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All Journal Indonesian Journal of Pharmaceutical Science and Technology Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran dan Kesehatan JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Hasil Pengabdian Kepada Masyarakat Jurnal Aisyah : Jurnal Ilmu Kesehatan JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Budapest International Research in Exact Sciences (BirEx Journal) Jurnal Implementa Husada ABDI SABHA (Jurnal Pengabdian kepada Masyarakat) DedikasiMU: Journal of Community Service Empowerment: Jurnal Pengabdian Masyarakat Indonesian Journal of Cancer Jurnal Salingka Abdimas Eduvest - Journal of Universal Studies PROSIDING SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT (SNPPM) UNIVERSITAS MUHAMMADIYAH METRO Jurnal Pandu Husada
Humairah Medina Liza Lubis
Universitas Muhammadiyah Sumatera Utara
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CROHN DISEASE Lubis, Humairah Medina Liza
JURNAL IBNU SINA BIOMEDIKA Vol 1, No 2 (2017)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (780.395 KB) | DOI: 10.30596/isb.v1i2.1651

Abstract

Crohn disease merupakan salah satu dari idiopathic inflammatory bowel disease disamping ulcerative colitis. Crohn disease, dikenal juga dengan granulomatous colitis, regional enteritis dan terminal ileitis adalah penyakit autoimun yang melibatkan banyak area dari traktus gastrointestinal mulai dari esofagus hingga anus, tetapi kebanyakan melibatkan small intestine (ileum terminalis) dan kolon, biasanya multifokal. Gejala khas nyeri abdomen flare up, berulang, mereda dan bersifat kronis. Didapatkan satu kasus Crohn Disease pada seorang wanita berusia 52 tahun dengan keluhan nyeri perut seperti disayat pisau yang telah dialaminya selama 1 tahun. Dari hasil mikroskopik didapatkan gambaran yang mendukung suatu lesi Crohn disease.
PENGARUH PEMBERIAN EKSTRAK BUAH PARE (MOMORDICA CHARANTIA) TERHADAP GAMBARAN HISTOPATOLOGI ORGAN TRAKEA PADA TIKUS WISTAR YANG DIINDUKSI OBAT NYAMUK BAKAR Utami, Tania Mulia; Lubis, Humairah Medina Liza; Delyuzar, Delyuzar; Sutysna, Hendra
JURNAL IBNU SINA BIOMEDIKA Vol 2, No 1 (2018)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (564.5 KB) | DOI: 10.30596/isb.v2i1.1907

Abstract

Background: indonesia is a tropical country and has two seasons, there are summer and rainy season. This condition will  increase the population of mosquito especially in transition period. The producer of insect-repellent use this opportunity to make mospuito coil. In fact, mosquito coil is dangerous for the healthy of trachea. There are many herbs has been investigated, including pare, because it contains antioxidant. Objective: This experiment is about the effect of pare’s extract (Momordica charantia) in  histopathology of trachea in wistar mouse which is induced by mosquito coil. Method : laboratoric experiment with posttest only with control group design. Mouses divide into 4 groups and will be treat for 30 days. After that, the extract will be given in250mg/bw and500mg/bw. This experiment will examine the histopathology of trachea with HE and  light microscope. The data will be analyzed with Kruskal-wallis post Hoc Mann-Whitney. Result: there are significant diffrentiation  in degeneration, metaplasia, necrosis, and mucose thickening score in experiment and control group. Giving 250mg/bw and 500mg/bw of pare’s extract show improvement in trachea tissue. Conclusion: giving mosquito coil can induce the damage of trachea tissue with degeneration, metaplasia, necrosis and mucose thickening process. Giving pare’s extract as antioxidant show the improvement of trachea histopathologyKeywords: pare’s extract, mosquito coil, trachea histopathology, flavonoid.
UJI EFEKTIVITAS EKSTRAK DAUN LEMBAYUNG (Vigna unguiculata) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS DIABETES MELLITUS DENGAN INDUKSI ALOKSAN Afelita, Tia; Sari, Indah Permata; Zulkarnain, Rizki Chairani; Hasanah, Nurul; Lubita, Mardiyah; Lubis, Humairah Medina Liza
JURNAL IBNU SINA BIOMEDIKA Vol 1, No 1 (2017)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.427 KB) | DOI: 10.30596/isb.v1i1.1112

Abstract

Abstrak Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak dan lembayung terhadap kadar glukosa darah tikus putih yang diinduksi aloksan. Daun lembayung ini diketahui mengandung flavonoid yang mempunyai efek hipoglikemik.Penelitian ini bersifat eksperimental dan pre dan post group design. Hewan uji yang digunakan 20 ekor tikus putih jantan galur wistar dengan berat badan ±200 gram. Tikus putih dibagi dalam 4 kelompok masing-masing 5 ekor, yaitu, kelompok II sebagai kelompok positif (aloksan), kelompok III dan IV masing-masing diberikan ekstrak daun lembayung 3,6 mg/kgbb dan 7,2 mg/kgbb secara oral. Pengukuran kadar glukosa darah puasa tikus putih dilakukan pada hari pertama (sebelum pemberian aloksan), setelah pemberian aloksan, serta setelah pemberian perlakuan. Data yang diperoleh dianalisis dengan ANOVA dengan nilai p = 0,000. Hasil analisis uji Pos Hoc menunjukkan kelompok perlakuan pemberian ekstran daun lembayung memiliki perbedaan bermakna dengan kelompok kontrol. Hasil analisis uji T-Tes kelompok perlakuan menunjukkan perbedaan kadar glukosa darah yang signifikan antara sebelum dan setelah perlakuan. Abstrak Lembayung leaf extract contains flavonoids compound known as hypoglycemic agents. This research aimed to know the effect of lembayung leaf extract on the blood glucose in hyperglycemic white rad induced by alloxan.This was an experimental research with pre-end post-test design. The subjects were twenty wistar mal write rats selected by a simple random technique. They were divided into 4 groups, normal control group (Aquades group), positive control group (alloxan), and two group of lembayung leaf extract based on dose 3,6 mg/kgbb and 7,2 mg/kgbb. Blood glucose were measured in the first day as GDP1, after alloxan induced as GDP2, and the last, after treatment. The data were analyzed by Anova test followed by Post Hoc Test using SPSS.This research showed that there was significant difference between four groups p = 0,000 by Anova. All lembayung leaf extract group has significant difference with control group by Post Hoc Test. All treatment group has significant difference between pre- and post-test by T-TestKeywords : lembayung leaf extract, blood glucose, flavonoid 
Ekstrak Buah Legundi (Vitex trifolia) Mampu Menghambat Pembelahan dan Pertumbuhan Sel Tumor Kulit Tikus Lubis, Humairah Medina Liza; Hariaji, Ilham
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 17 No 1: January 2017
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dengan perubahan gaya hidup manusia yang tidak sehat, terpapar radiasi sinar ultraviolet, agen fisika dan kimia secara berlebihan, luka yang lama tidak sembuh khususnya luka bakar dan infeksi virus, yang apabila dibiarkan dan tidak diobati bisa berkembang menjadi kanker. Pengobatan untuk tumor lebih banyak menggunakan obat-obatan sintetik yang juga dapat menimbulkan komplikasi dan kebanyakan belum menunjukkan hasil yang memuaskan, sehingga banyak penelitian ditujukan pada tanaman tradisional yang banyak tumbuh di Indonesia. Tujuan penelitian ini adalah untuk mengetahui potensi penghambat pembelahan sel dari ekstrak buah legundi (Vitex trifolia). Penelitian ini adalah studi eksperimental dengan menggunakan tikus Wistar yang dibagi dalam 5 kelompok yaitu kelompok kontrol normal (K1), kontrol positif (K2), P1, P2, P3. Ekstrak etanol buah V. trifolia dibagi dalam 2 dosis yaitu 0,5g dan 1g/kgBB/hari/oral selama 3 minggu. Hasil penelitian berupa 3 slide (60%) adalah tumor ganas (nonkeratinizing squamous cellcarcinoma), 1 slide (20%) adalah lesi atipik dan 1 slide (20%) adalah lesi jinak. Setelah pemberian terapi menggunakan buah V. trifolia, kelompok 2, 3, dan 4 yang memiliki lesi tumor mengalami penurunan ukuran (mengecil). Disimpulkan bahwa ekstrak etanol buah V. trifolia memiliki kemampuan untuk menginhibisi aktivitas proliferasi dan pertumbuhan dengan dosis pemberian 0,5 g dan 1 gr/hari.
Effects of AntiMycobacterium Tuberculosis Nanoherbal Legundy Leaf Extract (Vitex trifolia) Dwiyanti, Atika; Mulyani, Siti; Yulhan, Oche Axena; Lubis, Humairah Medina Liza; Roslina, Ance
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 1: January 2021
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i1.6497

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Indonesia ranks 2nd largest in the world after India. Resistance to anti-tuberculosis drugs is one of the difficulties in treating tuberculosis. This research aim to determine the effectiveness of legundi (Vitex trifolia) leaf extract nanoherbal in killing Mycobacterium tuberculosis. This study was conducted with an experimental design using M. tuberculosis colonies taken from 25 samples of aspirate of tuberculosis patients with lymph nodes and then given the ethanol extract of legundi leaves (70% and 90%) with the process of making nanoparticle extracts. The evaluation of the observations was in the form of measuring the inhibition zone for bacterial growth which were categorized as weak ( 5mm), moderate (6-10mm), strong (11-20 mm) and very strong ( 21mm). The results of the study from 6 repetitions found that the inhibition zone category was 0% weak, 39% moderate, strong 52.3%, and very strong 8.7%. Comparison of the concentration of legundi leaf extract to the diameter of the bacterial growth inhibitory zone was analyzed using the Kruskal Wallis test, which found a significant relationship with p value = 0.000 ( 0.05). Legundi's leaf extract can be used as an antibacterial agent for M. tuberculosis. 
Ekstrak Buah Legundi (Vitex trifolia) Mampu Menghambat Pembelahan dan Pertumbuhan Sel Tumor Kulit Tikus Lubis, Humairah Medina Liza; Hariaji, Ilham
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 17, No 1 (2017): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v17i1.3676

Abstract

Dengan perubahan gaya hidup manusia yang tidak sehat, terpapar radiasi sinar ultraviolet, agen fisika dan kimia secara berlebihan, luka yang lama tidak sembuh khususnya luka bakar dan infeksi virus, yang apabila dibiarkan dan tidak diobati bisa berkembang menjadi kanker. Pengobatan untuk tumor lebih banyak menggunakan obat-obatan sintetik yang juga dapat menimbulkan komplikasi dan kebanyakan belum menunjukkan hasil yang memuaskan, sehingga banyak penelitian ditujukan pada tanaman tradisional yang banyak tumbuh di Indonesia. Tujuan penelitian ini adalah untuk mengetahui potensi penghambat pembelahan sel dari ekstrak buah legundi (Vitex trifolia). Penelitian ini adalah studi eksperimental dengan menggunakan tikus Wistar yang dibagi dalam 5 kelompok yaitu kelompok kontrol normal (K1), kontrol positif (K2), P1, P2, P3. Ekstrak etanol buah V. trifolia dibagi dalam 2 dosis yaitu 0,5g dan 1g/kgBB/hari/oral selama 3 minggu. Hasil penelitian berupa 3 slide (60%) adalah tumor ganas (nonkeratinizing squamous cellcarcinoma), 1 slide (20%) adalah lesi atipik dan 1 slide (20%) adalah lesi jinak. Setelah pemberian terapi menggunakan buah V. trifolia, kelompok 2, 3, dan 4 yang memiliki lesi tumor mengalami penurunan ukuran (mengecil). Disimpulkan bahwa ekstrak etanol buah V. trifolia memiliki kemampuan untuk menginhibisi aktivitas proliferasi dan pertumbuhan dengan dosis pemberian 0,5 g dan 1 gr/hari.
Effects of AntiMycobacterium Tuberculosis Nanoherbal Legundy Leaf Extract (Vitex trifolia) Atika Dwiyanti; Siti Mulyani; Oche Axena Yulhan; Humairah Medina Liza Lubis; Ance Roslina
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 1 (2021): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i1.6497

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Indonesia ranks 2nd largest in the world after India. Resistance to anti-tuberculosis drugs is one of the difficulties in treating tuberculosis. This research aim to determine the effectiveness of legundi (Vitex trifolia) leaf extract nanoherbal in killing Mycobacterium tuberculosis. This study was conducted with an experimental design using M. tuberculosis colonies taken from 25 samples of aspirate of tuberculosis patients with lymph nodes and then given the ethanol extract of legundi leaves (70% and 90%) with the process of making nanoparticle extracts. The evaluation of the observations was in the form of measuring the inhibition zone for bacterial growth which were categorized as weak (5mm), moderate (6-10mm), strong (11-20 mm) and very strong ( 21mm). The results of the study from 6 repetitions found that the inhibition zone category was 0% weak, 39% moderate, strong 52.3%, and very strong 8.7%. Comparison of the concentration of legundi leaf extract to the diameter of the bacterial growth inhibitory zone was analyzed using the Kruskal Wallis test, which found a significant relationship with p value = 0.000 (0.05). Legundi's leaf extract can be used as an antibacterial agent for M. tuberculosis. 
Immunocytochemical Study of Rabbit-Polyclonal to Mycobacterium Tuberculosis, AB905: Improving Diagnostic of Tuberculous Lymphadenitis Humairah Medina Liza Lubis; Emni Purwoningsih; Ance Roslina; Muhammad Al Anas
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 2 (2021): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i2.11559

Abstract

Tuberculous lymphadenitis (TBLN) is the most common form of extrapulmonary tuberculosis. However, the optimal diagnosis using Fine-Needle Aspiration Cytology (FNAC) or excisional biopsy is uncertain. This research aims to improve the diagnostic of TBLN with FNAC and immunocytochemistry (ICC) compared to the response to antituberculosis therapy. The cross-sectional study involved 43 patients with the criteria for TBLN diagnosis based on the appropriate clinical history of tuberculosis and indicative cytological results. Immunocytochemical examination employed rabbit-polyclonal to Mycobacterium tuberculosis (MTB) antibody (AB905). The MTB expression was found in 35 out of 43 cases (81%) that appropriate cytological features of the tuberculosis process. Meanwhile, eight out of 43 cases (19%) did not express MTB. Diagnostic tests for lesions with a positive cytologic appearance of TBLN and ICC were compared to the response to anti-tuberculosis therapy, revealing the sensitivity, specificity, positive predictive value, and negative predictive value of 95.2%, 75%, 95.2%, and 17%, respectively. Besides, Fisher's exact tests utilized to identify the relationship between two variables; p 0.05 was considered significant. This research found immunocytochemical study was a sensitive and specific tool for improving the diagnostic of TBLN.
PERBANDINGAN EFEKTIVITAS NEFROPROTEKTOR EKSTRAK JINTAN HITAM (NIGELLA SATIVA) DENGAN EKSTRAK TEMULAWAK (CURCUMA XANTHORRHIZA) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS (RATTUS NOVERGICUS) YANG DIINDUKSI PARASETAMOL KARTIKA HANDAYANI; DES SURYANI; HUMAIRAH MEDINA LIZA LUBIS
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Over-use of paracetamol can cause nephrotoxicity. Black cumin and curcuma contain antioxidants that can ward off freeradicals produced by paracetamol metabolism. To compare the effectiveness of nephroprotector of black cumin extract andcurcuma extract on the histopathological picture of rats induced by paracetamol. True experimental, Post Test Only ControlDesign. 24 rats were divided into 4 groups: negative control standard diet and aquades, positive group paracetamol dose500 mg / kgBB, treatment 1 extract of black cumin extract 500 mg / kgBB, and treatment 2 curcuma extract 500 mg / kgBB.After 30 minutes P1 and P2 were given a dose of paracetamol 500 mg / kg. Rats were dissected for kidney removal andhistopathological preparations were made. Degeneration, necrosis and bleeding of the proximal tubules were assessed byscoring, comparison of scores between groups was assessed by the kruskal wallis test. There were nephroprotector effectsof black cumin and curcuma, with the same effectiveness on kidney damage induced by paracetamol. Black cumin can bedeveloped further as a nephroprotector.
PREVALENSI DAN FAKTOR - FAKTOR YANG TERKAIT DENGAN PERKEMBANGAN KEJADIAN PENYAKIT TUBERKULOSIS MULTIDRUG RESISTANT DI KOTA MEDAN RIFQY IMSYA AL AYYUBI LUBIS; HUMAIRAH MEDINA LIZA LUBIS
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Multidrugs resistant tuberculosis is a type of TB bacterial resistance to at least two first-line anti-TB drugs, namely Isoniazidand Rifampin which are the two most effective TB drugs.1 A global total of 186,772 cases of MDR / RR-TB were detectedand known in 2018, up from 160,684 in 2017, 156,071 cases were registered in treatment, up from 139,140 in 2017. Theestimated incidence of drug-resistant TB cases in Indonesia was 24,000 in 2018, but in 2018 only 9180 TB RR patients werefound and only 49% of TB patients were confirmed. RR initiating second-line TB treatment. The aim of this study was tocollect data on the prevalence and factors associated with the development of the incidence of multidrug resistanttuberculosis in the city of Medan. This study was a descriptive analytic study with a cross section design. The researchsample consisted of 28 MDR TB patients at Puskesmas Helvetia and RSUD Pirngadi Medan, which were taken by totalsampling method. This study was tested with the Pearson correlation test. The results of this study showed that the riskfactors for the sample of this study were male gender 15 people (53.6%), mean age above 40 years 21 people (75.0%) 26people (92.9%) married status, 25 people with high school education level (89.3%), 9 self-employed people (32.1%), monthlyincome less than 1,000,000 15 people (53.6%), history of use Previous OAT OAT line 1 (complete) 11 people (39.3%), ahistory of smoking 14 people (50.0%), a history of not consuming alcohol 23 people (82.1%), patient knowledge about MDRTB was less or bad 18 people (53.6%), patient compliance in taking medicine was good 17 people (60.7%), 16 people wereless motivated to take medication (57.1%) and the patient's daily habits were good 14 people (50.0%). The relationshipbetween several risk factors such as previous drug use history with the level of patient adherence to MDR TB, the level ofmedication adherence and motivation to take medication and vice versa. meanwhile, daily habits such as smoking andalcohol consumption had no relationship with previous history of drug use, patient adherence to MDR TB, level of medicationadherence and motivation to take medication.
Co-Authors Afelita, Tia Afif Fadhilah Irsyad Afifah Endah Dwi Purianti Ainur Rofiq Ainur Rofiq Aisyah Salsabila Alamsyah, Tegar Alfarisi, Bunail Isna Amanda Farra Assyfah Aminuyati Amira Fazhira Ance Roslina ANNISA . ANNISA FITRI HENDEWI Annisa Rifqa Hestiana Annissa Ambaravista Nasution Atika Dwiyanti Atika Rahmi Atmaja, Pramudia Barasa, Neza Farach Addiba Berkah Tania Sawitri Bunail Isna Alfarisi Ceri Permata Ayuni Charisma Yani Roza Cindy, Tiara Safira Cindykia, Assyifa DEA YULIA LUBIS Delyuzar, Delyuzar Des Suryani Des Suryani DEWI AGUSTIN HAKIM HARAHAP Dilma Ayu Khairani DIWA AULIA AHMAD Dwiyanti, Atika Fadillah, Akram Fadlina, Shofiah Dina Fayyaza, Nesya Alya Filzah, Rahmah Fitri Nur Malini Frina Aeni Putri Galang Ramadhan Hasanah, Nurul HENDRA SUTYSNA Herian, M. Fauzan Alfatin Hervina, Hervina Hestiana, Annisa Rifqa Hidayatullah, Muhammad Rafli HSB, Fatur M Ahmad IBNU AFIF ARMADI Ilham Hariaji Indyra Mahrani Lubis Irsyad, Afif Fadhilah Islami, M. Dian Isnaini Ulfa Jamilah, Qurratu Kasturi KARTIKA HANDAYANI Kesuma, Ilham Jaya KHAIRATUL FITHRIYAH Kirana Arum Indra Laden Laden, Laden LITA SEPTINA Lubita, Mardiyah M. Dian Islami Malini, Fitri Nur MEIZLY ANDINA Muhammad Al Anas Muhammad Farouq Hilmi Harahap Muhammad Fathurridha Arabia Salim Muhammad Rafli Hidayatullah Muhammad Zikri Agung Ramadhan Muhammad Zulfikar Karim Chan Nasution, Annissa Ambaravista Nasution, Reyhan Khaira Helmita Nesya Alya Fayyaza Noviardy, Arya Nurcahaya Sinaga Nurfadly, Nurfadly Oche Axena Yulhan Purwoningsih, Emni Qatrunnada Medina Salim Qatrunnada Medina Salim Rafa Nabila Haifa Rafa Nabila Haifa Rahma Rifda F.S. Lubis Rahmah Filzah Raihana Zavira Ramadhan, Galang Ramadhan, Reza Mukti Ratih Yulistika Utami RIFQY IMSYA AL AYYUBI LUBIS Rizkitha Martono Putri Rizky Yusfasari Robitah Asfur Salsabila, Aisyah Salsabila, Salsabila Sari, Indah Permata Sembiring, Khairul Rasyid Septiady, Teuku Baihaqi Shaik Hussain, Basrah Bee Binte SITI MIRHALINA Siti Mulyani Sitompul, Asma Dwi Nantika Sri Rezeki Arbaningsih Tania Mulia Utami Tegar Alamsyah Teuku Baihaqi Septiady USWATUL KHOIROT Utami, Tania Mulia Widya Yustika Yulhan, Oche Axena Yusmawati Yusran Yustika, Widya Zavira, Raihana Zulkarnain, Rizki Chairani