Bioactive Secondary Metabolites from the Mangrove Endophytic Fungi Nigrospora oryzae

Antonius Rolling Basa Ola (Department of Chemistry, Faculty of Science and Engineering, Universitas Nusa Cendana, Jl. Adisucipto, Penfui-Kupang 85118, NTT, Indonesia)
Titus Lapailaka (Department of Chemistry, Faculty of Science and Engineering, Universitas Nusa Cendana, Jl. Adisucipto, Penfui-Kupang 85118, NTT, Indonesia)
Hermania Em Wogo (Department of Chemistry, Faculty of Science and Engineering, Universitas Nusa Cendana, Jl. Adisucipto, Penfui-Kupang 85118, NTT, Indonesia)
Julinda Bendalina Dengga Henuk (Agro Technology Department, Faculty of Agriculture, Universitas Nusa Cendana, Kupang, NTT, Indonesia)
Agnes Simamora (Agro Technology Department, Faculty of Agriculture, Universitas Nusa Cendana, Kupang, NTT, Indonesia)
Lince Mukkun (Agro Technology Department, Faculty of Agriculture, Universitas Nusa Cendana, Kupang, NTT, Indonesia)
Peter Proksch (Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany)
Chong Dat Pham (Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, 1881 East Road, Houston, TX-77054, USA)

Indonesian Journal of Chemistry
Vol 21, No 4 (2021)

Mangrove forest has a distinctive habitat adapting with marine and terrestrial environment. Chemical investigation of the extract from mangrove endophytic fungi Nigrospora oryzae had resulted in the isolation of sterigmatocystin (1) and pestalopyrone (2). The structure of sterigmatocystin (1) and pestalopyrone (2) were elucidated using mass, UV and NMR spectrometers together with the comparison with the literature data. The study also showed that sterigmatocystin displayed moderate cytotoxicity but it could be further developed as antiviral and antibacterial agent based on the SAR information reported from its analogue and derivatives.