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All Journal JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI INDONESIAN JOURNAL OF PHARMACY ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Agrica: Journal of Sustainable Dryland Agriculture Chemistry Notes
Antonius R.B. Ola
Jurusan Kimia, Fakultas Sains Dan Teknik, Universitas Nusa Cendana Jalan Adisucipto Penfui, Kupang, Nusa Tenggara Timur, 85001, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology

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ANALISIS SENYAWA ANTIBIOTIK DARI JAMUR SIMBION YANG TERDAPAT DALAM ASCIDIANS Didemnum molle DI SEKITAR PERAIRAN BUNAKEN-SULAWESI UTARA Bara, Robert A.; Kandou, Grace D.; Ola, Antonius R. B.; Posangi, Jimmy
JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI Vol 2, No 2 (2015)
Publisher : JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Endosymbiont can be interpreted as microbes that live in colonies in the internal tissues of other higher organisms without causing adverse effects directly on the its host. Endosymbiont organisms have a huge potential to be exploited as a new natural products that are useful in medicine, agriculture, and industry. This research is focused on the antibacterial potential. Ascidians Didemnum moll speciments were collected from Manado waters. The fungal isolates were purified followed by screening their antibacterial activity towards Staphylococcus aureus and Pseudomonas aeruginosa. In this study we isolated 3 fungal specimens Acremonium sp. (ADMB-1, 2 and 3). Three isolates showed potential antibacterial activity. Together with the fungal isolates, we also isolated Bacillus galacosidilyticus from the same host. This bacterial isolate also show antibacterial potency.
Molecular identification and anticancer activity of alkylphenol from cashew nut shell oil (Anacardium occidentale) grown In Timor Island Antonius R B Ola; Zullies Ikawati; Sismindari .; Ermelinda D Meye; Bibiana Dho Tawo
Indonesian Journal of Pharmacy Vol 19 No 3, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1717.444 KB) | DOI: 10.14499/indonesianjpharm0iss0pp137-144

Abstract

Isolation of anacardic acid and cardanol from cashew nut shell liquid and their cytotoxic activity to on ward HeLa cancer cell line has been done. The objective of this research is to isolate and identify anacardic acid and cardanol from CNSL along with their cytototoxic activity towards HeLa cancer cell lines. Anacardic acid was isolated as calcium anacardate. Hydrolisis of this acid with acid chloride yields anacardic acid . Liquor ammonia was added to the acid-free CNSL and extracted with hexane/ethyl acetate (98:2) to isolate cardanol and with ethyl acetate/hexane (80:20) to separate cardol. Cardanol was obtained as the main chemical component of CNSL derived from Kupang district. Anacardic acid and cardanol was analyzed using IR and GC-MS. Anticancer activity of chemical components of CNSL against HeLa cancer cell lines were studied using MTT. Cytotoxic activity test showed that CNSL, anacardic acid and cardanol can be developed as anticancer agent.Key words : CNSL, anacardic acid, cardanol, anticancer.
C-15 ACETOGENINS FROM THE MARINE ALGA Chondria Antonius R.B. Ola; Bruce F. Bowden
Indonesian Journal of Chemistry Vol 8, No 3 (2008)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1460.121 KB) | DOI: 10.22146/ijc.21603

Abstract

(-) Z-Pinnatifidenyne, a novel C-15 acetogenin has been isolated along with the known compound (+)-3Z,6R,7R-obtusenyne and (+) (3Z)-laurenyne from the Australian red alga Chondria armata. The structures of the compounds were elucidated based on spectral data analysis including 2D NMR spectroscopic experiment.
Bioactive Secondary Metabolites from the Mangrove Endophytic Fungi Nigrospora oryzae Antonius Rolling Basa Ola; Titus Lapailaka; Hermania Em Wogo; Julinda Bendalina Dengga Henuk; Agnes Simamora; Lince Mukkun; Peter Proksch; Chong Dat Pham
Indonesian Journal of Chemistry Vol 21, No 4 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.63129

Abstract

Mangrove forest has a distinctive habitat adapting with marine and terrestrial environment. Chemical investigation of the extract from mangrove endophytic fungi Nigrospora oryzae had resulted in the isolation of sterigmatocystin (1) and pestalopyrone (2). The structure of sterigmatocystin (1) and pestalopyrone (2) were elucidated using mass, UV and NMR spectrometers together with the comparison with the literature data. The study also showed that sterigmatocystin displayed moderate cytotoxicity but it could be further developed as antiviral and antibacterial agent based on the SAR information reported from its analogue and derivatives.
Profil Kandungan Kimia, Fenolik Total, dan Aktivitas Antioksidan Ekstrak Etanol Tumbuhan Litsea firma (Blume) Hook F Yana Aisya Putri; Rini Muharini; Ira Lestari; Masriani Masriani; Rudiyansyah Rudiyansyah; Antonius R.B. Ola
ALCHEMY Jurnal Penelitian Kimia Vol 20, No 1 (2024): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.20.1.74158.38-48

Abstract

Litsea firma (Blume) Hook f atau medang piawas merupakan salah satu tumbuhan tingkat tinggi yang dijumpai di Kabupaten Melawi, Kalimantan Barat, Indonesia. Masyarakat setempat memanfaatkannya sebagai obat tradisional untuk menyembuhkan alergi kulit dan menghilangkan bau badan. Penelitian ini bertujuan untuk menentukan profil kandungan kimia, fenolik total, dan aktivitas antioksidan ekstrak akar, batang, dan daun Litsea firma. Analisis fitokimia dan kromatogram reversed phase-high performance liquid chromatography (RP-HPLC) menunjukkan bahwa komponen utama pada setiap ekstrak etanol adalah golongan senyawa fenolik dan cenderung bersifat polar. Kadar fenolik total ditentukan menggunakan metoda Folin-Ciocalteu. Hasil menunjukkan bahwa kadar fenolik total tertinggi adalah ekstrak etanol batang sebesar 90,85 mg GAE/g ekstrak, diikuti ekstrak akar (70,29 mg GAE/g ekstrak) dan daun (51,52 mg GAE/g ekstrak). Penentuan aktivitas antioksidan dilakukan menggunakan 2,2-Diphenyl-1-picrylhydrazyl (DPPH) dengan asam askorbat sebagai kontrol positif. Ekstrak akar, batang, dan daun menunjukkan aktivitas antioksidan moderat dengan IC50 secara berurutan sebesar 134,45 ppm, 112,21 ppm, dan 157,94 ppm,. Dengan demikian, ekstrak batang merupakan sumber senyawa fenolik dan antioksidan yang lebih baik dibandingkan bagian lain tumbuhan L. firma (Blume) Hook f. Characterization of Chemical Composition, Phenolic Content, and Antioxidant Activity of Ethanol Extract from Litsea firma (Blume) Hook F Plants. Litsea firma (Blume) Hook f is one of the higher plants distributed widely in Sungai Pinang Village, Melawi Regency, West Kalimantan, Indonesia. Local people use some parts of the plant as a traditional medicine to cure skin allergies and eliminate body odor. This study aimed to analyze the chemistry profile, measure the phenolic content, and determine the antioxidant activity of Litsea firma roots, stems, and leaf extracts. Phytochemical and reversed phase-high performance liquid chromatography (RV-HPLC) chromatogram analysis on each ethanolic extract showed that each extract possessed a similar phytochemical profile of polar phenolic compounds as major compounds. The Folin-Ciocalteu method was used to determine the total phenolic content using gallic acid as a standard. The results showed that the total phenolic content in the roots, stems, and leaves extract was 70.29, 90.85, and 51.52 mg GAE/g extract, respectively., where phenolic content in the stems was the highest. Antioxidant activity was evaluated using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) with ascorbic acid as a reference standard. The extracts of the roots, stems, and leaves showed moderate antioxidant activity with IC50 values of 134.45 ppm, 112.21 ppm, and 157.94 ppm, respectively. Thus, stem extract Litsea firma Blume has a better antioxidant and phenolic resource from this species.
IDENTIFIKASI PENYAKIT PADA TANAMAN PADI DI KELURAHAN OESAO, KABUPATEN KUPANG, NUSA TENGGARA TIMUR Simamora, Agnes V; Hahuly, Mayavira V; Ishaq, Lily F; Nenotek, Petronella S; Ola, Antonius R B; Hosang, Evert Y; Fitriadi, Bayu Refindra
AGRICA Vol. 18 No. 1 (2025): June
Publisher : Agriculture Faculty of Flores University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/agr.v18i1.5337

Abstract

Rice is one of the primary food crops that plays a vital role in improving the welfare of Indonesian society. However, crop failures often occur, one of which is caused by pathogen attacks. This study aimed to identify the types of pathogens affecting rice plants in Oesao Village, Kupang Timur District, Kupang Regency. The research was conducted from February to April 2024. Samples of diseased rice plants were collected from Oesao Village, while the isolation and identification processes were carried out at the Microbiology Laboratory, Faculty of Agriculture, Univesitas Nusa Cendana. The study utilized the diagonal sampling method by selecting five points within a paddy field and observing plants showing disease symptoms. Diseased plant parts were examined, photographed, sampled, and brought to the laboratory for pathogen isolation and identification. The results identified five types of pathogens infecting rice plants: Alternaria padwickii (causing circular leaf spots), Curvularia sp. (causing brown leaf spots), Drechslera oryzae (causing leaf spots), Fusarium oxysporum (causing stem spots), and Fusarium sambucinum (causing root rot). Interviews with farmers revealed that these pathogens significantly contribute to the decline in rice production in Oesao. These findings are crucial for developing pathogen control strategies in rice cultivation to enhance yield and food security in Indonesia, particularly in Oesao and its surrounding areas.
Analisis Kandungan Metabolit Sekunder dan Uji aktivitas Antibakteri Jamur Endofit Batang Binahong (Anredera COrdifiolia Steenis) Ola, Antonius R B; Bria, Elisabeth Indriyani Paula; da Cunha, Theo
Chemistry Notes Vol 5 No 2 (2023): Chem Notes, 5(2), 2023
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cn.v1i2.1197

Abstract

The isolation of endophytic fungi (penicillium sp) from binahong stem had been undertaken with the objective to determine its content of secondary metabolites and its antibacterial activity. The content of secondary metabolites was analyzed with HPLC and its antibacterial activity was measured using paper disc diffusion method. The results showed that there were four compounds in the HPLC chromatogram detected at 235 nm. The antibacterial activity for methanol and ethyl acetate extracts were observed for its diameter of zone inhibition at 18.2 mm and 16.7 mm for S.aureus and 17.8 mm and 16.3 mm for E. Coli.
DETERMINATION OF TOTAL TANIN CONTENTS OF Terminalia Catappa, L. LEAF EXTRACT AND TEST OF ITS ABILITY AS A COMPLEXION AGENT OF Fe (III) Ola, Pius D.; Sandri, Mariana I.; Ola, Antonius R. B.; Kadang, Luther
Chemistry Notes Vol 2 No 2 (2020): Chem. Notes 2020, 2(2)
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cn.v2i2.3361

Abstract

A study of the essential oil content in basil (Ocimum sanctum) and red lemongrass (Cymbopogon nardus L. Rendle) originally grown in Flores island has been conducted. The purpose of this study was to identify the chemotype of the essential oils obtained over stahl distillation using GC-MS. The Ocimum mainly consisted of 55% eugenol following by minor trans-alfa-bergometena, patchulana, and linalool. Meanwhile, the chemotype of the red lemongrass (Cymbopogon nardus L. rendle) were citronellol (22%), citronella, cyclohexamethanol, and viridiflorol.
Bioaktivitas Metabolit Sekunder dari Genus Dipterocarpus Nalle, Halena A.; Lulan, Theodore Y. K.; de Rozari, Philiphi; Ola, Antonius R. B.
Chemistry Notes Vol 4 No (1) (2022): Chem. Notes 2022, 4 (1)
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cn.v3i2.6078

Abstract

Research has been conducted with the title "Literature Study of Secondary Metabolites and Bioactivity of Plants Genus Dipterocarpus". The method used is a descriptive method with the aim of being to find out the active compounds in the genus plant dipterocarpus and to know the ability of the bioactivity of genus plants dipterocarpus. Based on the results of the study, bioactivity of secondary metabolites from planst of the genus dipterocarpus namely antidiabetic, antiplasmodial, antibacterial, antioxidant, anticlasses, cytotoxic, anticholinesterase, antiproliferation, anti-inflammatory and antimicrobial. Very strong biosaltivity indicated by the ethyl acetate faction plant D. Intricatus Sagai Antioxidant IC50 Nialial is 0.075 μg / mL. While very weak bioacchables are shown extract methanol stem plant D. Costatus as cytotoxic with ic50 value 973 ± 14.57 μg / mL.
Karakteristik Pelumas Bekas Hasil Adsorpsi Menggunakan Arang Batang Kesambi (Schleichera oleosa) dan Zeolit Alam Ende Teraktivasi H3PO4 Cunha, Theodorus M. Da; Fone, Maria Y.B.; Tawa, Bibiana Dho; Ola, Antonius R. B.
Chemistry Notes Vol 4 No (1) (2022): Chem. Notes 2022, 4 (1)
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cn.v4i(1).7734

Abstract

Used lubricants contain contaminants from oxidation and thermal degradation, resulting in a decrease in the quality and performance of the lubricant. Therefore, the adsorption process is carried out using kesambi stem charcoal and natural zeolite Ende activated H3PO4 to remove contaminants and improve the quality of used lubricants. Determination of the density and kinematic viscosity of used lubricants mass variations of 0.5, 0.66, 1 and 2 grams for each adsorbent. The results obtained show that the value of the used lubricant density from the adsorption results is relatively the same, namely 0.83 g/cm3, while the kinematic viscosity is different for each variation of the mass and type of adsorbent. Kesambi stem active charcoal has an optimum mass of 0.66 grams with a kinematic viscosity value of 128.84 cSt, active natural zeolite at a mass of 0.5 grams of 113.59 cSt and continued use of active natural zeolite-active natural charcoal, namely at a mass of 2 grams of 106, 38 cSt. These results indicate that the variation in the mass of the adsorbent has no effect on the change in density value but shows a significant change in the increase in the value of the kinematic viscosity of the used lubricant from the adsorption. The best percentage of kinematic viscosity increase efficiency is using activated charocoal, which is 71.83%.
Co-Authors Agnes Simamora Bagung, Dionisius Yosama Bayu Refindra Fitriadi, Bayu Refindra Bibiana Dho Tawo Bria, Elisabeth Indriyani Paula Bruce F. Bowden Chong Dat Pham Cunha, Theodorus M. Da Da Cunha, Theo Dasul, Aprilia R. T. De Carvalho, Filomena Gizela Dodi Darmakusuma, Dodi Ermelinda D Meye Fone, Maria Y.B. Grace Debbie Kandou Hahuly, Mayavira V Hermania Em Wogo Hosang, Evert Y Ira Lestari Ishaq, Lily F Jimmy Posangi Julinda Bendalina Dengga Henuk Kadang, Luther Kusuma, Albert W. Lapailaka, Titus Ledoh, Sherlly M. F. Lince Mukkun Lulan, Theodore Y. K. Lulan, Theodore Y.K. Masriani Masriani Nalle, Halena A. Nenotek, Petronella S Nitbani, Febri O. Ola, Pius D. Peter Proksch Philiphi de Rozari Rini Muharini Robert A. Bara Rudiyansyah Rudiyansyah Sandri, Mariana I. Sismindari . sukur, sutra Tawa, Bibiana Dho Yana Aisya Putri Zullies Ikawati