Study on swelling behaviour of HANP/PVA composites with adding PLGA for alveolar ridge preservation

Feni Istikharoh (Department of Dental Materials, Faculty of Dentistry, Universitas Brawijaya, Malang, Indonesia Department of Biomedical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia)
Hidayat Sujuti (Department of Biochemistry, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia)
Edi Mustamsir (Department of Orthopaedic, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia)
Astika Swastirani (Department of Oral Medicine, Faculty of Dentistry, Universitas Brawijaya, Malang, Indonesia)

Journal of Dentomaxillofacial Science
Vol. 6 No. 3 (2021): (Available online: 1 December 2021)

Objective: The aim of this study was to compare the swelling behaviour of Hand Polyvinyl Acetate/Polyvinyl alcohol (HANP/PVA) and HANP/PVA/Poly Lactic-co-Glycolic Acid (PLGA) composites.Material and Methods: This study was divided into 2 groups, HANP/PVA and HANP/PLGA/PVA composites which prepared by freeze drying methods. HANP 20% (w/w) was combined with PLGA 20% (w/w) and dissolved in PVA solution at 50oC. Swelling behaviour was obtained by measured initial weight (Wi) and the weight of composites after immersing in PBS pH 7.4; 37oC for 7 days (swollen weight (Ws)). Statistical analysis based on Independent T-test (p<0.05).Results: The Wi of HANP/PVA and HANP/PLGA/PVA composites are 467±4.73 and 292±9.52. The Ws of HANP/PVA and HANP/PLGA/PVA composites are 897±26.61 and 860±32.36. Furthermore, the water retention of HANP/PVA composite is 92.07% (p<0.05) and HANP/PLGA/PVA composite is 194.52% (p<0.05).Conclusion: The addition of PLGA enhance swelling behaviour of HANP/PVA composites. The strong interaction between HANP and PVA decrease the swelling re. HANP is inert in nature, but the combination of HANP/PLGA/PVA can be a good substitute for alveolar preservation.