EFEK PEMBERIAN REBUSAN KULIT MARKISA UNGU (PASSIFLORA EDULIS) SEBAGAI ANTIDIABETIK TERHADAP GAMBARAN HISTOPATOLOGI PANKREAS TIKUS YANG DIINDUKSI STREPTOZOTOSIN

USWATUL KHOIROT (UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA)
EMNI PURWONINGSIH (UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA)
HUMAIRAH MEDINA LIZA LUBIS (UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA)
LITA SEPTINA (UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA)

JURNAL ILMIAH KOHESI
Vol 5 No 1 (2021): JURNAL ILMIAH KOHESI

DM is one of the greatest health problems around the world. Nowdays, we found many studies proved many plants whichcontain antioxidant have a potential as antidiabetic. Antioxidants are able to repair oxidative stress in pancreatic beta cellsthat overcome pancreatic tissues damage. One of the plant that contains rich antioxidant is purple passion fruit ( Passifloraeduils). This study used True Experimental method, with Post –Test Only Control Group Design, which only gave anobservation to a control group after being given a treatment. The sample of this study was white Wister strain male rats(Rattus Norvegisus L). The statistic study of this research used Kruskal Wallis and Mann-Whitney with a significance level ofp > 0,05, because the data were not normally distributed. Pancreatic histopathology improvement in the first treatment groupshowed a non-significant difference compared with positive controlled group (p< 0, 05). Pancreatic histopathologyimprovement in the second treatment group showed a significant different compared with positive controlled group(p< 0, 05). There was an effect of giving purple passion fruit skin decoction (Passiflora eduils) as anti-diabetic to the ratpancreas histopathology that inducted by streptozotosin.