Human Papilloma Virus: Biomolecular Aspect

Patiyus Agustiansyah (Department of Obstetric and Gynecology, Division Oncology of Gynecology, Faculty of Medicine, Universitas Sriwijaya / General Hospital Dr Moh. Hoesin, Palembang, Indonesia)
Rizal Sanif (Department of Obstetric and Gynecology, Division Oncology of Gynecology, Faculty of Medicine, Universitas Sriwijaya / General Hospital Dr Moh. Hoesin, Palembang, Indonesia)
Siti Nurmaini (Intelligent System Research Group, Universitas Sriwijaya, Palembang, Indonesia)
Irfannuddin (Department of Physiology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Legiran (Department of Anatomy, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)

Bioscientia Medicina : Journal of Biomedicine and Translational Research
Vol. 5 No. 8 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research

HPV is a sexually transmitted virus, and high-risk HPV DNA was found in 99.7%of cervical cancer specimens. Within 12 to 24 months of exposure to the virus,90% of HPV infections disappear or become inactive. However, infection with high-risk strains of HPV persist which then increases the risk of progression to cervicalcancer. The detection of precancerous lesions consists of various methods,including pap smear (conventional or liquid-base cytology / LBC), visualinspection of acetic acid (IVA), visual inspection of lugoliodine (VILI), and HPV DNAtest (genotyping / hybrid capture).