Bone Resorption in Ameloblastoma and Its Underlying Mechanism

Jackson Jackson (Postgraduate Program in Dentistry, Faculty of Dentistry, Universitas Trisakti)
Johni Halim (Postgraduate Program in Dentistry, Faculty of Dentistry, Universitas Trisakti)
Rezky Anggraeni (Postgraduate Program in Dentistry, Faculty of Dentistry, Universitas Trisakti)
Ferry Sandra (Department of Biochemistry and Molecular Biology, Faculty of Dentistry, Universitas Trisakti)

Indonesian Journal of Cancer Chemoprevention
Vol 12, No 1 (2021)

Ameloblastoma, a tumor located in the jaw, grows slowly but locally invasive. Ameloblastoma expands in the jaw based on a mechanism resorbing the surrounding bone. To date, the bone resorption mechanisms of ameloblastoma are associated with the expression of receptor activator of nuclear factor (NF)-κB (RANK) ligand (RANKL), matrix metalloproteinases (MMPs), and tumor necrosis factor (TNF)-α. RANKL plays an important role in generating osteoclastogenesis. MMPs degrade the extracellular matrix. TNF-α can induce the formation of osteoclast and modulate the MMPs. In this review the bone resorption mechanism of ameloblastoma as well its signaling pathway will be disclosed.Keywords: Ameloblastoma, RANKL, MMPs, TNF-α.