Indonesian Journal of Cancer Chemoprevention
Vol 12, No 1 (2021)

Bone Resorption in Ameloblastoma and Its Underlying Mechanism

Jackson, Jackson (Unknown)
Halim, Johni (Unknown)
Anggraeni, Rezky (Unknown)
Sandra, Ferry (Unknown)

Article Info

Publish Date
28 Feb 2021

Abstract

Ameloblastoma, a tumor located in the jaw, grows slowly but locally invasive. Ameloblastoma expands in the jaw based on a mechanism resorbing the surrounding bone. To date, the bone resorption mechanisms of ameloblastoma are associated with the expression of receptor activator of nuclear factor (NF)-κB (RANK) ligand (RANKL), matrix metalloproteinases (MMPs), and tumor necrosis factor (TNF)-α. RANKL plays an important role in generating osteoclastogenesis. MMPs degrade the extracellular matrix. TNF-α can induce the formation of osteoclast and modulate the MMPs. In this review the bone resorption mechanism of ameloblastoma as well its signaling pathway will be disclosed.Keywords: Ameloblastoma, RANKL, MMPs, TNF-α.

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Journal Info
Indonesian Journal of Cancer Chemoprevention
Website

Abbrev

ijcc

Publisher

Indonesian Society for Cancer Chemoprevention

Subject

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Description

Indonesian Journal of Cancer Chemoprevention (IJCC) is an open access, peer-reviewed, triannual journal devoted to publishing articles on Cancer Chemoprevention including Experimental and Clinical Pharmacology, especially concerning Anti-Oxidants, Anti-Aging, Anti-Inflammation, Anti-Angiogenesis, ...