCO 100 mg/ml on a dosage of 1 ml, 0,5 ml, 0,25 ml curcuminoid powder 200 mg/kg body weight. Curcuminoid was suspended in Na CMC0,5%, Levamisole 25 mg/kg of body weight suspended in Na CMC 0,5%, VCO 1 ml. For the negative control, merely Na CMC 0,5% was given. The extract was orally given daily for 14 days. On the 4th day, Staphylococcus aureus was injected intra-peritoneally. The rats’ blood was then drawn from the heart and was observed to calculate the volume of the leucocytes, lymphocyte, and neutrophil which was conducted using flow cytometry.The findings suggested that there was a significant difference between the immunomodulatory activity of the curcuminoid extract in VCO at the doses of 1 ml, 0,5 ml, 0,25 ml on the increase in leucocyte, lymphocyte, and neutrophil compared to that of the negative control.Therefore, the findings of this study indicated that the extracts of curcuminoid in VCO could increase the number of leucocytes, lymphocytes, and neutrophils. Thus, the curcuminoid extract of turmeric rhizome in VCO potentially possessed immunomodulatory activity.
Synergistic Antibacterial Activity of Curcuma domestica Val. Extract with Tetracycline Against Multidrug-resistant Acinetobacter baumannii Nasution, Halimah Raina; Yuandani, Yuandani; Septama, Abdi Wira; Nugraha, Sony Eka; Sufitni, Sufitni; Khairunnisa, Nur Aini
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.8593

Abstract

Infections caused by multidrug-resistant (MDR) bacteria are on the rise globally. MDR is facilitated by overexpression of efflux pump and permeability changes of membrane. Acinetobacter baumannii is a pathogenic germ that causes a major problem in infection, also, there has been an increase in the incidence of resistance to various antibiotics. The present study highlights the synergistic of ethanolic extract of Curcuma domestica (EECD) rhizome with tetracycline against multidrug-resistant A. baumannii (MDR-Ab). Assessment of Minimum Inhibitory Concentration (MIC) was determined by microdilution using 96-well plates. The synergistic effect of EECD and tetracycline was determined by checkerboard method. The effect of EECD and tetracycline combination was investigated by bacteriolytic activity and inhibition of efflux pump by Ethidium Bromide (EtBr) accumulation assay. EECD presented the MIC value 250 µg/mL against MDR-Ab. Fractional Inhibitory Concentration Index (FICI) value of EECD and tetracycline combination was 0.4, which showed their synergistic effect. Additionally, the combination of EECD and tetracycline could inhibit the efflux pump in MDR-Ab. This combination can also compromise cell integrity by altering membrane permeability thus lysing the bacteria cells. According to these results, EECD and tetracycline combination has synergistic effects at some sites of action, and thus could be used as a breakthrough to overcome infection problems due to MDR-Ab. Keywords: Acinetobacter baumannii, antibacterial, Curcuma domestica, multidrug-resistant, tetracycline
Immunomodulatory Effects of Ethanol Extract of Lime Peel on Phagocytosis Activity and Delayed-Type Hypersensitivity Response Amanda, Safina Audiva; Yuandani, Yuandani
Journal La Medihealtico Vol. 5 No. 2 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i2.1249

Abstract

The natural human environment is inhabited by various organisms, including those harmful to the body such as bacteria, viruses, fungi, and other pathogens. This condition weakens the immune system's response to pathogens, making the body more susceptible to diseases such as rheumatoid arthritis, cancer, and other inflammations. In some cases, this condition can be fatal, leading to death. This study aims to examine the immunomodulatory effects of Ethanol Extract of Lime Peel on phagocytosis activity and delayed-type hypersensitivity response in experimental animals. The research methods include sample collection and processing, plant identification, extract preparation, and immunomodulatory effect testing. Phytochemical screening results showed the presence of alkaloids, glycosides, flavonoids, tannins, and steroids in the extract of the lime peel. Simplicia and ethanol extract of lime peel characterization yielded results meet the standards of the Indonesian Herbal Pharmacopoeia 2nd edition. Immunomodulatory effect testing was conducted through phagocytosis activity and delayed-type hypersensitivity response assays. The results showed that the extract at doses of 25, 50, and 100 mg/kgBW had immunostimulatory effects in enhancing phagocytosis activity, while doses of 17.5 mg/kgBW, 35 mg/kgBW, and 70 mg/kgBW significantly increased delayed-type hypersensitivity response compared to the negative control. These findings indicate the potential of ethanol extract of Citrus aurantifolia as an immunomodulator that can enhance the body's immune system. This study provides an important contribution to the development of immunomodulatory therapy derived from natural ingredients such as lime peel for managing immunity-related diseases with lower side effects.
Effectiveness of Banana Leaves (Musa Paradisiaca L) as A Bandage for Healing Diabetes Wounds Simamora, Hengky; Tanjung, Dudut; Yuandani, Yuandani
Indonesian Journal of Global Health Research Vol 6 No 6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i6.4410

Abstract

Diabetes mellitus is a chronic degenerative disease characterized by increased blood glucose levels that exceed normal limits. Complications often experienced by patients with diabetes mellitus are wounds. Wounds that are difficult to heal can result in amputation. Banana leaves have antioxidant activity and biological functions including anti-diabetic and have been proven to be a source of bioactive compounds that function to stop or inhibit the growth of bacteria and fungi that can cause infection in wound tissue. Objective: to analyze the effectiveness of banana leaves as a dressing in the wound healing process in diabetic patients. The study was a quasi-experiment with a pre-post control design. Thirty-two were applied in this study, 16 were intervention group and 16 were control group. Data were collected using the Bates-Jensen Wound Assessment Tool and analyzed using the Wilcoxon signed-rank test. There is a significant difference in wound healing in the intervention group before and after the use of banana leaves as a dressing (p<0.001). The results of this study can be a basis for nurses in applying or implementing banana leaves as wound dressings for the healing process of diabetic wounds, both chronic and acute wounds, and these results can support nurses in carrying out independent nursing care.
Hepatoprotective Activity of Curcuma mangga Extract on Paracetamol-Induced Male Mice Yuandani; Mardaliza, Silvia; Marianne
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 2 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (715.476 KB) | DOI: 10.32734/idjpcr.v1i2.432

Abstract

This study was carried out to investigate the protective effect of ethanol extract of Curcuma mangga rhizomes on paracetamol-induced hepatotoxicity. High dose of paracetamol (1.35g/kg bw) was used to induce hepatic necrosis of mice liver. The male mice received ethanol extract of C. mangga rhizomes (100, 200 and 400 mg/kg BW) for 7 days. The hepatoprotective actvity of extract was compared to normal, positive (curcuma) and negative control. The liver function was evaluated by measuring the biochemistry parameters which include alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In addition, histophatological study on hepatic tissue section was also carried out. The C. mangga extract displayed hepatoprotective effect except at dose of 100 mg/kg bw. The increasing of serum levels of AST and ALT were inhibited after treatment with ethanol extract at doses of 200 and 400 mg/kb bw which was comparable with normal and curcuma as postive control (p>0.05). In addition, histological assessment of hepatic tissue demonstrated no liver damage, specially at dose of 400 mg/kb BW. The result indicate that ethanol extract of C. mangga rhizomes has hepatoprotective effect, especially at doses of 200 and 400 mg/kg bw . Keywords: C. mangga, rhizomes, biochemistry parameters, histopathology
Co-Authors . Marianne Abdi Wira Septama Abdi Wira Septama Amanda, Safina Audiva Aminah Dalimunthe Anggreini, Dea Anjelisa Z. Hsb, Poppy BANGUN, HERIANTO Berkat Waruwu, Syukur Damayanti Damayanti Denny Satria, Denny Dudut Tanjung Effendy De Lux Putra, Effendy De Lux Eka Nugraha, Sony El Farhani Hasti Habibi Samosir, Fauziah Emil Salim Febriady, Andy Gaol, Budianto Lumban Ginting, Junius Gian Glorya Sihaloho, Angelica Hafid Syahputra Hanna Magdalena Simangunsong, Irene Hanum, Tengku Ismanelly HARI PURNOMO Hasibuan, Poppy Anjelisa Zaitun Indah Pratiwi Julianti, Maelani Khairunnisa, Nur Aini Kusuma Danny, Faustina Lumban Gaol, Nurahmi Mardaliza, Silvia Marianne Marianne Muhammad Yunus Nabila, Nabila Naja Sakinah, Thara Nasution, Halimah Raina Ningtias, Anggitha Pebrian Siregar, Jonathan Popi Patilaya Prayoga, Andre Reza Destri Anggi Rezza Fikrih Utama Rosidah Rosnani Rosnani Simamora, Hengky Simanjuntak, Nerly Juli Pranita Siti Morin Sinaga Sitorus, Panal Sufitni Syafitri, Anggun Tree Sabina, Fani Tri Widyawati, Tri Try Nursylla, Rantyta Urip Harahap Wira Septama, Abdi Wiraseptama, Abdi Wiryanto Yulia Fitri Ziza Putri Aisyia Fauzi